Trade Names:Children's Dramamine- Liquid 12.5 mg/5 mL
Trade Names:Dimetabs- Tablets 50 mg
Trade Names:Dinate- Injection 50 mg/mL
Trade Names:Dramamine- Liquid 15.62 mg/5 mL- Liquid 12.5 mg/4 mL- Tablets 50 mg- Tablets, chewable 50 mg
Trade Names:Dramanate- Injection 50 mg/mL
Trade Names:Dymenate- Injection 50 mg/mL
Trade Names:Triptone- Tablets 50 mg/mLApo-Dimenhydrinate (Canada)Gravol (Canada)
Directly inhibits labyrinthine stimulation for up to 3 h.
Small amounts excreted in breast milk.
20 to 30 min (IM).
3 to 6 h.
Prevention and treatment of motion sickness, dizziness, nausea, vomiting.
Treatment of Meniere disease, nausea and vomiting of pregnancy, postoperative nausea, and vomiting.
Use in newborns; allergic reactions to diphenhydramine.
PO 50 to 100 mg 30 min prior to travel, followed by 50 to 100 mg every 4 to 6 h (max 400 mg/day). IM 50 mg as needed. IV 50 mg in 10 mL of sodium chloride for injection administered over 2 min.Children (6 to 12 yr of age)
PO 25 to 50 mg every 6 to 8 h (max 150 mg/day). IM 1.25 mg/kg 4 times daily (max 300 mg/day).Children (2 to 6 yr of age)
PO Up to 12.5 to 25 mg every 6 to 8 h (max 75 mg/day). IM 1.25 mg/kg 4 times daily (max 300 mg/day).
Enhances CNS depressant effects.Aminoglycosides
May mask signs of aminoglycoside-related ototoxicity.Anticholinergic drugs
Causes additive anticholinergic effects.
Ammonium chloride, amobarbital, butorphanol, chlorpromazine, glycopyrrolate, heparin, hydrocortisone, hydroxyzine, midazolam, pentobarbital, phenobarbital, phenytoin, prednisolone, prochlorperazine, promethazine, tetracycline, theophylline, thiopental, trifluoperazine.
May cause false elevation in serum theophylline levels.
Palpitations; hypotension; tachycardia.
Sedation; hallucinations; delirium; drowsiness; confusion, nervousness; restlessness; headache; insomnia; tingling, heaviness and weakness of hands; vertigo; dizziness; lassitude; excitation.
Fixed drug eruption; photosensitivity.
Diminished night vision; decreased color discrimination; exacerbation of narrow-angle glaucoma; blurred vision; diplopia; nasal stuffiness; dryness of nose and throat.
Nausea; vomiting; diarrhea; GI distress; constipation; anorexia; dry mouth.
Prostatic enlargement; difficult or painful urination.
Tightness of chest; wheezing; thickening of bronchial secretions.
Take safety precautions if drowsiness or dizziness occurs. Note paradoxical effect occurs (eg, insomnia, CNS stimulation), and visual or auditory disturbances (eg, blurred vision/tinnitus, hearing loss).
Category B .
Excreted in breast milk.
Safety and efficacy in children younger than 2 yr of age not established.
Previous reactions to diphenhydramine.
Use caution in patients with asthma, prostatic hypertrophy, narrow-angle glaucoma, stenosing peptic ulcer, cardiac arrhythmias.
Drowsiness, hallucinations, convulsions, coma, respiratory depression.
Copyright © 2009 Wolters Kluwer Health.