Trade Names:Dicloxacillin Sodium- Capsules 250 mg- Capsules 500 mg
Inhibits bacterial cell wall mucopeptide synthesis.
Rapid and incomplete absorption. T max is 1 to 1.5 h. C max is 10 to 17 mcg/mL. Food delays absorption; take on empty stomach.
Approximately 98% protein bound, mainly to albumin. Excreted in breast milk and crosses the placenta. Low CSF penetration.
Rapidly eliminated, primarily as unchanged drug in the urine. Nonrenal elimination includes hepatic inactivation and excretion in bile. t ½ approximately 0.7 h.
Treatment of infections caused by penicillinase-producing staphylococcal infection; initial therapy of suspected staphylococcal infection.
Hypersensitivity to penicillins.
PO 125 to 250 mg every 6 h.Children weighing less than 40 kg
PO 12.5 to 25 mg/kg/day divided in equal doses every 6 h.
May reduce efficacy of oral contraceptives.Food
Antibacterial action may be reduced.Tetracyclines
May impair bactericidal effects of dicloxacillin.
May cause false-positive urine glucose test results with Benedict solution, Fehling solution, or Clinitest tablets but not with enzyme-based tests (eg, Clinistix , Tes-tape ); false-positive direct Coombs test results in certain patient groups; false-positive protein reactions with sulfosalicylic acid and boiling test, acetic acid test, biuret reaction and nitric acid test but not with bromphenol blue test ( Multistix ).
Dizziness; fatigue; insomnia; reversible hyperactivity; seizures.
Urticaria; dermatitis; vesicular eruptions; erythema multiforme; rashes.
Laryngospasm; laryngeal edema; itchy eyes.
Glossitis; stomatitis; gastritis; sore mouth or tongue; dry mouth; furry tongue; “black hairy” tongue; abnormal taste sensation; anorexia; nausea; vomiting; abdominal pain or cramps; diarrhea or bloody diarrhea; rectal bleeding; flatulence; enterocolitis; pseudomembranous colitis.
Interstitial nephritis (eg, oliguria, proteinuria, hematuria, hyaline casts, pyuria); nephropathy.
Anemias; thrombocytopenia; eosinophilia; leukopenia; granulocytopenia; neutropenia; bone marrow depression; agranulocytosis; reduced hemoglobin or hematocrit; prolonged bleeding and prothrombin time; altered lymphocyte count; increased monocytes, basophils, platelets.
Transient hepatitis; cholestatic jaundice.
Elevated serum alkaline phosphatase and hypernatremia; reduced serum potassium, albumin, total proteins and uric acid.
Hypersensitivity reactions that may lead to death; vaginitis; hyperthermia.
Category B .
Excreted in breast milk.
Reactions range from mild to life-threatening. Administer cautiously to cephalosporin-sensitive patients because of possible cross-reactivity.
May result in bacterial or fungal overgrowth of nonsusceptible organisms.
Consider possibility in patients with diarrhea.
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