Generic Name: glyburide (GLYE bue ride)Brand Names: DiaBeta, Glynase PresTab, Micronase
Glyburide is an oral diabetes medicine that help control blood sugar levels.
Glyburide is used to treat type 2 diabetes (non-insulin dependent).
This medication is not for treating type 1 diabetes.
Glyburide may also be used for other purposes not listed in this medication guide.
Before taking glyburide, tell your doctor if you are allergic to sulfa drugs, if you have been using insulin or chlorpropamide (Diabinese), or if you have hemolytic anemia (a lack of red blood cells), an enzyme deficiency G6PD, a nerve disorder, liver disease, or kidney disease.Know the signs of low blood sugar (hypoglycemia) and how to recognize them. Always keep a source of sugar available in case you have symptoms of low blood sugar.What should I discuss with my health care provider before taking DiaBeta (glyburide)?You should not use this medication if you are allergic to glyburide, or:
if you are being treated with bosentan (Tracleer);
if you have type 1 (insulin-dependent) diabetes; or
if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).
If you have any of these other conditions, you may need a dose adjustment or special tests to safely take glyburide:
hemolytic anemia (a lack of red blood cells);
an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
a nerve disorder affecting bodily functions;
if you are allergic to sulfa drugs; or
if you have been using insulin or taking chlorpropamide (Diabinese).
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results from this medication.
Take glyburide with your first meal of the day, unless your doctor tells you otherwise.
Your blood sugar will need to be checked on a regular basis. You may also need other blood tests at your doctor's office. Do not miss any appointments.
Your dose needs may change if you become ill, have a fever or infection, or if you have surgery or a medical emergency. Your doctor may want you to stop taking glyburide for a short time if any of these situations affect you.
Take care not to let your blood sugar get too low, causing hypoglycemia. You may have hypoglycemia if you skip a meal, exercise too long, drink alcohol, or are under stress.Know the signs of low blood sugar (hypoglycemia) and how to recognize them: hunger, headache, confusion, irritability, drowsiness, weakness, dizziness, tremors, sweating, fast heartbeat, seizure, or fainting (severe hypoglycemia can be fatal).
Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection.If your blood sugar gets too high (hyperglycemia), you may feel very thirsty or hungry. You may also urinate more than usual. Call your doctor right away if you have any symptoms of hyperglycemia.
If there are any changes in the brand, strength, or type of glyburide you use, your dosage needs may change. Always check your refills to make sure you have received the correct brand and type of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.
Glyburide is only part of a complete program of treatment that also includes diet, exercise, and weight control. It is important to use this medicine regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.Store glyburide at room temperature, protected from moisture, heat, and light.
See also: DiaBeta dosage in more detail
Take the missed dose as soon as you remember (be sure to take the medicine with food). If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
pale skin, confusion or weakness;
easy bruising or bleeding, purple or red pinpoint spots under your skin; or
headache, trouble concentrating, memory problems, feeling unsteady, hallucinations, fainting, seizure, shallow breathing or breathing that stops.
Less serious side effects may include:
mild nausea, heartburn, feeling full;
joint or muscle pain;
blurred vision; or
mild itching or skin rash.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Tell your doctor about all other medications you use, especially:
a blood thinner such as warfarin (Coumadin);
cyclosporine (Gengraf, Neoral, Sandimmune);
fluconazole (Diflucan), ketoconazole (Nizoral); or
rifampin (Rifadin, Rimactane, Rifater);
an ACE inhibitor such as enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others; or
an antibiotic such as ciprofloxacin (Cipro), levofloxacin (Levaquin), and others.
Using certain medicines can make it harder for you to tell when you have low blood sugar. Tell your doctor if you use any of the following:
albuterol (Proventil, Ventolin);
guanethidine (Ismelin); or
beta-blockers such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others.
You may be more likely to have hyperglycemia (high blood sugar) if you are taking glyburide with other drugs that raise blood sugar, such as:
diuretics (water pills);
steroids (prednisone and others);
phenothiazines (Compazine and others);
thyroid medicine (Synthroid and others);
birth control pills and other hormones;
heart or blood pressure medications (Cartia, Cardizem, Nifedical, Covera, Verelan, and others);
seizure medicines (Dilantin and others); and
diet pills or medicines to treat asthma, colds or allergies.
You may be more likely to have hypoglycemia (low blood sugar) if you are taking glyburide with other drugs that lower blood sugar, such as:
some nonsteroidal anti-inflammatory drugs (NSAIDs);
aspirin or other salicylates (including Pepto-Bismol);
sulfa drugs (Bactrim, Gantanol, Septra, and others); and
a monoamine oxidase inhibitor (MAOI).
This list is not complete and there may be other drugs that can interact with glyburide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.