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Drugs reference index «Clotrimazole»



Brand names: Gyne-Lotrimin, Lotrimin, Mycelex, Mycelex-7

Why is Clotrimazole prescribed?

Clotrimazole, the active ingredient in these medications, is used to treat fungal infections. In preparations for the skin, it is effective against ringworm, athlete's foot, and jock itch. In vaginal creams and tablets, it is used against vaginal yeast infections. In lozenge form, it is prescribed to treat oral yeast infections and to prevent them in people with weak immune systems.

Most important fact about Clotrimazole

Keep using this medicine for the full time of treatment, even if the infection seems to have disappeared. If you stop too soon, the infection could return. You should continue using the vaginal forms of this medicine even during your menstrual period.

How should you take Clotrimazole?

Keep all forms of this medicine away from your eyes.

Before applying the skin preparations, be sure to wash your hands. Massage Gyne-Lotrimin gently into the affected area and the surrounding skin.

If you are taking Mycelex troches, place the lozenge in your mouth and let it dissolve slowly for 15 to 30 minutes. Do not chew the lozenge or swallow it whole.

If you are using a vaginal cream or tablet, use the following administration technique:1. Load the applicator to the fill line with cream, or unwrap a tablet, wet it with warm water, and place it in the applicator as shown in the instructions you receive with the product.2. Lie on your back with your knees drawn up.3. Gently insert the applicator high into the vagina and push the plunger.4. Withdraw the applicator and discard it if disposable, or wash with soap and water.

To keep the vaginal medication from getting on your clothing, wear a sanitary napkin. Do not use a tampon because it will absorb the medicine. Wear underwear or pantyhose with a cotton crotch%mdash;avoid synthetic fabrics such as nylon or rayon. Do not douche unless your doctor tells you to do so.

To keep the vaginal medication from getting on your clothing, wear a sanitary napkin. Do not use a tampon because it will absorb the medicine. Wear underwear or pantyhose with a cotton crotch--avoid synthetic fabrics such as nylon or rayon. Do not douche unless your doctor tells you to do so.

--If you miss a dose...

Make up for it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule.

--Storage instructions...

Store at room temperature, away from heat, light, and moisture.

Clotrimazole side effects

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue using Clotrimazole.

  • Side effects may include:Blistering, burning, hives, irritated skin, itching, peeling, reddened skin, stinging, swelling due to fluid retention
  • Side effects of clotrimazole vaginal preparations may include:Abdominal/stomach cramps/pain, burning/irritation of penis of sexual partner, headache, pain during sexual intercourse, skin rash, hives, vaginal burning, vaginal irritation, vaginal itching, vaginal soreness during sexual intercourse

An unpleasant mouth sensation has been reported by some people taking Mycelex.

Why should Clotrimazole not be prescribed?

You should not be using Gyne-Lotrimin if you have had an allergic reaction to any of its ingredients.

Special warnings about Clotrimazole

Contact your doctor if you experience increased skin irritations (such as redness, itching, burning, blistering, swelling, or oozing).

Check with your doctor before using Gyne-Lotrimin on a child.

In general, if your symptoms have not improved within 2 to 4 weeks of treatment, notify your doctor.

Clotrimazole vaginal preparations should not be used if you have abdominal pain, fever, or a foul-smelling vaginal discharge. Contact your doctor immediately.

While using the vaginal preparations, either avoid sexual intercourse or make sure your partner uses a condom. This will prevent reinfection. Oils used in some vaginal preparations can weaken latex condoms or diaphragms. To find out whether you can use your medication with latex products, check with your pharmacist.

Possible food and drug interactions when taking Clotrimazole

None have been reported.

Special information if you are pregnant or breastfeeding

The use of clotrimazole during the first trimester of pregnancy has not been adequately studied. It should be used during the first trimester only if clearly needed. Do not use clotrimazole at any time during pregnancy without the advice and supervision of your doctor.

It is not known whether clotrimazole appears in breast milk. Nursing mothers should use Gyne-Lotrimin cautiously and only when clearly needed.

Recommended dosage for Clotrimazole


Adults and Children

Wash your hands before and after you use Lotrimin. Apply in the morning and evening. Use enough Lotrimin to massage into the affected area.

Symptoms usually improve during the first week of treatment with Lotrimin.



Fill the applicator with the cream and insert 1 applicatorful into the vagina every day, preferably at bedtime. Repeat this procedure for 7 consecutive days.



The recommended dosage is 1 troche slowly dissolved in the mouth 5 times daily for 14 consecutive days. For prevention, the recommended dose is 1 troche 3 times daily.


Although any medication used in excess can have serious consequences, an overdose of clotrimazole is unlikely. If you suspect an overdose, however, seek medical help immediately.

  • Clotrimazole Cream MedFacts Consumer Leaflet (Wolters Kluwer)
  • Clotrimazole Prescribing Information (FDA)
  • Clotrimazole Professional Patient Advice (Wolters Kluwer)
  • clotrimazole Concise Consumer Information (Cerner Multum)
  • clotrimazole Mucous membrane, oral Advanced Consumer (Micromedex) - Includes Dosage Information

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