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Drugs reference index «Clorazepate»


Generic Name: Clorazepate (klor-AZE-eh-pate)Brand Name: Tranxene T-Tab

Clorazepate is used for:

Treating nervousness or anxiety, seizures, and alcohol withdrawal. It may also be used for other conditions as determined by your doctor.

Clorazepate is a benzodiazepine. It works by slowing down the movement of chemicals in the brain. This results in a reduction in nervous tension (anxiety) and causes little drowsiness.

Do NOT use Clorazepate if:

  • you are allergic to any ingredient in Clorazepate
  • you are taking sodium oxybate (GHB)
  • you have narrow-angle glaucoma or severe liver disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using Clorazepate :

Some medical conditions may interact with Clorazepate . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicines, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have glaucoma, liver problems, seizures, muscle problems, a blood disorder, lung problems, depression, thoughts of suicide, or psychosis
  • if you have a history of alcohol or substance abuse or dependence

Some MEDICINES MAY INTERACT with Clorazepate . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin) or rifampin because they may decrease Clorazepate 's effectiveness
  • Disulfiram, HIV protease inhibitors (eg, ritonavir), nefazodone, omeprazole, sodium oxybate (GHB), or valproic acid because side effects, such as confusion and increased drowsiness, may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Clorazepate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clorazepate :

Use Clorazepate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Clorazepate by mouth with or without food.
  • If you also take clozapine, do not take it within 2 hours before or after taking Clorazepate . These doses must be separated. Check with your doctor if you have questions.
  • Do not suddenly stop taking Clorazepate . You may have an increased risk of serious side effects.
  • If you miss a dose of Clorazepate and are using it regularly, take it as soon as possible. If you do not remember until later, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Clorazepate .

Important safety information:

  • Clorazepate may cause blurred vision, dizziness, drowsiness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Clorazepate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are using Clorazepate .
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Clorazepate ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • The risk of Clorazepate becoming habit-forming may be greater if you take Clorazepate in high doses or for a long time. Do NOT take more than the recommended dose or take for longer than prescribed without checking with your doctor.
  • Lab tests, including liver and kidney tests, may be performed while you use Clorazepate . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Clorazepate with caution in the ELDERLY; they may be more sensitive to its effects.
  • Clorazepate should be used with extreme caution in CHILDREN younger than 9 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Clorazepate has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clorazepate while you are pregnant. Clorazepate is found in breast milk. Do not breast-feed while taking Clorazepate .

When used for long periods of time or at high doses, Clorazepate may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Clorazepate stops working well. Do not take more than prescribed. Some people who use Clorazepate for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. Talk with your doctor if Clorazepate stops working well. Do not take more than prescribed. If you suddenly stop taking Clorazepate , you may experience WITHDRAWAL symptoms.

Possible side effects of Clorazepate :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; clumsiness; confusion; dizziness; drowsiness; dry mouth; headache; lightheadedness; nervousness; stomach upset; unsteadiness; unusual weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include clumsiness; confusion; deep sleep; drowsiness; impaired coordination; loss of consciousness; slow reflexes.

Proper storage of Clorazepate :

Store Clorazepate between 59 and 77 degrees F (15 and 25 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clorazepate out of the reach of children and away from pets.

General information:

  • If you have any questions about Clorazepate , please talk with your doctor, pharmacist, or other health care provider.
  • Clorazepate is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Clorazepate . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Clorazepate Prescribing Information (FDA)
  • clorazepate Concise Consumer Information (Cerner Multum)
  • clorazepate Advanced Consumer (Micromedex) - Includes Dosage Information

See Also...

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