Generic Name: bendroflumethiazide and nadolol (BEN droe floo meth EYE a zide and NAD oh lol)Brand Names: Corzide 40/5, Corzide 80/5
Bendroflumethiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Nadolol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).
The combination of bendroflumethiazide and nadolol is used to treat high blood pressure (hypertension).
Bendroflumethiazide and nadolol may also be used for other purposes not listed in this medication guide.What is the most important information I should know about Corzide 40/5 (bendroflumethiazide and nadolol)?You should not use this medication if you have asthma, severe or uncontrolled heart failure, a serious heart condition such as "sick sinus syndrome" or "AV block," or if you are unable to urinate.
Before using this medication, tell your doctor if you have congestive heart failure, kidney or liver disease, cirrhosis, bronchospastic lung disease, a thyroid disorder, gout, lupus, diabetes, or if you are allergic to sulfa drugs.
If you are diabetic, check your blood sugar carefully. Using nadolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking bendroflumethiazide and nadolol. Talk with your doctor before changing any doses.Avoid drinking alcohol, which can lower your blood pressure and may add to the side effects of bendroflumethiazide and nadolol.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.Keep using this medication even if you feel fine. High blood pressure often has no symptoms.
There are many other medicines that can interact with bendroflumethiazide and nadolol. Tell your doctor about all the prescription and over-the-counter medications you use.What should I discuss with my doctor before taking Corzide 40/5 (bendroflumethiazide and nadolol)?You should not use this medication if you are allergic to bendroflumethiazide or nadolol, or if you have:
severe or uncontrolled heart failure;
a serious heart condition such as "sick sinus syndrome" or "AV block" (2nd or 3rd degree); or
If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before using bendroflumethiazide and nadolol, tell your doctor if you have:
congestive heart failure;
bronchospastic lung disease;
a thyroid disorder;
if you are allergic to sulfa drugs.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
You may take this medicine with or without food.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.Do not stop using bendroflumethiazide and nadolol suddenly, or you could have a serious or life-threatening heart problem. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.
To be sure this medication is not causing harmful effects, your blood pressure will need to be checked on a regular basis, and you may need blood tests. Do not miss any scheduled appointments.
Your blood and urine may both be tested if you have been vomiting or are dehydrated.
If you are diabetic, check your blood sugar carefully. Using nadolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking bendroflumethiazide and nadolol. Talk with your doctor before changing any doses.
This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using bendroflumethiazide and nadolol.If you need to have any type of surgery, tell the surgeon ahead of time that you are using bendroflumethiazide and nadolol. You may need to stop using the medicine for a short time.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.Store this medication in a tightly closed container at room temperature, away from heat and moisture.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
swelling, rapid weight gain, feeling short of breath, even with mild exertion;
fast, slow, or uneven heartbeat;
easy bruising or bleeding;
numbness or tingly feeling in your hands or feet;
feeling weak, drowsy, restless, or light-headed;
nausea, vomiting, dry mouth, extreme thirst, headache, confusion, hallucinations, seizure (convulsions);
increased urination, leg discomfort, muscle pain or weakness or limp feeling;
urinating less than usual or not at all;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
diarrhea, constipation, upset stomach;
dizziness, spinning sensation;
depressed mood; or
ringing in your ears.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Many drugs can interact with bendroflumethiazide and nadolol. Below is just a partial list. Tell your doctor if you are using:
amphotericin B (AmBisome, Abelcet, Fungizone);
a blood thinner such as warfarin (Coumadin);
a calcium supplement;
colestipol (Colestid) or cholestyramine (Prevalite, Questran);
digoxin (digitalis, Lanoxin);
gout medications such as probenecid (Benemid) or sulfinpyrazone (Anturane);
insulin or diabetes medicine you take by mouth;
lithium (Eskalith, Lithobid);
an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);
steroids (corticotropin, prednisone and others);
other heart or blood pressure medications (especially reserpine); or
NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), etodolac (Lodine), indomethacin, naproxen (Aleve, Naprosyn), and others.
This list is not complete and there may be other drugs that can interact with bendroflumethiazide and nadolol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.