Drugs Information Online
Drugs and diseases reference index

Drugs and diseases reference index
Search
EN

Drugs reference index «deferoxamine Injection»

deferoxamine (Injection route)

de-fer-OX-a-meen

Commonly used brand name(s):

In the U.S.

  • Desferal

Available Dosage Forms:

  • Powder for Solution

Therapeutic Class: Heavy Metal Chelator

Uses For deferoxamine

Deferoxamine is used to remove excess iron from the body. This may be necessary in certain patients with anemia who must receive many blood transfusions. It is also used to treat acute iron poisoning, especially in small children.

Deferoxamine combines with iron in the bloodstream. The combination of iron and deferoxamine is then removed from the body by the kidneys. By removing the excess iron, the medicine lessens damage to various organs and tissues of the body. deferoxamine may be used for other conditions as determined by your doctor.

Deferoxamine is to be administered only by or under the immediate supervision of your doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in product labeling, deferoxamine is used in certain patients with the following medical condition:

  • Aluminum toxicity (too much aluminum in the body)

Before Using deferoxamine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For deferoxamine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to deferoxamine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Deferoxamine is not used for long-term treatment of children up to 3 years of age. Also, younger patients are more likely to develop hearing and vision problems with the use of deferoxamine in high doses for a long time.

Geriatric

The combination of deferoxamine and vitamin C should be used with caution in older patients, since this combination may be more likely to cause heart problems in these patients than in younger adults.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of deferoxamine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Kidney disease—Patients with kidney disease may be more likely to have side effects

Proper Use of deferoxamine

Deferoxamine may sometimes be given at home to patients who do not need to be in the hospital. If you are receiving deferoxamine at home, make sure you clearly understand and carefully follow your doctor's instructions.

Dosing

The dose of deferoxamine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of deferoxamine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form:
    • For acute iron toxicity:
      • Adults and children over 3 years of age—Dose is based on body weight and must be determined by your doctor. The usual dose is 90 milligrams (mg) per kilogram (kg) (41 mg per pound) of body weight, followed by 45 mg per kg (20 mg per pound) of body weight, injected into a muscle every four to twelve hours. If it is injected into a vein, the usual dose is 15 mg per kg (7 mg per pound) of body weight per hour every eight hours.
      • Children up to 3 years of age—The usual dose is 15 mg per kg (7 mg per pound) of body weight per hour, injected into a vein.
    • For chronic iron toxicity:
      • Adults and children over 3 years of age—The usual dose is 500 mg to 1 gram a day, injected into a muscle. Or, the medicine may be injected under the skin by an infusion pump. The usual dose is 1 to 2 grams (20 to 40 mg per kg [9 to 18 mg per pound] of body weight) a day, injected under the skin, over a period of eight to twenty-four hours. If you are receiving blood transfusions, the usual dose is 500 mg to 1 gram a day, injected into a muscle. An extra 2 grams of the medicine is injected into a vein with each unit of blood at a rate of 15 mg per kg of body weight per hour.
      • Children up to 3 years of age—Use and dose must be determined by your doctor. The usual dose is 10 mg per kg (5 mg per pound) of body weight a day, injected under the skin.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not refrigerate. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Store the mixed medicine at room temperature for no longer than recommended by your doctor or the manufacturer.

Precautions While Using deferoxamine

It is important that your doctor check your progress at regular visits to make sure that deferoxamine is working properly and to prevent unwanted effects. Certain blood and urine tests must be done regularly to check for the need for dosage changes.

Deferoxamine may cause some people, especially younger patients, to have hearing and vision problems within a few weeks after they start taking it. If you notice any problems with your vision, such as blurred vision, difficulty in seeing at night, or difficulty in seeing colors, or difficulty with your hearing, check with your doctor as soon as possible . The dose of deferoxamine may need to be adjusted.

Do not take vitamin C unless your doctor has told you to do so.

deferoxamine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common
  • Bluish fingernails, lips, or skin
  • blurred vision or other problems with vision
  • convulsions (seizures)
  • difficulty in breathing (wheezing), or fast breathing
  • fast heartbeat
  • hearing problems
  • pain or swelling at place of injection
  • redness or flushing of skin
  • skin rash, hives, or itching
Less common
  • Diarrhea
  • difficult urination
  • fever
  • leg cramps
  • stomach and muscle cramps
  • stomach discomfort
  • unusual bleeding or bruising

Hearing and vision problems are more likely to occur in younger patients taking high doses and on long-term treatment.

Deferoxamine may cause the urine to turn orange-rose in color. This is to be expected while you are using deferoxamine.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

Comment «deferoxamine Injection»