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Drugs reference index «Adapalene»


Brand names: Differin

Why is Adapalene prescribed?

Differin is prescribed for the treatment of acne.

Most important fact about Adapalene

Differin makes your skin more sensitive to sunlight. While using this product, keep your exposure to the sun at a minimum, and protect yourself with sunscreen and clothing. Never apply Differin to sunburned skin.

How should you take Adapalene?

Differin should be applied once a day at bedtime. Wash the affected areas, then apply a thin layer of the gel. Avoid eyes, lips, mouth, and nostrils. If you are using a single-use pledget, remove it from the foil just before using, and discard it after applying the medication. Do not use if the seal is broken.

Use Differin exactly as prescribed. Applying excessive amounts or using the gel more than once a day will not produce better results and may cause severe redness, peeling, and discomfort.

  • If you miss a dose...Don't try to make it up. Simply return to your regular schedule on the following day.
  • Storage instructions...Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue using Differin.

Side effects are most likely to occur during the first 2 to 4 weeks and usually diminish with continued treatment. If side effects are severe, your doctor may advise you to reduce the frequency of use or discontinue the drug entirely. Side effects disappear when the drug is stopped.

  • Side effects may include...Acne flare-ups, burning, dryness, irritation, itching, redness, scaling, stinging, sunburn

Why should Adapalene not be prescribed?

Do not use Differin if you are sensitive to adapalene or any other components of the gel.

Special warnings about Adapalene

If you have an allergic reaction or severe irritation, stop using the medication and call your doctor.

Remember that Differin increases sensitivity to sunlight. Take measures to protect yourself from overexposure. Wind and cold weather may also be irritating.

Do not apply Differin to cuts, abrasions, eczema, or sunburned skin.

In the first few weeks of treatment, your acne may actually seem to get worse. This just means the medication is working on hidden acne sores. Continue using the product. It can take as much as 8 to 12 weeks before you start to see improvement in your condition.

Differin has not been tested for children under 12 years old.

Possible food and drug interactions when taking Adapalene

Avoid using Differin with any other product that can irritate the skin, such as medicated soaps and cleansers, soaps and cosmetics that have a strong drying effect, and products with high concentrations of alcohol, astringents, spices, and lime.

Special caution is necessary if you have used, or are currently using, any skin product containing sulfur, resorcinol, or salicylic acid. Do not use such a product with Differin. If you have used one of these products recently, do not begin Differin treatment until the effects of the other product have subsided.

Special information if you are pregnant or breastfeeding

The effects of Differin during pregnancy and breastfeeding have not been adequately studied. If you are pregnant or plan to become pregnant, notify your doctor immediately. It is not known whether Differin appears in breast milk. If you are nursing and need to use Differin, your doctor may advise you to discontinue breastfeeding while using the medication.

Recommended dosage for Adapalene

The usual dose is a thin film applied over the acne-affected area just before bedtime.


Any medication taken in excess can have serious consequences. Overuse of Differin can cause redness, peeling, and discomfort. If you suspect an overdose, check with your doctor immediately.

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