Generic Name: darunavir (da ROON a veer)Brand Names: Prezista
Darunavir is an antiviral medication in a group of HIV medicines called protease (PRO-tee-ayz) inhibitors. Darunavir prevents human immunodeficiency virus (HIV) cells from multiplying in your body.
Darunavir is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Darunavir is not a cure for HIV or AIDS.
Darunavir may also be used for other purposes not listed in this medication guide.
There are many other medicines that can interact with darunavir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.
HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.Avoid having unprotected sex or sharing needles, razors, or toothbrushes. Taking darunavir will not prevent you from passing HIV to other people. Talk with your doctor about safe methods of preventing HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
You should not take this medication if you are allergic to darunavir.Some drugs can cause life-threatening side effects if you use them while you are taking darunavir. Do not take darunavir with:
astemizole (Hismanal) or terfenadine (Seldane);
lovastatin (Mevacor) or simvastatin (Zocor);
rifampin (Rifadin, Rimactane, Rifater);
triazolam (Halcion) or oral midazolam (Versed);
St. John's wort; or
ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take darunavir:
a bleeding disorder such as hemophilia; or
high cholesterol or triglycerides.
Your name may need to be listed on an antiviral pregnancy registry when you start using this medication.Taking darunavir together with birth control pills can make the darunavir less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking darunavir. You should not breast-feed while you are using darunavir. Women with HIV or AIDS should not breast-feed at all. Even if your baby is born without HIV, you may still pass the virus to the baby in your breast milk.
Take darunavir exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Darunavir must be taken together with another medication called ritonavir (Norvir).
This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.Take this medicine with a full glass (8 ounces) of water or milk. Darunavir and ritonavir is most effective when taken with food.
Swallow the darunavir tablet whole.
It is important to use darunavir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your liver function may also need to be tested., especially if you have hepatitis B or C. Do not miss any follow-up visits to your doctor.
HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.Store darunavir at room temperature away from moisture and heat.
See also: Darunavir dosage in more detail
Take the missed dose of darunavir and ritonavir as soon as you remember and take your next dose at the regularly scheduled time.
If you take darunavir 800 milligrams once daily and you are more than 12 hours late in taking your medications, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.
If you take darunavir 600 milligrams twice daily and you are more than 6 hours late in taking your medications, skip the missed dose and take the next regularly scheduled dose.
Always take darunavir and ritonavir together. Do not take extra medicine to make up the missed dose.
If you also take didanosine, take it 1 hour before or 2 hours after you take darunavir.Avoid having unprotected sex or sharing needles, razors, or toothbrushes. Taking this medication will not prevent you from passing HIV to other people. Talk with your doctor about safe methods of preventing HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
the first sign of any skin rash, no matter how mild;
increased urination or extreme thirst;
signs of a new infection, such as fever or chills, cough, flu symptoms, easy bruising or bleeding;
severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate; or
nausea, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
diarrhea, bloating, upset stomach, mild stomach pain;
changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for HIV Infection:
Therapy-naive: Darunavir 800 mg plus ritonavir 100 mg orally once a day with foodTherapy-experienced: Darunavir 600 mg plus ritonavir 100 mg orally twice a day with food
Usual Pediatric Dose for HIV Infection:
6 to less than 18 years:20 to less than 30 kg: Darunavir 375 mg plus ritonavir 50 mg orally twice a day with food30 to less than 40 kg: Darunavir 450 mg plus ritonavir 60 mg orally twice a day with food40 kg or more: Darunavir 600 mg plus ritonavir 100 mg orally twice a day with food
buprenorphine and naloxone (Suboxone);
methadone (Methadose, Dolophine, Diskets);
risperidone (Risperdal) or thioridazine (Mellaril);
an antibiotic such as clarithromycin (Biaxin), rifabutin (Mycobutin), or rifampin (Rifadin, Rimactane, Rifater);
an antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
an antidepressant such as desipramine (Norpramin), paroxetine (Paxil), sertraline (Zoloft), trazodone (Desyrel), and others;
beta-blockers such as metoprolol (Lopressor, Toprol) or timolol (Blocadren, Betimol, Cosopt, Timoptic);
a blood thinner such as warfarin (Coumadin);
a calcium channel blocker such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others;
cholesterol-lowering medicine such as atorvastatin (Lipitor) pravastatin (Pravachol), rosuvastatin (Crestor);
drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);
a heart rhythm medication such as amiodarone (Cordarone), digoxin (digitalis, Lanoxin), flecainide (Tambocor), lidocaine, propafenone (Rythmol), or quinidine (Quinaglute, Quinidex);
insulin or diabetes medication you take by mouth;
medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);
other HIV /AIDS medicine such as efavirenz (Sustiva), lopinavir/ritonavir (Kaletra), or saquinavir (Invirase, Fortovase);
seizure medications such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin); or
a steroid medication such as dexamethasone (Decadron, Hexadrol) or fluticasone (Advair, Flonase, Flovent).
This list is not complete and there are many other medicines that can interact with darunavir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.