Generic Name: entacapone (en TAK a pone)Brand Names: Comtan
When used with carbidopa and levodopa (Atamet, Parcopa, Sinemet), entacapone increases levels of levodopa in the body.
Entacapone is used together with carbidopa and levodopa to treat "wearing-off" symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control.
Entacapone may also be used for other purposes not listed in this medication guide.
You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medication. Talk with your doctor if you believe you have any intense or unusual urges while taking entacapone.Avoid drinking alcohol, which can increase some of the side effects of entacapone. Cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by entacapone. Tell your doctor if you regularly use any of these other medicines.
Entacapone may cause hallucinations (the sensation of hearing or seeing something that is not there), most commonly among elderly people. Call your doctor if you experience hallucinations.Do not stop using entacapone without first talking to your doctor. You may need to use less and less before you stop the medication completely.
Some people taking medicines for Parkinson's disease have developed skin cancer (melanoma). However, people with Parkinson's disease may have a higher risk than most people for developing melanoma. Talk to your doctor about your specific risk and what skin symptoms to watch for. You may need to have regular skin exams.What should I discuss with my healthcare provider before taking Comtan (entacapone)?You should not use this medication if you are allergic to entacapone, or if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.
If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before you take this medication, tell your doctor if you are allergic to any drugs, or if you have:
low blood pressure; or
You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking entacapone. It is not known whether the medicine actually causes this effect. Talk with your doctor if you believe you have any intense or unusual urges while taking entacapone.FDA pregnancy category C. It is not known whether entacapone is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether entacapone passes into breast milk or if it could harm a nursing baby. Do not take entacapone without telling your doctor if you are breast-feeding a baby. Entacapone may cause hallucinations (the sensation of hearing or seeing something that is not there), most commonly among elderly people. Call your doctor if you experience hallucinations.
Some people taking medicines for Parkinson's disease have developed skin cancer (melanoma). However, people with Parkinson's disease may have a higher risk than most people for developing melanoma. Talk to your doctor about your specific risk and what skin symptoms to watch for. You may need to have regular skin exams.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Entacapone must be taken together with carbidopa and levodopa. Entacapone used alone will not treat symptoms of Parkinson's disease.Entacapone can be taken with or without food. Taking the medicine with food may help prevent nausea, which is a common side effect of entacapone. Do not stop using entacapone without first talking to your doctor. You may need to use less and less before you stop the medication completely. Store entacapone at room temperature away from moisture and heat.
See also: Comtan dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include weakness, loss of coordination, trouble breathing, or seizure (convulsions).
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
feeling like you might pass out;
fever, stiff muscles, confusion, and sweating (especially when you first start taking entacapone);
tremors (uncontrolled shaking);
tight feeling in your chest, trouble breathing;
severe or ongoing diarrhea; or
muscle pain, tenderness, or weakness with fever or flu symptoms and dark colored urine.
Less serious side effects may include:
mild nausea, vomiting, stomach pain, or loss of appetite;
diarrhea or constipation;
dry mouth, sweating;
unusual skin changes;
dizziness, drowsiness; or
agitation or anxiety.
You may notice that your urine appears orange or brown in color, such as red, brown, or black. This is not a harmful side effect.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking entacapone, tell your doctor if you are using any of the following drugs:
cholestyramine (Prevalite, Questran);
epinephrine (Epi-Pen, and others);
isoetharine (Bronkosol, Bronkometer);
isoproterenol (Isuprel, Medihaler-Iso);
probenecid (Benemid); or
an antibiotic such as ampicillin, chloramphenicol, erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, and others), or rifampin (Rifadin, Rifater, Rifamate).
This list is not complete and there may be other drugs that can interact with entacapone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.