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Drugs reference index «Cosopt»

Cosopt
Cosopt
Cosopt


Cosopt

Generic Name: dorzolamide and timolol (Ophthalmic route)

dor-ZOLE-a-mide hye-droe-KLOR-ide, TIM-oh-lol MAL-ee-ate

Commonly used brand name(s):

In the U.S.

  • Cosopt
  • Cosopt Ocumeter
  • Cosopt Ocumeter Plus

Available Dosage Forms:

  • Solution

Therapeutic Class: Antiglaucoma, Beta-Adrenergic Blocker/Carbonic Anhydrase Inhibitor Combination

Pharmacologic Class: Dorzolamide

Uses For Cosopt

Dorzolamide and timolol combination medicine contains a carbonic anhydrase inhibitor (dorzolamide) and a beta-adrenergic blocking agent (timolol). It is used in the eye to treat increased pressure in the eye caused by open-angle glaucoma and a condition called hypertension of the eye.

This medicine is available only with your doctor's prescription.

Before Using Cosopt

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

This medicine has been tested in children 2 years of age and older and, in effective doses, has not been shown to cause different side effects or problems than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of this medicine in the elderly with use in other age groups.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Albuterol
  • Amiodarone
  • Arformoterol
  • Bambuterol
  • Bitolterol
  • Broxaterol
  • Clenbuterol
  • Clonidine
  • Colterol
  • Diltiazem
  • Dronedarone
  • Epinephrine
  • Fenoldopam
  • Fenoterol
  • Fentanyl
  • Formoterol
  • Hexoprenaline
  • Isoetharine
  • Levalbuterol
  • Metaproterenol
  • Pirbuterol
  • Procaterol
  • Reproterol
  • Rimiterol
  • Ritodrine
  • Salmeterol
  • Terbutaline
  • Tretoquinol
  • Tulobuterol
  • Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Acetohexamide
  • Alfuzosin
  • Amlodipine
  • Arbutamine
  • Benfluorex
  • Bunazosin
  • Chlorpropamide
  • Cimetidine
  • Digoxin
  • Doxazosin
  • Felodipine
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Guar Gum
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Lacidipine
  • Lercanidipine
  • Manidipine
  • Metformin
  • Methyldopa
  • Mibefradil
  • Miglitol
  • Moxisylyte
  • Nicardipine
  • Nifedipine
  • Nilvadipine
  • Nimodipine
  • Nisoldipine
  • Nitrendipine
  • Phenoxybenzamine
  • Phentolamine
  • Pranidipine
  • Prazosin
  • Quinidine
  • Repaglinide
  • St John's Wort
  • Tamsulosin
  • Terazosin
  • Tolazamide
  • Tolbutamide
  • Trimazosin
  • Troglitazone
  • Urapidil

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy, history of—Severity and duration of allergic reactions to other substances may be increased
  • Asthma or
  • Bronchitis or
  • Emphysema or
  • Lung problems, other—This medicine can increase trouble in breathing
  • Bradycardia (unusually slow heartbeat) or
  • Heart problems, other—There is a risk of further decreased heart function
  • Diabetes mellitus (sugar diabetes) or
  • Hypoglycemia—If your blood sugar becomes too low, this medicine may cover up some of the symptoms
  • Kidney disease, severe—Effects of this medicine may be increased because of its slower removal from the body
  • Myasthenia gravis—This medicine may make this condition worse
  • Overactive thyroid—This medicine may cover up fast heartbeat, which is a sign of overactive thyroid

Proper Use of dorzolamide and timolol

This section provides information on the proper use of a number of products that contain dorzolamide and timolol. It may not be specific to Cosopt. Please read with care.

To use:

  • The bottle is only partially full to provide proper drop control.
  • First, wash your hands. Tilt the head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 1 or 2 minutes to allow the medicine to be absorbed by the eye.
  • Immediately after using the eye drops, wash your hands to remove any medicine that may be on them.
  • To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, keep the container tightly closed. Serious damage to the eye and possible loss of vision may result from using contaminated eye drops.

Use this medicine only as directed by your doctor. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of too much medicine being absorbed into the body and the chance of side effects.

If your doctor ordered two different eye drops to be used together, wait at least 10 minutes between the times you apply the medicines. This will help to keep the second medicine from “washing out” the first one.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For ophthalmic dosage form (eye drops):
    • For glaucoma or hypertension of the eye:
      • Adults—Use 1 drop of the medicine in the affected eye(s) two times a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Cosopt

It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly and is not causing unwanted effects.

If itching, redness, swelling, or other signs of eye or eyelid irritation occur, stop using this medicine and check with your doctor . These signs may mean that you are allergic to this medicine.

Before you have any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine. This medicine contains an ophthalmic beta-adrenergic blocking agent. Using an ophthalmic beta-adrenergic blocking agent during this time may cause an increased risk of side effects.

It is very important that you check with your doctor if you get an injury or infection in your eye or if you are scheduled to have eye surgery. Your doctor will tell you whether to keep using the same container of eye drops or whether you should start using a fresh bottle of eye drops.

For diabetic patients:

  • This medicine may cover up some signs of hypoglycemia (low blood sugar). If you notice a change in the results of your blood or urine sugar tests or if you have any questions, check with your doctor.

This medicine contains benzalkonium chloride, which may be absorbed by contact lenses. Take soft contact lenses out before using this medicine. Lenses may be put back in 15 minutes after using the medicine.

Cosopt Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common
  • Blurred vision
  • feeling of something in eye
  • itching of the eye
  • redness of eye and lining of eyelid
  • sensitivity of eyes to light
Less common
  • Back, abdominal, or stomach pain
  • change in vision
  • coughing, shortness of breath, troubled breathing, tightness in chest, or wheezing
  • discharge from eye
  • dizziness
  • eye or eyelid pain, swelling, discomfort, or irritation
  • increased blood pressure
  • increased frequency of urination or painful urination
  • itching of eyelid
  • seeing flashes or sparks of light
  • seeing floating spots before the eyes
  • swelling of lining of eyelid
  • tiny bumps on lining of eyelid
Rare
  • Blood in urine
  • blue lips, fingernails, or skin
  • chest pain or discomfort
  • diarrhea
  • difficult or troubled breathing
  • fainting
  • lightheadedness or fainting
  • headache or weakness, severe and sudden
  • irregular, fast or slow, or shallow breathing
  • mental depression
  • nausea or vomiting
  • pain, numbness, tingling, or burning feeling in hands or feet
  • shortness of breath
  • skin rash
  • slow or irregular heartbeat
  • sweating
  • unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Bitter, sour, or unusual taste
  • burning or stinging of the eye (when medicine is applied)
Less common
  • Cold- or flu-like symptoms
  • crusting or scales on eyelid
  • dryness of eyes
  • headache
  • indigestion or upset stomach
  • sore throat
  • stuffy or runny nose
  • tearing of eye

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • Cosopt Detailed Consumer Information (PDR)
  • Cosopt Drops MedFacts Consumer Leaflet (Wolters Kluwer)
  • Cosopt Consumer Overview

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