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Drugs reference index «Diflunisal»

Diflunisal

Brand names: Dolobid

Why is Diflunisal prescribed?

Dolobid, a nonsteroidal anti-inflammatory drug, is used to treat mild to moderate pain and relieve the inflammation, swelling, stiffness, and joint pain associated with rheumatoid arthritis and osteoarthritis (the most common form of arthritis).

Most important fact about Diflunisal

You should have frequent checkups with your doctor if you take Dolobid regularly. Ulcers or internal bleeding can occur without warning.

How should you take Diflunisal?

Dolobid should be taken with food or food together with an antacid, and with a full glass of water or milk. Never take it on an empty stomach.

Tablets should be swallowed whole, not chewed or crushed.

Take Diflunisal exactly as prescribed by your doctor. If you are using Dolobid for arthritis, it should be taken regularly.

  • If you miss a dose...Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.
  • Storage instructions...Do not store in damp places like the bathroom.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Dolobid.

  • Side effects may include:Abdominal pain, constipation, diarrhea, dizziness, fatigue, gas, headache, inability to sleep, indigestion, nausea, rash, ringing in ears, sleepiness, vomiting

Why should Diflunisal not be prescribed?

If you are sensitive to or have had an allergic reaction to Dolobid, aspirin, or similar drugs, or if you have had asthma attacks caused by aspirin or other drugs of this type, you should not take Diflunisal. Make sure that your doctor is aware of any drug reactions that you have experienced.

Special warnings about Diflunisal

Stomach ulcers and bleeding can occur without warning, especially if you are 65 or older. These and other side effects are also more likely if you have poor kidney function.

This drug should be used with caution if you have kidney or liver disease; and it can cause liver inflammation in some people.

Do not take aspirin or any other anti-inflammatory medications while taking Dolobid, unless your doctor tells you to do so.

Nonsteroidal anti-inflammatory drugs such as Dolobid can hide the signs and symptoms of infection. Be sure your doctor knows about any infection you may have.

Dolobid can cause vision problems. If you experience any changes in your vision, inform your doctor.

Dolobid may prolong bleeding time. If you are taking blood-thinning medication, take Dolobid with caution.

If you have heart disease or high blood pressure, use Dolobid with caution. It can increase water retention.

Dolobid may cause you to become drowsy or less alert; therefore, driving or operating dangerous machinery or participating in any hazardous activity that requires full mental alertness is not recommended.

Possible food and drug interactions when taking Diflunisal

If Dolobid is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Dolobid with the following:

AcetaminophenAnticoagulants such as warfarinAntacids taken regularlyAspirinCyclosporineMethotrexateOral anticoagulants (blood thinners)Other nonsteroidal anti-inflammatory drugsThe arthritis medication sulindacThe diuretic hydrochlorothiazide

Special information if you are pregnant or breastfeeding

The effects of taking Dolobid during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Dolobid appears in breast milk and could affect a nursing infant. If Diflunisal is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with Dolobid is finished.

Recommended dosage for Diflunisal

ADULTS

Mild to Moderate Pain

Starting dose is 1,000 milligrams, followed by 500 milligrams every 8 to 12 hours, depending on the individual. Your physician may adjust your dosage according to your age and weight, and the severity of your symptoms.

Osteoarthritis and Rheumatoid Arthritis

The usual dose is 500 to 1,000 milligrams per day in 2 doses of 250 milligrams or 500 milligrams. Use no more than necessary to relieve the pain.

The maximum recommended dosage is 1,500 milligrams per day.

CHILDREN

Safety and effectiveness of Dolobid have not been established in children under 12 years of age. The drug is not recommended for this age group.

Overdosage

Any medication taken in excess can cause symptoms of overdose. If you suspect an overdose, seek medical attention immediately.

  • Symptoms of Dolobid overdose may include:Abnormally rapid heartbeat, coma, diarrhea, disorientation, drowsiness, hyperventilation, nausea, ringing in the ears, stupor, sweating, vomiting
  • Diflunisal MedFacts Consumer Leaflet (Wolters Kluwer)
  • Diflunisal Prescribing Information (FDA)
  • Diflunisal Professional Patient Advice (Wolters Kluwer)
  • diflunisal Concise Consumer Information (Cerner Multum)
  • diflunisal Advanced Consumer (Micromedex) - Includes Dosage Information

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