Generic Name: diethylpropion (dye eth ill PROE pee on)Brand Names: Tenuate, Tenuate Dospan
Diethylpropion is a sympathomimetic amine, which is similar to an amphetamine. It is also known as an "anorectic" or an "anorexigenic" drug. Diethylpropion stimulates the central nervous system (nerves and brain), which increases your heart rate and blood pressure and decreases your appetite.
Diethylpropion is used as a short-term supplement to diet and exercise in the treatment of obesity.
Diethylpropion may also be used for purposes other than those listed in this medication guide.
have heart disease or high blood pressure;
have arteriosclerosis (hardening of the arteries);
have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days; or
have a history of drug or alcohol abuse.
Before taking this medication, tell your doctor if you have
problems with your thyroid,
an anxiety disorder,
epilepsy or another seizure disorder, or
You may not be able to take diethylpropion, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.Diethylpropion is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take diethylpropion without first talking to your doctor if you are pregnant. Diethylpropion passes into breast milk and may affect a nursing baby. Do not take diethylpropion without first talking to your doctor if you are breast-feeding a baby.
Take diethylpropion exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.Take each dose with a full glass of water. Take diethylpropion on an empty stomach 1 hour before meals. An evening dose may be taken to overcome nighttime hunger.
Diethylpropion is usually taken three times a day (regular-release formula). Follow your doctor's instructions.
The sustained-release formulation is usually taken once a day in the midmorning.Do not crush, chew or open any "once-daily" (long-acting or sustained-release) diethylpropion tablets or capsules. Swallow them whole. Never take more of this medication than is prescribed for you. Too much diethylpropion could be very dangerous to your health. Store diethylpropion at room temperature away from moisture and heat.
See also: Diethylpropion dosage in more detail
Symptoms of a diethylpropion overdose include restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures.
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
an irregular heartbeat or very high blood pressure (severe headache, blurred vision); or
hallucinations, abnormal behavior, or confusion.
Other, less serious side effects may be more likely to occur. Continue to take diethylpropion and talk to your doctor if you experience
restlessness or tremor,
nervousness or anxiety,
headache or dizziness,
dry mouth or an unpleasant taste in your mouth,
diarrhea or constipation, or
impotence or changes in your sex drive.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Obesity:
For short-term use in the management of exogenous obesity:Immediate release tablets: 25 mg 3 times a day, 1 hour before meals, and in midevening if needed to cover overnight hunger.Controlled release tablets: 75 mg once a day, swallowed whole, in the morning.
You cannot take diethylpropion if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days.
Changes in insulin and other diabetes drug therapies may be necessary during treatment with diethylpropion.
Diethylpropion may reduce the effects of guanethidine (Ismelin). This could lead to an increase in blood pressure. Tell your doctor if you are taking guanethidine.
Before taking this medication, tell your doctor if you are taking a tricyclic antidepressant such as amitriptyline (Elavil), amoxapine (Asendin), doxepin (Sinequan), nortriptyline (Pamelor), imipramine (Tofranil), clomipramine (Anafranil), protriptyline (Vivactil), or desipramine (Norpramin). These drugs may decrease the effects of diethylpropion.
Drugs other than those listed here may also interact with diethylpropion. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.