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Drugs reference index «AbobotulinumtoxinA»


Generic Name: AbobotulinumtoxinA (A-bo-BOT-ue-li-num-TOX-in-A)Brand Name: Dysport

AbobotulinumtoxinA may spread from the injection site to other areas of the body, causing symptoms of a serious condition called botulism. These symptoms may occur hours to weeks after you receive AbobotulinumtoxinA . Symptoms may include loss of strength; muscle weakness; double or blurred vision; drooping eyelids; hoarseness; loss of voice; loss of bladder control; or trouble speaking, breathing, or swallowing. The risk may be greater in children being treated for spasticity (muscle spasms), but these symptoms may also occur in adults. Contact your doctor immediately if these symptoms occur.

AbobotulinumtoxinA is used for:

Reducing the severity of abnormal head position and neck pain associated with neck problems. It is also used to temporarily improve the appearance of moderate to severe lines between the eyebrows in patients 65 years old or younger. It may also be used for other conditions as determined by your doctor.

AbobotulinumtoxinA is a neurotoxin. It works by blocking nerve impulses to the muscles, which temporarily paralyzes the muscle or gland.

Do NOT use AbobotulinumtoxinA if:

  • you are allergic to any ingredient in AbobotulinumtoxinA , another botulinum product, or cow's milk
  • you have an infection at the injection site

Contact your doctor or health care provider if any of these apply to you.

Before using AbobotulinumtoxinA :

Some medical conditions may interact with AbobotulinumtoxinA . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have nerve problems or disease (eg, amyotrophic lateral sclerosis, motor neuropathy), muscle problems or disease (eg, myasthenia gravis, Lambert-Eaton syndrome), seizures, or bleeding disorders
  • if you have a history of heart problems (eg, irregular heartbeat, recent heart attack), swallowing or breathing problems (eg, asthma), eye problems (eg, glaucoma), or diabetes
  • if you have a skin infection, inflammation, scarring, or other skin disorders at the injection site
  • if you have severe weakness or wasting of the muscles at the injection site (eg, trouble raising eyebrows, drooping eyelids) or if you have had a change in the shape of your face
  • if you have had surgery on your face, or if you are planning to have any type of surgery
  • if you have received AbobotulinumtoxinA or any other botulinum toxin in the past 4 months
  • if you take an allergy or cold medicine, or a medicine to help you sleep

Some MEDICINES MAY INTERACT with AbobotulinumtoxinA . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aminoglycosides (eg, gentamicin), anticholinesterase medicines (eg, neostigmine), lincosamides (eg, clindamycin), magnesium, muscle relaxants (eg, cyclobenzaprine), neuromuscular blockers (eg, atracurium), polymyxin, or quinidine because the risk of toxic effects may be increased
  • Anticholinergics (eg, scopolamine) because the risk of their side effects may be increased by AbobotulinumtoxinA

This may not be a complete list of all interactions that may occur. Ask your health care provider if AbobotulinumtoxinA may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use AbobotulinumtoxinA :

Use AbobotulinumtoxinA as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • AbobotulinumtoxinA comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get AbobotulinumtoxinA refilled.
  • AbobotulinumtoxinA is usually given as an injection at your doctor's office, hospital, or clinic.
  • Do not use AbobotulinumtoxinA if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • If you miss a dose of AbobotulinumtoxinA , contact your doctor right away.

Ask your health care provider any questions you may have about how to use AbobotulinumtoxinA .

Important safety information:

  • AbobotulinumtoxinA may cause dizziness, vision changes, sensitivity to light, drooping eyelids, or muscle weakness. These effects may be worse if you take it with alcohol or certain medicines. Use AbobotulinumtoxinA with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT use more than the recommended dose, more often than recommended, or for longer than prescribed without checking with your doctor.
  • Do not switch brands of AbobotulinumtoxinA . Contact your doctor if you have any questions.
  • Severe and sometimes fatal breathing or swallowing problems have been reported in patients using AbobotulinumtoxinA . The risk may be greater in patients who already have breathing or swallowing problems. Tell your doctor if you have or are at risk of developing breathing or swallowing problems.
  • AbobotulinumtoxinA contains albumin, which comes from human blood. There is a very rare risk of getting a viral disease or a central nervous system disease called Creutzfeldt-Jakob disease from products with albumin. No cases of these problems have been found in patients who have used AbobotulinumtoxinA .
  • Tell your doctor or dentist that you take AbobotulinumtoxinA before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - AbobotulinumtoxinA may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • To prevent injury, resume normal activities gradually after using AbobotulinumtoxinA .
  • Use AbobotulinumtoxinA with caution in the ELDERLY; they may be more sensitive to its effects, especially eye problems.
  • AbobotulinumtoxinA should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using AbobotulinumtoxinA while you are pregnant. It is not known if AbobotulinumtoxinA is found in breast milk. If you are or will be breast-feeding while you use AbobotulinumtoxinA , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of AbobotulinumtoxinA :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry mouth; fatigue; headache; nausea; neck pain; pain, redness, swelling, or tenderness at the injection site; sinus inflammation; sore throat; stiff or weak muscles at or near the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bleeding at the injection site; difficulty swallowing or breathing; dizziness; drooping of the upper eyelid; eyelid swelling; facial paralysis; fainting; loss of bladder control; loss of strength; seizures; severe or persistent muscle weakness; shortness of breath; slow heartbeat; speech changes or problems; vision changes or problems (eg, double or blurred vision, inability to focus the eyes, decreased vision); wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include severe muscle weakness or paralysis. Symptoms may not occur for up to several weeks after an overdose.

Proper storage of AbobotulinumtoxinA :

AbobotulinumtoxinA is usually handled and stored by a health care provider. If you are using AbobotulinumtoxinA at home, store AbobotulinumtoxinA as directed by your pharmacist or health care provider. Keep AbobotulinumtoxinA out of the reach of children and away from pets.

General information:

  • If you have any questions about AbobotulinumtoxinA , please talk with your doctor, pharmacist, or other health care provider.
  • AbobotulinumtoxinA is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about AbobotulinumtoxinA . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Botox Consumer Overview
  • Botox Prescribing Information (FDA)
  • Botox Advanced Consumer (Micromedex) - Includes Dosage Information
  • Botulinum Toxin Type A Professional Patient Advice (Wolters Kluwer)
  • Dysport Prescribing Information (FDA)
  • Dysport Advanced Consumer (Micromedex) - Includes Dosage Information
  • Dysport Consumer Overview

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