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Drugs reference index «Didanosine Solution»

Didanosine Solution

Generic Name: Didanosine (dye-DAN-oh-seen)Brand Name: Videx

Didanosine Solution may cause serious and sometimes fatal inflammation of the pancreas (pancreatitis). This has occurred in patients who have just started taking Didanosine Solution and in patients who have already been taking it. Contact your doctor immediately if you experience sudden stomach or back pain, swelling of the stomach, fever or chills, nausea or vomiting, or fast heartbeat.

Didanosine Solution may cause severe and sometimes fatal lactic acidosis and liver problems. Fatal lactic acidosis has also occurred in pregnant women who have used Didanosine Solution along with certain other medicines for HIV (eg, stavudine). Tell your doctor if you are taking stavudine and you are pregnant or planning to become pregnant.

Didanosine Solution is used for:

Treating HIV infection when used in combination with other medicines.

Didanosine Solution is a nucleoside analogue reverse transcriptase inhibitor that stops the growth of HIV-1, the virus that causes AIDS.

Do NOT use Didanosine Solution if:

  • you are allergic to any ingredient in Didanosine Solution
  • you have pancreas problems (pancreatitis), an enlarged liver, abnormal liver function tests, or lactic acidosis
  • you are taking allopurinol, aluminum salts (eg, aluminum hydroxide), or ribavirin

Contact your doctor or health care provider right away if any of these apply to you.

Before using Didanosine Solution:

Some medical conditions may interact with Didanosine Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart problems (eg, heart attack)
  • if you have advanced HIV infection (AIDS), kidney problems, liver problems, gallstones, nerve problems (neuropathy), high blood cholesterol or lipid levels, or high blood amylase levels
  • if you are overweight or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Didanosine Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Allopurinol, ganciclovir, nucleotide reverse transcriptase inhibitors (eg, tenofovir), or ribavirin because they may increase the risk of Didanosine Solution's side effects
  • Aluminum salts (eg, aluminum hydroxide), anorexiants (eg, phentermine), or sympathomimetics (eg, albuterol, pseudoephedrine) because the risk of their side effects may be increased by Didanosine Solution
  • Azole antifungals (eg, itraconazole, ketoconazole), delavirdine, HIV protease inhibitors (eg, indinavir, lopinavir, nelfinavir), lithium, quinolones (eg, ciprofloxacin, levofloxacin), sulfones (eg, dapsone), or tetracyclines (eg, doxycycline) because their effectiveness may be decreased by Didanosine Solution
  • Hydroxyurea because the risk of pancreatitis may be increased
  • Methadone because it may decrease Didanosine Solution's effectiveness
  • Stavudine because the risk of pancreatitis or fatal lactic acidosis in pregnant women may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Didanosine Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Didanosine Solution:

Use Didanosine Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Didanosine Solution. Talk to your pharmacist if you have questions about this information.
  • Take Didanosine Solution by mouth on an empty stomach at least 1 hour before or 2 hours after eating.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • Didanosine Solution may reduce the effectiveness of certain other medicines when taken together. Ask your doctor or pharmacist if you should separate Didanosine Solution from any other medicines that you are taking.
  • Shake well before each use.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • Continue to take Didanosine Solution even if you feel well. Do not miss any doses.
  • If you miss a dose of Didanosine Solution, take it as soon as you remember. If it is within 2 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. It is important not to miss doses of Didanosine Solution. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Didanosine Solution.

Important safety information:

  • Do not drink alcohol while you are taking Didanosine Solution.
  • Didanosine Solution is not a cure for HIV infection. Patients may still get illnesses and infections associated with HIV. Remain under the care of your doctor.
  • Didanosine Solution does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control (eg, condoms) if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors.
  • When your medicine supply is low, get more from your doctor or pharmacist as soon as you can. Do not stop taking Didanosine Solution, even for a short period of time. If you do, the virus may grow resistant to the medicine and become harder to treat.
  • Changes in body fat may occur in some patients taking this type of medicine. These changes may include increased amount of fat in the upper back and neck, breast, and around the trunk, and loss of fat from the legs, arms, and face. The cause and long-term effects are unknown. Discuss any concerns with your doctor.
  • Lab tests, including periodic eye exams, may be performed while you use Didanosine Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Didanosine Solution with caution in the ELDERLY; they may be more sensitive to its effects.
  • Didanosine Solution should be used with extreme caution in CHILDREN younger than 2 weeks old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Didanosine Solution while you are pregnant. It is not known if Didanosine Solution is found in breast milk. Mothers infected with HIV should not breast-feed. There is a risk of passing the HIV infection or Didanosine Solution to the baby.

Possible side effects of Didanosine Solution:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast enlargement; changes in body fat; darkened complexion with purple markings; diarrhea; dry mouth; headache; itching; muscle pain; skin and facial wasting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; chest pain or discomfort, numbness of an arm or leg, or shortness of breath; confusion; dark urine; dizziness; fainting; fast, shallow breathing; fast, slow, or irregular heartbeat; fever or chills; lightheadedness; low body temperature; nausea or vomiting; numbness, tingling, or pain in hands or feet; seizures; severe muscle pain or cramping; stomach pain; tiredness; weakness; yellowing of skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include dark urine; diarrhea; pale stools; severe stomach pain with nausea and vomiting; tingling, burning, or numbness in hands or feet; unusual fatigue; yellowing of skin or eyes.

Proper storage of Didanosine Solution:

Store Didanosine Solution in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C), in a tightly closed container. Store away from heat and light. Do not keep longer than 30 days. Keep Didanosine Solution out of the reach of children and away from pets.

General information:

  • If you have any questions about Didanosine Solution, please talk with your doctor, pharmacist, or other health care provider.
  • Didanosine Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Didanosine Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Didanosine Prescribing Information (FDA)
  • Didanosine Detailed Consumer Information (PDR)
  • Didanosine Professional Patient Advice (Wolters Kluwer)
  • didanosine Advanced Consumer (Micromedex) - Includes Dosage Information
  • didanosine Concise Consumer Information (Cerner Multum)
  • Videx Prescribing Information (FDA)
  • Videx EC Prescribing Information (FDA)

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