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Drugs reference index «Dextroamphetamine Sulfate»

Dextroamphetamine Sulfate

Pronunciation: (DEX-troe-am-FET-uh-meen SULL-fate)Class: Amphetamine

Trade Names:Dexedrine- Tablets 5 mg

Trade Names:Dexedrine Spansules- Capsules, sustained-release 5 mg- Capsules, sustained-release 10 mg- Capsules, sustained-release 15 mg

Trade Names:Dextrostat- Tablets 5 mg


Activates noradrenergic neurons causing CNS and respiratory stimulation; stimulates satiety center in brain causing appetite suppression.



Well absorbed. T max approximately 3 h (IR tablets) and approximately 8 h (SR capsules).


Widely distributed with high concentrations in the brain.


Metabolized in the liver by hydroxylation, N-deakylation and deamination.


t ½ approximately 12 h (urine pH less than 5.6, t ½ is 7 to 8 h; urine pH alkaline, t ½ is 18.6 to 33.6 h).

Indications and Usage

Treatment of narcolepsy, attention-deficit disorder with hyperactivity; adjunct therapy for short-term (ie, few weeks) exogenous obesity when alternative therapy has been ineffective.


Advanced arteriosclerosis; symptomatic CV disease; moderate to severe hypertension; hyperthyroidism; hypersensitivity or idiosyncratic reactions to sympathomimetic amines; glaucoma; agitated states; history of drug abuse; concurrent use or within 14 days of MAOI use.

Dosage and Administration

NarcolepsyAdults (older than 12 yr of age)

PO 10 mg/day; may increase weekly by 10 mg to max 60 mg/day in divided doses.

Children (6 to 12 yr of age)

PO 5 mg/day; may increase weekly by 5 mg to max 60 mg/day in divided doses.

Attention Deficit DisorderChildren 6 yr of age and older

PO 5 mg/day; may increase weekly by 5 mg to max 40 mg/day in divided doses. Usual range is 0.1 to 0.5 mg/kg/dose every morning.

Children 3 to 5 yr of age

PO 2.5 mg/day; may increase weekly by 2.5 mg. Usual range is 0.1 to 0.5 mg/kg/dose every morning.

Exogenous ObesityAdults 12 yr of age and older

PO 5 to 10 mg 30 to 60 min before meals, up to 30 mg/day. For long-acting form, 10 to 15 mg every morning.

General Advice

  • Do not crush or open sustained-release tablets.


Dispense in a tight, light-resistant container. Store at 15° to 30°C (59° to 86°F).

Drug Interactions


Amphetamines may decrease effectiveness.

MAOIs, furazolidone

Hypertensive crisis and intracranial hemorrhage may occur.

Tricyclic antidepressants

May decrease amphetamine effect.

Urinary acidifiers (eg, ammonium chloride, ascorbic acid)

May decrease amphetamine levels.

Urinary alkalinizers (eg, acetazolamide, sodium bicarbonate)

May increase amphetamine levels.

Laboratory Test Interactions

Plasma and urinary steroid levels may be altered.

Adverse Reactions


Palpitations; tachycardia; hypertension; arrhythmias.


Nervousness; tremors; dizziness; insomnia, euphoria; headache.




Dry mouth; unpleasant taste.


Diarrhea; constipation; anorexia.





Drug dependence may develop with chronic use. Avoid prolonged periods of use.

High abuse/diversion potential.

Prescribe/dispense sparingly because of high diversion potential.


Category C .


Excreted in breast milk.


Do not use as anorectic agent in children younger than 12 yr of age. Not recommended for attention-deficit disorder in children younger than 3 yr of age.

Tartrazine Sensitivity

Some products contain tartrazine, which may cause allergic reactions in susceptible individuals.


Tolerance may occur; do not exceed recommended dose to overcome this.



Restlessness, tremor, hyperreflexia, confusion, hallucinations, panic, fatigue, depression, convulsions, coma, arrhythmias, hypertension, hypotension, circulatory collapse, nausea, vomiting, diarrhea, abdominal cramps.

Patient Information

  • Instruct patient to take medication early in morning and, if possible, to take last dose at bedtime.
  • Tell patient to record body weight weekly.
  • Instruct patient/family to measure height monthly if patient is child.
  • Tell patient to limit intake of coffee, tea, cocoa, chocolate, and caffeinated soft drinks.
  • Explain importance of good oral hygiene to prevent or treat dry mouth and changes in breath odor.
  • Instruct patient to be aware of increased agitation, palpitations, and dizziness, and to take precautions while performing tasks that require physical coordination or mental alertness.

Copyright © 2009 Wolters Kluwer Health.

  • Dextroamphetamine Prescribing Information (FDA)
  • Dexedrine Detailed Consumer Information (PDR)
  • Dexedrine Prescribing Information (FDA)
  • Dexedrine MedFacts Consumer Leaflet (Wolters Kluwer)
  • Dexedrine Concise Consumer Information (Cerner Multum)
  • Dexedrine Advanced Consumer (Micromedex) - Includes Dosage Information
  • Dexedrine Spansule Sustained-Release Capsules MedFacts Consumer Leaflet (Wolters Kluwer)
  • Dextrostat Prescribing Information (FDA)
  • Liquadd Solution MedFacts Consumer Leaflet (Wolters Kluwer)

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