Generic Name: dorzolamide and timolol ophthalmic (dor ZOLE a mide and TYE moe lole)Brand Names: Cosopt
Dorzolamide ophthalmic reduces the amount of fluid in the eye, which decreases pressure inside the eye. Timolol ophthalmic is a beta-blocker that also reduces pressure inside the eye.
The combination of dorzolamide and timolol ophthalmic is used to treat certain types of glaucoma and other causes of high pressure inside the eye.
Dorzolamide and timolol ophthalmic may also be used for other purposes not listed in this medication guide.What is the most important information I should know about dorzolamide and timolol ophthalmic?Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.
Do not use any other eye medication unless your doctor has prescribed it for you. If you use another eye medication, use it at least 10 minutes before or after using dorzolamide and timolol ophthalmic. Do not use the medications at the same time.Dorzolamide and timolol ophthalmic can cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.What should I discuss with my healthcare provider before using dorzolamide and timolol ophthalmic?You should not use this medication if you are allergic to dorzolamide (Trusopt) or timolol (Blocadren, Betimol, Istalol, Timoptic), or if you have:
asthma or chronic obstructive pulmonary disease (COPD);
certain heart conditions, especially "AV block";
a heart rhythm disorder; or
severe or uncontrolled congestive heart failure.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use dorzolamide and timolol ophthalmic:
breathing problems such as bronchitis or emphysema;
a history of heart disease or congestive heart failure;
a muscle disorder such as myasthenia gravis;
liver disease; or
a thyroid disorder.
Use dorzolamide and timolol ophthalmic exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.Wash your hands before using the eye drops.
To apply the eye drops:
Tilt your head back slightly and pull down on the lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper. Squeeze out a drop and close your eye. Gently press your finger to the inside corner of the eye (near the nose) for about 1 minute to keep the liquid from draining into your tear duct.
If you use the drops in both eyes, repeat the steps above in your other eye. Also wait at least 10 minutes before using any other eye drops that your doctor has prescribed.
If you need to have any type of surgery, especially eye surgery, tell the surgeon ahead of time that you are using dorzolamide and timolol ophthalmic. You may need to stop using the medicine for a short time.Store this medication at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and use the medicine at the next regularly scheduled time. Do not use extra medicine to make up the missed dose.
Overdose symptoms may include feeling dizzy, light-headed, or short of breath, headache, slow heart beat, difficulty breathing, chest pain, or fainting.
Do not use any other eye medication unless your doctor has prescribed it for you. If you use another eye medication, use it at least 10 minutes before or after using dorzolamide and timolol ophthalmic. Do not use the medications at the same time.
swelling or redness of your eyelids;
eye redness, discomfort, or sensitivity to light;
drainage, crusting, or oozing of your eyes or eyelids;
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
wheezing, gasping, or other breathing problems;
swelling, rapid weight gain; or
feeling short of breath, even with mild exertion.
Less serious side effects may include:
blurred vision, double vision, drooping eyelid;
burning or stinging in your eye;
unusual taste in your mouth;
stomach or back pain;
nausea, upset stomach;
sore throat, stuffy nose; or
headache, or feeling light-headed.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before using dorzolamide and timolol ophthalmic, tell your doctor if you are using any of the following drugs:
quinidine (Cardioquin, Quinidex, Quinaglute);
digitalis (digoxin, Lanoxin, Lanoxicaps);
acetazolamide (Diamox) or methazolamide (Neptazane);
a beta-blocker such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others;
a calcium channel blocker such as diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nifedipine (Procardia, Adalat), verapamil (Calan, Covera, Isoptin, Verelan), and others; or
an antidepressant such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), or sertraline (Zoloft).
This list is not complete and there may be other drugs that can interact with dorzolamide and timolol ophthalmic. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.