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Drugs reference index «desvenlafaxine»

desvenlafaxine (Oral route)

des-ven-la-FAX-een

Oral routeTablet, Extended Release
  • Suicidality and Antidepressant Drugs
    • Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of Major Depressive Disorder (MDD) and other psychiatric disorders. Anyone considering the use of desvenlafaxine or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Desvenlafaxine succinate is not approved for use in pediatric patients .

Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies with major depressive disorder (MDD) and other psychiatric disorders. Short term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. This risk must be balanced with the clinical need. Monitor patients closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Not approved for use in pediatric patients .

Commonly used brand name(s):

In the U.S.

  • Pristiq

Available Dosage Forms:

  • Tablet, Extended Release

Therapeutic Class: Antidepressant

Pharmacologic Class: Serotonin/Norepinephrine Reuptake Inhibitor

Uses For desvenlafaxine

Desvenlafaxine is used to treat mental depression .

Desvenlafaxine belongs to a group of medicines known as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). These medicines are thought to work by increasing the activity of chemicals called serotonin and norepinephrine in the brain .

desvenlafaxine is available only with your doctor's prescription .

Before Using desvenlafaxine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For desvenlafaxine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to desvenlafaxine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of desvenlafaxine in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of desvenlafaxine in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment of dosage in patients receiving desvenlafaxine .

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using desvenlafaxine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Clorgyline
  • Isocarboxazid
  • Lazabemide
  • Linezolid
  • Metoclopramide
  • Moclobemide
  • Pargyline
  • Phenelzine
  • Procarbazine
  • Rasagiline
  • Selegiline
  • Tranylcypromine

Using desvenlafaxine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abciximab
  • Acenocoumarol
  • Almotriptan
  • Anagrelide
  • Ancrod
  • Anisindione
  • Antithrombin III Human
  • Aspirin
  • Avitriptan
  • Bivalirudin
  • Cilostazol
  • Citalopram
  • Clopidogrel
  • Clovoxamine
  • Danaparoid
  • Defibrotide
  • Dermatan Sulfate
  • Desirudin
  • Dicumarol
  • Dipyridamole
  • Duloxetine
  • Eletriptan
  • Epoprostenol
  • Eptifibatide
  • Escitalopram
  • Femoxetine
  • Fluoxetine
  • Fluvoxamine
  • Fondaparinux
  • Frovatriptan
  • Heparin
  • Iloprost
  • Lamifiban
  • Lexipafant
  • Milnacipran
  • Naratriptan
  • Nefazodone
  • Paroxetine
  • Pentosan Polysulfate Sodium
  • Phenindione
  • Phenprocoumon
  • Rizatriptan
  • Sertraline
  • Sibrafiban
  • Sibutramine
  • Sulfinpyrazone
  • Sulodexide
  • Sumatriptan
  • Tapentadol
  • Ticlopidine
  • Tirofiban
  • Tramadol
  • Tryptophan
  • Venlafaxine
  • Warfarin
  • Xemilofiban
  • Zimeldine
  • Zolmitriptan

Using desvenlafaxine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Aceclofenac
  • Acemetacin
  • Alclofenac
  • Benoxaprofen
  • Bromfenac
  • Bufexamac
  • Carprofen
  • Celecoxib
  • Clonixin
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Dipyrone
  • Droxicam
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Felbinac
  • Fenbufen
  • Fenoprofen
  • Fentiazac
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Ibuprofen
  • Indomethacin
  • Indoprofen
  • Isoxicam
  • Ketoprofen
  • Ketorolac
  • Lornoxicam
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Morniflumate
  • Nabumetone
  • Naproxen
  • Niflumic Acid
  • Nimesulide
  • Oxaprozin
  • Parecoxib
  • Phenylbutazone
  • Pirazolac
  • Piroxicam
  • Pirprofen
  • Propyphenazone
  • Proquazone
  • Rofecoxib
  • Sulindac
  • Suprofen
  • Tenidap
  • Tenoxicam
  • Tiaprofenic Acid
  • Tolmetin
  • Valdecoxib
  • Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using desvenlafaxine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use desvenlafaxine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of desvenlafaxine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bipolar disorder (mental disease with cycles of elation and depression), history of, or
  • Bleeding problems or
  • Glaucoma (e.g., acute narrow-angle) or
  • High blood pressure or
  • Hypercholesterolemia (high cholesterol in the blood) or
  • Hypomania (mild form of mania), or history of or
  • Hyponatremia (low sodium in the blood) or
  • Mania (feeling elated), or history of or
  • Seizure (convulsions), history of—May make these conditions worse .
  • Heart attack, recent or
  • Heart disease or
  • Stroke, history of—Use with caution. May cause an increase in heart rate .
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body .

