Generic Name: acetaminophen, chlorpheniramine, and codeine (a seet a MIN oh fen, klor fen IR a meen, KOE deen)Brand Names: Cotabflu
Acetaminophen is a pain reliever and fever reducer.
Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Codeine is a narcotic cough suppressant.
The combination of acetaminophen, chlorpheniramine, and codeine is used to treat runny nose, cough, and pain or fever caused by allergies or the common cold.Codeine will not treat a cough that is caused by smoking, asthma, or emphysema.
Acetaminophen, chlorpheniramine, and codeine may also be used for other purposes not listed in this medication guide.What is the most important information I should know about Cotabflu (acetaminophen, chlorpheniramine, and codeine)?Do not take this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take a cough and cold medicine before the MAO inhibitor has cleared from your body.
Do not take more of this medication than is recommended. An overdose of acetaminophen can cause damage to your liver. The maximum amount of acetaminophen for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. If you drink more than three alcoholic beverages per day, do not take this medication without your doctor's advice, and never take more than 2 grams (2000 mg) of acetaminophen per day.
Do not use any other cough, cold, or allergy medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains acetaminophen (sometimes abbreviate as "APAP") or chlorpheniramine.Do not give this medicine to a child without a doctor's advice. Death can occur from the misuse of cough or cold medicine in very young children. Always ask your doctor before treating a cough or cold in a child.What should I discuss with my healthcare provider before taking Cotabflu (acetaminophen, chlorpheniramine, and codeine)?
Do not use this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take a cough and cold medicine before the MAO inhibitor has cleared from your body.You should not use acetaminophen, chlorpheniramine, and codeine if you have ever had an allergic reaction to it, or if you have:
severe or uncontrolled high blood pressure;
severe coronary artery disease;
if you are unable to urinate;
if you are breast-feeding a baby; or
if you are having an asthma attack.
If you have certain conditions, you may need a dose adjustment or special tests to safely take acetaminophen, chlorpheniramine, and codeine. Before taking this medication, tell your doctor if you have:
heart disease or high blood pressure;
ischemic heart disease (reduced circulation of blood to the heart);
asthma, COPD, or other breathing disorder;
a thyroid disorder;
enlarged prostate, urination problems;
a stomach or intestinal disorder;
gallbladder disease or pancreatitis;
Addison's disease or other adrenal gland disorders;
a history of head injury or brain tumor;
epilepsy or other seizure disorder; or
if you have recently had surgery on your stomach, intestines, kidney, or bladder.
Take this medication exactly as it was prescribed for you. Do not take it in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label. Cough and cold medicine is usually taken for only a short time until your symptoms clear up.Take this medicine with food or milk if it upsets your stomach. An overdose of acetaminophen can cause serious harm. The maximum amount of acetaminophen for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Taking more acetaminophen could cause damage to your liver. Know the amount of acetaminophen in the specific product you are taking. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.
Chlorpheniramine can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash. Store the medicine at room temperature, away from heat, light, and moisture.
Keep track of how many pills have been used from each bottle of this medication. Codeine is a drug of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.
Since cough or cold medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Overdose symptoms may include extreme dizziness, drowsiness, nausea, vomiting, stomach pain, loss of appetite, increased sweating, pinpoint pupils, confusion, cold and clammy skin, blue-colored lips or fingernails, weak pulse, shallow breathing, seizure (convulsions), fainting, or breathing that stops.What should I avoid while taking Cotabflu (acetaminophen, chlorpheniramine, and codeine)?This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Do not use any other cough, cold, pain, or allergy medication without first asking your doctor or pharmacist. Acetaminophen (sometimes abbreviated as "APAP") and chlorpheniramine are contained in many combination medicines. If you take certain products together you may accidentally take too much of a certain drug. Read the label of any other medicine you are using to see if it contains acetaminophen, APAP, or chlorpheniramine.Avoid drinking alcohol. It can increase some side effects of chlorpheniramine and codeine, and increases your risk of liver damage while taking acetaminophen. If you drink more than three alcoholic beverages per day, do not take acetaminophen without your doctor's advice, and never take more than 2 grams (2000 mg) of acetaminophen per day. Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). This medication can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.
severe weakness, dizziness, anxiety, restless feeling, or nervousness;
confusion, hallucinations, unusual thoughts or behavior;
chest pain or tightness;
fast, pounding, or uneven heartbeats;
slow heart rate, weak pulse, fainting, weak or shallow breathing;
signs of infection such as fever, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums);
urinating less than usual or not at all; or
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
dry eyes, blurred vision;
dry mouth, upset stomach, constipation;
warmth, tingling, or redness under your skin;
restless or excitability (especially in children);
increased sweating; or
mild skin rash or itching.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.What other drugs will affect Cotabflu (acetaminophen, chlorpheniramine, and codeine)?Before taking this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine or codeine.
Also tell your doctor if you are using any of the following drugs:
a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton); or
an antidepressant such as amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Janimine, Tofranil), and others.
This list is not complete and there may be other drugs that can interact with acetaminophen, chlorpheniramine, and codeine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.