Generic name: Lamivudine, ZidovudineBrand names: Combivir
Combivir is used to fight the human immunodeficiency virus (HIV) that causes AIDS. It is a combination product containing the two AIDS drugs, lamivudine and zidovudine. It is intended for use with additional AIDS drugs.
HIV does its damage by slowly destroying the immune system, eventually leaving the body defenseless against infections. The drugs in Combivir interfere with the virus's ability to reproduce, thus staving off the decline of the immune system and preserving better health.
Combivir is not a cure for HIV infection or AIDS. It does not completely eliminate HIV from the body or totally restore the immune system. There is still a danger of serious infections, so you should be sure to see your doctor regularly for monitoring and tests.
It's important to keep adequate levels of Combivir in your bloodstream at all times, so you need to take it regularly, exactly as prescribed, even when you're feeling better. Doses can be taken with or without food.
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Combivir.
You should not take Combivir if either component, lamivudine or zidovudine, has ever given you an allergic reaction.
Remember that Combivir does not totally eliminate HIV from the body. The infection can still be passed on to others through sexual contact or blood contamination.
Combivir can upset the body's acid balance. It can also cause low blood cell counts (anemia), which can adversely affect your health. It should be used with extreme caution by anyone with an existing shortage of blood cells or a disease of the bone marrow (where blood cells are produced). It is very important to have your blood tested regularly, especially if you have an advanced case of HIV.
Combivir is known to occasionally cause serious liver problems.
If you have the chronic liver disease hepatitis B, the virus that causes it may become resistant to the lamivudine component of Combivir. Your hepatitis may get worse when Combivir treatment is stopped.
Combivir can cause muscle pain and inflammation. Report these symptoms to your doctor.
If you weigh less than 110 pounds, you should not take Combivir. The lamivudine component of Combivir is not recommended in people with low body weight.
Because Combivir contains fixed doses of lamivudine and zidovudine, it cannot be used by people who might require a decrease or adjustment in the dosage of either drug, such as children and those with poor kidney or liver function.
Inflammation of the pancreas (pancreatitis) can be caused by the lamivudine component of Combivir. If any signs of a pancreas problem develop such as severe abdominal pain that goes on for days, accompanied by nausea and vomiting, stop taking Combivir and call your doctor immediately.
Another side effect seen in some people receiving drugs for HIV is a redistribution of body fat, leading to extra fat around the middle, a "buffalo hump" on the back, and wasting in the arms, legs, and face. Researchers don't know whether this represents a long-term health problem or not.
If Combivir is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Combivir with the following:Chemotherapy drugsDoxorubicinGanciclovirInterferonRibavirinStavudineTrimethoprim/SulfamethoxazoleZalcitabine
The effects of Combivir during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, notify your doctor immediately.
Since HIV infection can be passed to your baby through breast milk, you should not breastfeed your infant.
For adults and adolescents 12 and over, the recommended dose is one tablet (containing 150 milligrams of lamivudine and 300 milligrams of zidovudine) twice a day.
Combivir should not be taken by children under 12 years of age.
The symptoms of Combivir overdose are unknown at this time. However, any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.