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Drugs reference index «Clopidogrel»

Clopidogrel

Generic Name: Clopidogrel (kloe-PID-oh-grel)Brand Name: Plavix

Clopidogrel is used for:

Reducing the risk of stroke or heart attack in patients who have already had a heart attack or stroke, have other circulatory problems due to narrowing and hardening of the arteries, or have certain other heart problems (eg, unstable angina). It also may be used for other conditions as determined by your doctor.

Clopidogrel is a platelet aggregation inhibitor. It works by slowing or stopping platelets from sticking to blood vessel walls or injured tissues.

Do NOT use Clopidogrel if:

  • you are allergic to any ingredient in Clopidogrel
  • you have an active bleeding disorder, such as a stomach ulcer or bleeding in the brain
  • you take certain azole antifungals (eg, fluconazole, ketoconazole, voriconazole), cimetidine, etravirine, felbamate, fluoxetine, fluvoxamine, certain proton pump inhibitors (eg, omeprazole, esomeprazole), or ticlopidine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Clopidogrel :

Some medical conditions may interact with Clopidogrel . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bone marrow disease, liver or kidney problems, or a history of ulcers
  • if you have had a recent injury or surgery, including dental surgery

Some MEDICINES MAY INTERACT with Clopidogrel . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Dabigatran, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), oral anticoagulants (eg, warfarin), or salicylates (eg, aspirin) because the risk of bleeding may be increased by Clopidogrel
  • Azole antifungals (eg, ketoconazole), cimetidine, etravirine, felbamate, fluoxetine, fluvoxamine, proton pump inhibitors (eg, omeprazole), or ticlopidine because they may decrease Clopidogrel 's effectiveness
  • Fluvastatin, phenytoin, tamoxifen, tolbutamide, or torsemide because the risk of their side effects may be increased by Clopidogrel

This may not be a complete list of all interactions that may occur. Ask your health care provider if Clopidogrel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clopidogrel :

Use Clopidogrel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Clopidogrel by mouth with or without food.
  • If you miss a dose of Clopidogrel , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Clopidogrel .

Important safety information:

  • Clopidogrel may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Clopidogrel with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Clopidogrel may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Tell your doctor or dentist that you take Clopidogrel before you receive any medical or dental care, emergency care, or surgery. You may need to stop Clopidogrel before you have certain types of surgery.
  • Clopidogrel should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clopidogrel while you are pregnant. It is not known if Clopidogrel is found in breast milk. Do not breast-feed while taking Clopidogrel .

Possible side effects of Clopidogrel :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Easy bruising; minor bleeding.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; bleeding in the eye; change in vision; change in the amount of urine produced; chest pain; dark or bloody urine; fever or sore throat; loss of appetite; pale skin; seizures; severe, persistent headache; speech problems; unexplained weight loss; unusual bruising or bleeding; unusual or severe bleeding (eg, excessive bleeding from cuts, increased menstrual bleeding, unexplained vaginal bleeding, unusual bleeding from the gums when brushing); unusual tiredness or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Clopidogrel :

Store Clopidogrel at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clopidogrel out of the reach of children and away from pets.

General information:

  • If you have any questions about Clopidogrel , please talk with your doctor, pharmacist, or other health care provider.
  • Clopidogrel is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Clopidogrel . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Clopidogrel Prescribing Information (FDA)
  • Clopidogrel Professional Patient Advice (Wolters Kluwer)
  • clopidogrel Advanced Consumer (Micromedex) - Includes Dosage Information
  • Plavix Prescribing Information (FDA)
  • Plavix Detailed Consumer Information (PDR)
  • Plavix Consumer Overview

See Also...

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