Proper Use of desvenlafaxine

Take desvenlafaxine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered .

Desvenlafaxine may be taken with or without food, and should be taken at the same time of day every day .

Swallow the extended-release tablet whole with a liquid. Do not dissolve, crush, break, or chew it .

desvenlafaxine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one .

Dosing

The dose of desvenlafaxine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of desvenlafaxine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For mental depression:
    • For oral dosage form (extended-release tablets):
      • Adults—50 milligrams (mg) once a day. Your doctor may adjust your dose if needed.
      • Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of desvenlafaxine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using desvenlafaxine

It is important that your doctor check your progress at regular visits, to allow for changes in your dose and to help reduce any side effects .

Desvenlafaxine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you, your child, or your caregiver notice any of these side effects, tell your doctor or your child's doctor right away .

Do not stop taking desvenlafaxine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are taking before stopping it completely to decrease the chance of side effects .

Do not take desvenlafaxine within 2 weeks (14 days) of taking a monoamine oxidase (MAO) inhibitor (e.g., isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], or tranylcypromine [Parnate®]). Do not take an MAO inhibitor for at least 7 days after taking desvenlafaxine. Talk to your doctor about this if you have questions .

Make sure your doctor knows about all the other medicines you are using. Desvenlafaxine may cause a serious condition called serotonin syndrome when taken with certain medicines such as linezolid [e.g., Zyvox®], lithium, tryptophan, St. John's Wort, or some pain or migraine medicines (e.g., tramadol [Ultram®], sumatriptan [Imitrex®], zolmitriptan [Zomig®], or rizatriptan [Maxalt®]). Check with your doctor first before taking any other medicines .

You should not use alcohol while you are taking desvenlafaxine .

Check with your doctor right away if you develop any allergic reactions to desvenlafaxine such as rash, hives, swelling, or difficulty breathing .

desvenlafaxine may cause serious lung problems. Check with your doctor right away and stop using desvenlafaxine if you have chest discomfort or tightness, a cough, difficult or labored breathing, shortness of breath, or wheezing .

desvenlafaxine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to desvenlafaxine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

desvenlafaxine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common
  • Dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • headache
  • numbness or tingling in arms or legs
  • shakiness in legs, arms, hands, feet
  • trembling or shaking of hands or feet
  • trouble thinking, speaking or walking
  • weakness
Incidence not known
  • Actions that are out of control
  • bigger, dilated, or enlarged pupils (black part of the eye)
  • blood in stool
  • blood in urine
  • convulsions
  • fever
  • hives
  • hoarseness
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • loss of bladder control
  • muscle spasm or jerking of all extremities
  • nose bleeds
  • rash
  • redness of skin
  • shortness of breath
  • sudden loss of consciousness
  • swelling of eyelids, face, lips, hands, or feet
  • talking, feeling, and acting with excitement
  • tightness in chest
  • troubled breathing or swallowing
  • unusual bruising
  • vomiting blood
  • wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose
  • Abdominal pain
  • bloating of abdomen
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • confusion
  • dark-colored urine
  • diarrhea
  • difficulty having a bowel movement (stool)
  • dry mouth
  • feeling of constant movement of self or surroundings
  • hyperventilation
  • light-colored stools
  • muscle cramps, pain, or stiffness
  • nausea
  • overactive reflexes
  • poor coordination
  • restlessness
  • sensation of spinning
  • shivering
  • slow heartbeat
  • sweating
  • twitching
  • unusual tiredness or weakness
  • vomiting
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Decreased appetite
  • decreased interest in sexual intercourse
  • inability to have or keep an erection
  • longer than usual time to ejaculation of semen
  • loss in sexual ability, desire, drive, or performance
  • not able to have an orgasm
  • sleepiness or unusual drowsiness
  • sleeplessness
Less common
  • Change in taste
  • change or problem with discharge of semen
  • chills
  • continuing ringing or buzzing or other unexplained noise in ears
  • decreased weight
  • difficult urination
  • fear or nervousness
  • feeling of warmth
  • hearing loss
  • increased sensitivity of eyes to light
  • jitteriness
  • lack or loss of strength
  • loss of taste
  • not able to ejaculate semen
  • yawning

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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  • Desvenlafaxine Extended-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)
  • Pristiq Prescribing Information (FDA)
  • Pristiq Consumer Overview

See Also...

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