Generic Name: codeine and promethazine (KOE deen and proe METH a zeen)Brand Names: Codeine Phosphate-Promethazine HCl, Promethazine HCl and Codeine Phosphate, Promethazine with Codeine
Codeine is a narcotic. It is a pain reliever and a cough suppressant.
Promethazine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.
The combination of codeine and promethazine is used to treat cold or allergy symptoms such as runny nose, sneezing, and cough.
Codeine and promethazine may also be used for other purposes not listed in this medication guide.What is the most important information I should know about Codeine Phosphate-Promethazine HCl (codeine and promethazine)?
Tell your doctor about all of your medical conditions before you start taking this medication.
You should not use this medication if you are allergic to codeine or promethazine, or if you have asthma or other lung disease.Do not give this medication to a child younger than 6 years old. Codeine may be habit-forming and should be used only by the person it was prescribed for. Codeine and promethazine should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Codeine and promethazine should not be given to a child without the advice of a doctor. There are many other medicines that can cause interact with promethazine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.What should I discuss with my doctor before taking Codeine Phosphate-Promethazine HCl (codeine and promethazine)?You should not use this medication if you are allergic to codeine or promethazine, or if you have high blood pressure, a blood vessel disorder, or asthma. Do not give this medication to a child younger than 6 years old.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take this medication:
epilepsy or other seizure disorder;
asthma, COPD, sleep apnea, or other breathing disorders;
a stomach ulcer or digestive obstruction;
a weak immune system;
enlarged prostate, urination problems;
high or low blood pressure or heart disease;
gallbladder disease; or
a head injury or brain tumor.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
Contact your doctor if your symptoms do not improve within a few days of using codeine and promethazine.Store this medication at room temperature away from moisture, heat, and light. Keep track of how much of this medicine has been used. Codeine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Overdose symptoms include dizziness, extreme drowsiness, dry mouth, nausea, vomiting, cold and clammy skin, weak pulse, shallow breathing, fainting, seizure (convulsions), or breathing that stops.What should I avoid while taking Codeine Phosphate-Promethazine HCl (codeine and promethazine)?This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol, which can increase some of the side effects of codeine and promethazine. Tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, other pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by codeine and promethazine. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medication can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
restless muscle movements in your eyes, tongue, jaw, or neck, tremor (uncontrolled shaking);
shallow breathing, slow heartbeat;
feeling like you might pass out;
jaundice (yellowing of the skin or eyes);
confusion, agitation, hallucinations, unusual thoughts or behavior;
urinating less than usual or not at all; or
fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing.
Less serious side effects may include:
dizziness, drowsiness, sleepiness;
feeling restless, nervous, or anxious;
blurred vision, ringing in your ears;
constipation, mild nausea or vomiting;
warmth, redness, or tingly feeling under your skin;
sleep problems (insomnia);
dry mouth; or
mild skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.What other drugs will affect Codeine Phosphate-Promethazine HCl (codeine and promethazine)?
Many drugs can interact with codeine and promethazine. Below is just a partial list. Tell your doctor if you are using:
sedatives or anxiety medicines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion);
antidepressants such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or paroxetine (Paxil);
narcotic pain medicines such as meperidine (Demerol), morphine (MS Contin, MSIR), propoxyphene (Darvon, Darvocet), hydrocodone (Lortab, Vicodin), oxycodone (Percocet, Percodan), fentanyl (Duragesic), codeine (Fiorinal, Fioricet, Tylenol #3);
phenobarbital (Luminal), amobarbital (Amytal) or secobarbital (Seconal);
an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam); or
atropine (Donnatal, and others), belladonna, clidinium (Quarzan), dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), methscopolamine (Pamine), and scopolamine (Transderm-Scop).
This list is not complete and there may be other drugs that can interact with codeine and promethazine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.