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Drugs reference index «Dexrazoxane»



Generic Name: Dexrazoxane (dex-ra-ZOX-ane)Brand Name: Zinecard

Dexrazoxane is used for:

Reducing the incidence and severity of heart problems associated with the chemotherapy agent doxorubicin in women being treated for metastatic breast cancer.

Dexrazoxane is a cardioprotective agent. Exactly how Dexrazoxane works is unknown, but it works by interfering with harmful chemicals inside of cells that are thought to be partially responsible for heart problems caused by doxorubicin.

Do NOT use Dexrazoxane if:

  • you are allergic to any ingredient in Dexrazoxane
  • you are taking other chemotherapy that does not contain doxorubicin or a similar therapy

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dexrazoxane :

Some medical conditions may interact with Dexrazoxane . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have drug-induced bone marrow suppression or kidney or liver problems

Some MEDICINES MAY INTERACT with Dexrazoxane . However, no specific interactions with Dexrazoxane are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dexrazoxane may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dexrazoxane :

Use Dexrazoxane as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Dexrazoxane is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Dexrazoxane at home, carefully follow the injection procedures taught to you by your health care provider.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • Wear gloves while handling this medication. If the powder or solution comes into contact with the skin wash thoroughly with soap and water or rinse eyes with water.
  • If you miss a dose of Dexrazoxane , contact your doctor right away.

Ask your health care provider any questions you may have about how to use Dexrazoxane .

Important safety information:

  • LAB TESTS, such as kidney or liver function tests and blood tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Dexrazoxane with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Dexrazoxane during pregnancy. It is unknown if Dexrazoxane is excreted in breast milk. Do not breast-feed while taking Dexrazoxane .

Possible side effects of Dexrazoxane :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; difficulty swallowing; fever; general body discomfort; hair loss; infection (chills; sore throat); loss of appetite; nausea; pain or swelling at the injection site; streaking or flushing of the skin; swelling of the throat or tongue; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately.

Proper storage of Dexrazoxane :

Once mixed, the solution can be stored for 6 hours at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), or in a refrigerator at 36 to 46 degrees F (2 to 8 degrees C). Throw away any unused solution. Store powder at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Dexrazoxane out of the reach of children and away from pets.

General information:

  • If you have any questions about Dexrazoxane , please talk with your doctor, pharmacist, or other health care provider.
  • Dexrazoxane is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Dexrazoxane . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Dexrazoxane Prescribing Information (FDA)
  • Dexrazoxane Professional Patient Advice (Wolters Kluwer)
  • dexrazoxane Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
  • Totect Consumer Overview
  • Totect Prescribing Information (FDA)
  • Zinecard Prescribing Information (FDA)

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