Trade Names:Cruex- Cream 1%
Trade Names:Desenex- Cream 1%
Trade Names:Gyne-Lotrimin 3- Vaginal suppositories 200 mg- Vaginal cream 2%
Trade Names:Gyne-Lotrimin 3 Combination Pack- Vaginal suppositories 200 mg- Topical cream 1%
Trade Names:Gyne-Lotrimin 7- Vaginal cream 1%
Trade Names:Lotrimin AF- Cream 1%- Solution, topical 1%- Lotion 1%
Trade Names:Mycelex- Troches 10 mg
Trade Names:Mycelex-7- Vaginal cream 1%
Trade Names:Mycelex-7 Combination Pack- Vaginal suppositories 100 mg- Topical cream 1%Canesten Topical (Canada)Canesten Vaginal (Canada)Clotrimaderm (Canada)
Inhibits yeast growth by increasing cell membrane permeability in susceptible fungi.
After oral administration, the mean serum concentrations were about 4.98 and 3.23 ng/mL at 30 and 60 min, respectively. Minimally absorbed following topical and vaginal administration.
Treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), tinea corporis (ringworm), candidiasis, and tinea versicolor.Oral use (troche)
Treatment of oropharyngeal candidiasis; prophylaxis of oropharyngeal candidiasis in specific groups of immunocompromised patients.Vaginal use
Treatment of vulvovaginal candidiasis.
PO One 10 mg troche (lozenge) dissolved slowly in the mouth 5 times/day for 14 days.Prophylaxis
PO One 10 mg troche dissolved slowly in the mouth 3 times daily.Dermal Infections
Topical cream Apply thin layer to affected and surrounding areas twice daily in the morning and evening. Topical lotion Apply thin layer to affected areas twice daily.Vaginal InfectionsWomen and Girls Older Than 12 Yr of Age
Intravaginal Insert 1 applicatorful (5 g) of cream or one suppository at bedtime for 7 to 14 days (treatment for 14 days may yield higher cure rate).Gyne-Lotrimin Combination Pack
Insert suppository intravaginally at bedtime for 7 consecutive days. Apply topical cream to affected areas twice daily (morning and evening) for 7 consecutive days.Mycelex 7 Combination Pack
Insert suppository intravaginally at bedtime for 7 consecutive days. Apply topical cream to affected area twice daily (morning and evening) for 7 consecutive days.
Store cream and lotion in refrigerator (36° to 46°F) or at controlled room temperature (59° to 86°F). Keep tightly capped.Vaginal cream and tablets
Store vaginal cream and tablets at controlled room temperature (less than 86°F). Protect from freezing.Oral troche
Store troches at controlled room temperature (below 86°F). Protect from freezing.
None well documented.
None well documented.
Pruritus; erythema, stinging, blistering, peeling, edema, urticaria, burning, general skin irritation, rash (topical and vaginal products).
Unpleasant mouth sensations (troche).
Nausea, vomiting (troche).
Abnormal LFT results (troche).
Ensure that appropriate microbiological studies are completed before starting therapy and repeated to confirm diagnosis and rule out other pathogens before instituting another course of antimycotic therapy.Oral troche adverse reactions
Notify health care provider if patient using oral troche develops nausea, vomiting, abdominal cramps or discomfort, or unpleasant mouth sensations.Response to therapy
Monitor patient's response to therapy. Notify health care provider if symptoms do not improve or worsen.Skin sensitivity
Notify health care provider if skin inflammation, irritation, or sensitization are noted at cream, lotion, or solution application site(s).Transaminases
Ensure that transaminases are determined periodically during prolonged therapy with oral troches, especially in patient with pre-existing hepatic function impairment.
Category C (troches); Category B (topical and vaginal use).
Safety not established in children younger than 3 yr of age.Topical
Safety and efficacy not established in children younger than 2 yr of age.
May indicate underlying medical cause, including diabetes or HIV infection.
Do not use for these conditions.
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