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Drugs reference index «Clofarabine»

Clofarabine

Generic Name: Clofarabine (kloe-FAR-a-been)Brand Name: Clolar

Clofarabine is used for:

Treating certain types of leukemia in children and adolescents who have had at least 2 previous treatment regimens of medicine.

Clofarabine is a form of antimetabolite chemotherapy. It works by blocking cancer cell growth, which results in death of the cancer cell.

Do NOT use Clofarabine if:

  • you are allergic to any ingredient in Clofarabine
  • you are taking medicines that may affect the kidney, such as aminoglycoside antibiotics (eg, gentamicin), amphotericin B, cyclosporine, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), tacrolimus, and vancomycin. Ask your doctor if you are unsure whether any of your medicines might affect your kidneys
  • you are taking medicines that may affect the liver, such as acetaminophen, certain medicines for HIV infection, isoniazid, ketoconazole, and methotrexate. Ask your doctor if you are unsure whether any of your medicines might affect your liver

Contact your doctor or health care provider right away if any of these apply to you.

Before using Clofarabine :

Some medical conditions may interact with Clofarabine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have high or low blood pressure, kidney problems, liver problems, or heart problems
  • if you have an infection, certain blood problems (eg, low white blood cell levels, low platelet levels), or bone marrow problems
  • if you have previously had a hematopoietic stem cell transplant (HSCT)

Some MEDICINES MAY INTERACT with Clofarabine . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Medicines that may affect your heart function or blood pressure because the side effects of Clofarabine such as low blood pressure or heart effects may be increased. Ask your doctor if you are unsure whether any of your medicines might affect your heart function or blood pressure
  • Medicines that affect your kidneys or liver because the risk of Clofarabine 's side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Clofarabine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clofarabine :

Use Clofarabine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Clofarabine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Clofarabine at home, a health care provider will teach you how to use it. Be sure you understand how to use Clofarabine . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Clofarabine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Do not administer any other medicines through the same intravenous line as Clofarabine .
  • If Clofarabine accidentally spills on your skin, wash it off immediately with soap and water.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Clofarabine , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Clofarabine .

Important safety information:

  • Clofarabine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Clofarabine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
  • Notify your doctor immediately if you experience symptoms of dehydration such as dry mouth; decreased urination; unusual thirst; weakness; unusual drowsiness or lethargy; muscle pain, cramps, or weakness; severe dizziness or fainting; or rapid heartbeat.
  • Clofarabine may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Clofarabine may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • Proper dental care is important while you are taking Clofarabine . Brush and floss your teeth and visit the dentist regularly.
  • Tell your doctor or dentist that you take Clofarabine before you receive any medical or dental care, emergency care, or surgery.
  • Women who may become pregnant must use an effective form of birth control while they take Clofarabine . If you have questions about effective birth control, talk with your doctor.
  • Men who use Clofarabine should always use a condom when having sex with a woman who may become pregnant. Do this for as long as you use Clofarabine .
  • Lab tests, including blood counts, blood pressure, lung function, liver function, kidney function, and blood uric acid levels, may be performed while you use Clofarabine . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Safety and effectiveness of Clofarabine have not been established in ADULTS.
  • PREGNANCY AND BREAST-FEEDING: Clofarabine has been shown to cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clofarabine while you are pregnant. Do not breast-feed while taking Clofarabine .

Possible side effects of Clofarabine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; constipation; cough; decreased weight; diarrhea; dizziness; drowsiness; dry or irritated skin; flushing; gum bleeding; headache; itching; joint or muscle pain or weakness; loss of appetite; minor pain, swelling, or redness at the injection site; nausea; stomach pain; swelling or soreness of the mouth; tiredness or weakness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blistering or severe swelling or pain at the injection site; blood in the urine; cloudy or dark urine; decreased urination; fainting; fast breathing; fast or irregular heartbeat; fever, chills, or sore throat; mental or mood changes; nosebleed; persistent cough; pneumonia; red, swollen, blistered, or peeling skin; severe dizziness or lightheadedness; severe or persistent tiredness or weakness; severe or persistent vomiting or diarrhea; shaking; shortness of breath; small red spots under the skin; swelling of arms or legs; tingling, pain, redness, or swelling of the palms of the hands or soles of the feet; unusual bleeding or easy bruising; unusual tiredness or weakness; unusually pale skin; white patches in the mouth; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include rash; vomiting.

Proper storage of Clofarabine :

Store undiluted vials of Clofarabine at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. After diluting, Clofarabine may be stored at room temperature and must be used within 24 hours. Keep Clofarabine out of the reach of children and away from pets.

General information:

  • If you have any questions about Clofarabine , please talk with your doctor, pharmacist, or other health care provider.
  • Clofarabine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Clofarabine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Clofarabine Professional Patient Advice (Wolters Kluwer)
  • clofarabine Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
  • Clolar Prescribing Information (FDA)
  • Clolar Consumer Overview

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