Trade Names:Dolobid- Tablets 500 mgApo-Diflunisal (Canada)
Decreases inflammation and relieves pain by inhibiting prostaglandin synthesis and release.
Rapidly and completely absorbed. T max is 2 to 3 h. C max is approximately 41 to 124 mcg/mL (250 to 1,000 mg single doses).
More than 99% protein bound.
Metabolized to glucuronide conjugates.
The t ½ is 8 to 12 h. Approximately 90% excreted in the urine as 2 soluble glucuronide conjugates.
2 to 3 h.
Relief of mild to moderate pain, rheumatoid arthritis, and osteoarthritis.
Treatment of perioperative pain in the setting of coronary artery bypass graft surgery; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; hypersensitivity to any component of the product.
PO 1,000 mg for first dose, then 500 mg every 8 to 12 h.Arthritis/OsteoarthritisAdults
PO 250 to 1,000 in 2 divided doses twice daily.
Store at 68° to 77°F.
Antihypertensive effect of ACE inhibitors may be reduced.Antacids
Decreased plasma concentration of diflunisal.Aspirin
Protein binding of diflunisal may be reduced; in addition, the risk of GI bleeding and ulcers may be increased.Cyclosporine
Increased nephrotoxic effect of cyclosporine possible.Diuretics (eg, furosemide, thiazides [eg, hydrochlorothiazide])
Natriuretic effect of diuretic may be reduced.Lithium
Serum levels may be elevated by diflunisal, increasing the risk of lithium toxicity.NSAIDs
Coadministration not recommended.Methotrexate
Life-threatening methotrexate toxicity possible.Warfarin
Prothrombin time may increase; increased risk of bleeding.
May falsely elevate salicylate serum concentrations.
Headache (3% to 9%); dizziness, fatigue/tiredness, insomnia, somnolence (greater than 1%).
Rash (3% to 9%).
Tinnitus (greater than 1%).
Diarrhea, dyspepsia, GI pain, nausea (3% to 9%); constipation, flatulence, vomiting (greater than 1%).
NSAIDs may cause an increased risk of serious CV thrombotic events, MI, and stroke, which can be fatal. This risk may increase with length of therapy. Patients with CV disease or risk factors for CV disease may be at greater risk. NSAIDs cause an increased risk of serious GI adverse reactions, including inflammation, bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur any time during use or without warning symptoms. Elderly patients are at greater risk of serious GI events.
Monitor for signs or symptoms of GI bleeding; patients on long-term therapy should have CBC, blood chemistry, and LFTs checked periodically. Perform eye exams if patient experiences visual disturbances. Monitor BP closely during initiation of therapy and throughout course of therapy.
Category C . Avoid late in pregnancy.
Excreted in breast milk.
Not recommended for children younger than 12 yr of age.
Use with caution.
Not recommended in advanced renal disease.
Borderline elevations of 1 or more LFTs may occur.
Do not administer to patients with aspirin triad, which typically occurs in patients with asthma who experience rhinitis with or without nasal polyps, or patients who exhibit severe, potentially fatal bronchospasm after taking aspirin or other NSAIDs.
Use with caution in patents with preexisting asthma.
Fluid retention and edema may occur; use with caution in patients with fluid retention or heart failure.
Use carefully and closely monitor for GI bleeding or peptic ulcer.
Anemia may occur.
Diflunisal can lead to onset of new hypertension or worsening of preexisting hypertension, which may contribute to an increased incidence of CV events.
Renal papillary necrosis and other renal injury can occur with long-term administration.
May increase risk of Reye syndrome; do not use if varicella infection or flu symptoms are suspected.
Serious, life-threatening adverse skin reactions, including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, may occur.
Cardiorespiratory arrest, decreased urine output, diarrhea, disorientation, drowsiness, hyperventilation, nausea, stupor and coma, sweating, tachycardia, tinnitus, vomiting. Overdose may lead to death.
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