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Drugs reference index «Adipex-P»


Generic name: Phentermine hydrochlorideBrand names: Ionamin, Adipex-P

Why is Adipex-P prescribed?

Adipex-P, an appetite suppressant, is prescribed for short-term use (a few weeks) as part of an overall weight reduction program that also includes dieting, exercise, and counseling. The drug is for use only by excessively overweight individuals who have a condition—such as diabetes, high blood pressure, or high cholesterol—that could lead to serious medical problems.

Most important fact about Adipex-P

Be sure to use Adipex-P only as directed. It will lose its effect after a few weeks, and should be discontinued when this happens. If you try to boost its effectiveness by increasing the dose, you will run the risk of serious side effects and dependence on the drug.

How should you take Adipex-P?

Take Adipex-P before breakfast or up to 2 hours after breakfast. Tablets can be broken in half, if necessary.

Take Ionamin before breakfast or 10 to 14 hours before you go to bed. Ionamin capsules should be swallowed whole.

  • If you miss a dose...Skip the missed dose completely; then take the next dose at the regularly scheduled time.
  • Storage instructions...Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Adipex-P.

  • Side effects may include:Changes in sex drive, constipation, diarrhea, dizziness, dry mouth, exaggerated feelings of depression or elation, headache, high blood pressure, hives, impotence, inability to fall or stay asleep, increased heart rate, overstimulation, restlessness, stomach or intestinal problems, throbbing heartbeat, tremors, unpleasant taste

Why should Adipex-P not be prescribed?

If you are sensitive to or have ever had an allergic reaction to phentermine hydrochloride or other drugs that stimulate the nervous system, you should not take Adipex-P. Make sure your doctor is aware of any drug reactions you have experienced.

Do not take Adipex-P if you have hardening of the arteries, symptoms of heart or blood vessel disease, an overactive thyroid gland, the eye condition known as glaucoma, or high blood pressure. Also avoid Adipex-P if you are agitated, have ever abused drugs, or have taken an MAO inhibitor, including antidepressant drugs such as phenelzine sulfate and tranylcypromine sulfate, within the last 14 days.

Special warnings about Adipex-P

This drug can cause a rare but potentially fatal condition called primary pulmonary hypertension. Call your doctor immediately if you develop such warning signs as chest pain, shortness of breath, fainting spells, or swollen ankles.

This drug may affect your ability to perform potentially hazardous activities. Therefore, you should be extremely careful if you have to drive a car or operate machinery.

You can become psychologically dependent on Adipex-P. Consult your doctor if you rely on Adipex-P to maintain a state of well-being.

If you stop taking Adipex-P suddenly after you have taken high doses for a long time, you may find you are extremely fatigued or depressed, or that you have trouble sleeping.

If you continually take too much of any appetite suppressant it can cause severe skin disorders, a pronounced inability to fall or stay asleep, irritability, hyperactivity, and personality changes.

Even if your blood pressure is only mildly high, be careful taking Adipex-P.

Possible food and drug interactions when taking Adipex-P

Remember that Adipex-P should never be combined with the weight-loss drug fenfluramine; very dangerous side effects could result. This drug may also react badly with alcohol. Avoid alcoholic beverages while you are taking it.

If Adipex-P is taken with certain other drugs, the effects of either can be increased, decreased, or altered. It is especially important that you check with your doctor before combining Adipex-P with the following:

Drugs that boost serotonin levels, such as the antidepressants fluoxetine hydrochloride, paroxetine hydrochloride, and sertralineDrugs classified as MAO inhibitors, including the antidepressants phenelzine sulfate and tranylcypromine sulfateDiabetes medications such as insulin and glyburideHigh blood pressure medications such as guanethidine

Special information if you are pregnant or breastfeeding

The effects of Adipex-P during pregnancy have not been adequately studied. If you are pregnant, plan to become pregnant, or are breastfeeding, notify your doctor immediately.

Recommended dosage for Adipex-P



The usual dose is 1 capsule or tablet a day, taken before breakfast or up to 2 hours after breakfast. Some people need only half a tablet each day. Others may find it more effective to take half a tablet twice daily.


The usual dose is 1 capsule a day, taken before breakfast or 10 to 14 hours before bedtime.


This drug is not recommended for use in children under 16 years of age.


Any medication taken in excess can have serious consequences. An overdose of Adipex-P can be fatal. If you suspect an overdose, seek emergency medical treatment immediately.

  • Symptoms of Adipex-P overdose may include:Abdominal cramps, aggressiveness, confusion, diarrhea, exaggerated reflexes, hallucinations, high or low blood pressure, irregular heartbeat, nausea, panic states, rapid breathing, restlessness, tremors, vomiting

Fatigue and depression may follow the stimulant effects of Adipex-P.

In cases of fatal poisoning, convulsions and coma usually precede death.

  • Adipex-P Prescribing Information (FDA)
  • Adipex-P MedFacts Consumer Leaflet (Wolters Kluwer)
  • Adipex-P Concise Consumer Information (Cerner Multum)
  • Phentermine Prescribing Information (FDA)
  • Ionamin Prescribing Information (FDA)
  • Ionamin MedFacts Consumer Leaflet (Wolters Kluwer)

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