Trade Names:Seromycin Pulvules- Capsules 250 mg
Inhibits cell wall synthesis in susceptible strains of certain microorganisms.
Readily absorbed. T max is 4 to 8 h.
Widely distributed in tissues (eg, CSF, pleural fluid).
35% metabolized to unknown metabolites.
About 65% of a single dose is excreted in urine within 72 h. Maximum excretion rate occurs 2 to 6 h after dose, with 50% eliminated in 12 h.
Treatment of active pulmonary and extrapulmonary tuberculosis when organisms are susceptible (after failure of adequate treatment with primary medications); treatment of UTIs caused by susceptible bacteria when conventional therapy has failed; treatment of Gaucher disease.
Epilepsy; depression; severe anxiety or psychosis; severe renal function impairment; excessive concurrent use of alcohol.
PO 250 to 500 mg every 12 h; start with 250 mg every 12 h for first 2 wk (max, 1 g/day).Children
PO 15 to 20 mg/kg/day administered in 2 equally divided doses (max, 1 g/day).
Administer with meals if GI upset occurs.
Store in airtight, light-resistant container at room temperature.
Increases possibility and risk of epileptic episodes. Do not use together.Isoniazid
May increase cycloserine CNS adverse reactions (eg, dizziness).
None well documented.
Convulsions; drowsiness; somnolence; headache; tremor; dysarthria; vertigo; confusion; loss of memory; psychoses with suicidal tendencies, behavior changes, hyperirritability, aggression, paresis; hyperreflexia; paresthesias; major and minor clonic seizures; coma; dizziness.
Elevated hepatic transaminase.
Obtain culture before treatment and verify susceptibility when results are available.Therapeutic effectiveness
In patients with tuberculosis, assess for therapeutic effectiveness by monitoring clinical signs and symptoms, sputum cultures, or smears for acid-fast bacilli and chest x-rays.UTI
In patients with UTIs, assess for therapeutic effectiveness by monitoring clinical signs and symptoms and urine cultures.
Category C .
Safety and dosage not well established.
Determine weekly blood levels of drug and adjust dosage to keep blood levels below 30 mcg/mL.
Discontinue drug or decrease dosage if symptoms of CNS toxicity develop. May be increased with excessive alcohol consumption. Pyridoxine 200 to 300 mg/day may be given to prevent neurotoxic effects.
CNS depression, drowsiness, mental confusion, headache, vertigo, hyperirritability, paresthesias, dysarthrias, psychosis, paresis, convulsions, coma.
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