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Drugs reference index «Definity»

Definity

Generic Name: perflutren lipid microsphere (Intravenous route)

per-FLOO-tren LIP-id MYE-kroe-sfeers

Injection routeSuspension
  • Serious cardiopulmonary reactions, including fatalities, have occurred during or following perflutren-containing microsphere administration.
    • Assess all patients for the presence of any condition that precludes perflutren lipid microsphere administration.
    • In patients with pulmonary hypertension or unstable cardiopulmonary conditions, monitor vital sign measurements, electrocardiography and cutaneous oxygen saturation during and for at least 30 minutes after perflutren lipid microsphere administration.
    • Always have resuscitation equipment and trained personnel readily available .

Serious or fatal cardiopulmonary reactions have occurred during or following perflutren lipid microsphere administration. Monitor vital signs, electrocardiography, and cutaneous oxygen saturation during and for at least 30 minutes after perflutren lipid microsphere administration in patients with pulmonary hypertension or unstable cardiopulmonary conditions, and have resuscitation equipment and trained personnel available .

Commonly used brand name(s):

In the U.S.

  • Definity

Available Dosage Forms:

  • Suspension

Therapeutic Class: Radiological Non-Ionic Contrast Media

Uses For Definity

Perflutren lipid microsphere preparation is an ultrasound contrast agent. Ultrasound contrast agents are used to help provide a clear picture during ultrasound. Ultrasound is a special kind of diagnostic procedure. It uses high-frequency sound waves to create images or “pictures” of certain areas inside the body. The sound waves produced by the ultrasound equipment can be reflected (bounced off) by different parts of the body, like for example, the heart. As the sound waves return they are electronically converted into images on a television screen. Unlike x-rays, ultrasound does not involve ionizing radiation.

The perflutren lipid microspheres preparation contains very small gas-filled lipid microspheres that reflect the sound waves and help create a better picture. The lipid microsphere preparation is given by injection into a vein before ultrasound to help diagnose problems of the heart.

The lipid microsphere preparation is to be given only by or under the direct supervision of a doctor with specialized training in ultrasound procedures.

This medicine is available only with your doctor's prescription.

Before Using Definity

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

In deciding to use a diagnostic agent, any risks of the test must be weighed against the good it will do. This is a decision you and your doctor will make. Also, test results may be affected by other things. For the perflutren lipid microspheres preparation, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this agent have been done only in adult patients, and there is no specific information comparing use of perflutren lipid microspheres in children with use in other age groups.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. There is no specific information comparing use of perflutren lipid microspheres in the elderly with use in other age groups.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Heart shunt—perflutren lipid microspheres can bypass filtering by the lungs and directly enter the blood stream and be trapped in small blood vessels
  • Lung disease, especially emphysema, pulmonary vasculitis or any conditions that lower the lung area that comes in contact with the blood or
  • Respiratory distress syndrome—May increase the side effects of perflutren lipid microsphere

Proper Use of Definity

Your doctor may have special instructions for you in preparation for your test. If you do not understand the instructions you receive or if you have not received such instructions, check with your doctor in advance.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Precautions While Using Definity

There are no special precautions to observe after having this test.

Definity Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare
  • Black, tarry stools
  • blurred vision
  • chest pain
  • chills
  • difficult breathing
  • dizziness, severe or continuing
  • fast, pounding, or irregular heartbeat or pulse
  • hives
  • itching
  • lightheadedness when getting up from a lying or sitting position
  • palpitations
  • shortness of breath
  • skin rash
  • slow or irregular heartbeat
  • swollen glands
  • unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Back pain
  • feeling of warmth on skin
  • headache
  • nausea
  • redness of the face, neck arms and occasionally, upper chest
Rare
  • Acid or sour stomach
  • bruising
  • diarrhea
  • difficulty in moving
  • dizziness
  • dryness of the mouth
  • feeling of constant movement of self or surroundings
  • fever
  • heartburn
  • indigestion
  • leg cramps
  • muscle stiffness or tension
  • pain at injection site
  • pain or swelling in the joints
  • prickly or tingling sensation
  • sneezing or runny nose
  • stomach upset or pain
  • unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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  • Definity Prescribing Information (FDA)
  • Definity MedFacts Consumer Leaflet (Wolters Kluwer)
  • Perflutren Professional Patient Advice (Wolters Kluwer)
  • Optison Prescribing Information (FDA)
  • Optison MedFacts Consumer Leaflet (Wolters Kluwer)

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