Trade Names:Logen- Tablets 2.5 mg diphenoxylate hydrochloride and 0.025 mg atropine sulfate
Trade Names:Lomanate- Liquid 2.5 mg diphenoxylate hydrochloride and 0.025 mg atropine sulfate per 5 mL
Trade Names:Lomotil- Liquid 2.5 mg diphenoxylate hydrochloride and 0.025 mg atropine sulfate per 5 mL- Tablets 2.5 mg diphenoxylate hydrochloride and 0.025 mg atropine sulfate
Trade Names:Lonox- Tablets 2.5 mg diphenoxylate hydrochloride and 0.025 mg atropine sulfate
Diphenoxylate, related to meperidine, decreases motility of GI tract. Atropine discourages deliberate overdosage of diphenoxylate.
Adjunctive therapy in treatment of diarrhea.
Obstructive jaundice; diarrhea associated with pseudomembranous enterocolitis or enterotoxin-producing bacteria; narrow-angle glaucoma; use in children younger than 2 yr of age.
Tablets may be crushed and administered with fluid.Adults
Initial dose: PO 5 mg 4 times daily. Individualize dose.Children 2 to 12 yr of age
PO 0.3 to 0.4 mg/kg/day in 4 divided doses.
Store in tightly closed, light-resistant container at room temperature.
May increase depressant actionMAOIs
May precipitate hypertensive crisis.
None well documented.
Dizziness; drowsiness; sedation; headache; malaise; lethargy; restlessness; euphoria; depression; numbness of extremities; confusion.
Pruritus; angioneurotic edema; urticaria; dry skin and mucous membranes; flushing.
Dry mouth; anorexia; nausea; vomiting; abdominal discomfort; paralytic ileus; toxic megacolon; pancreatitis; constipation.
Swelling of gums; anaphylaxis; hyperthermia.
Assess frequency and consistency of stools before and throughout therapy. Monitor for signs of dehydration and toxic megacolon.
Category B .
Excreted in breast milk.
Contraindicated in children younger than 2 yr of age. Greater risk of atropinism, especially with Down syndrome.
Use with extreme caution; may precipitate hepatic coma.
Do not give for diarrhea associated with organisms that penetrate the intestinal mucosa (ie, Salmonella , Shigella ), acute Crohn disease or pseudomembranous colitis caused by antibiotic therapy. Notify health care provider and discontinue therapy for abdominal distention or other untoward symptoms.
Dehydration may contribute to adverse effects, especially in young children. If dehydration or electrolyte imbalance occurs, may need to discontinue therapy until condition is corrected.
Dry skin and mucous membranes, mydriasis, restlessness, flushing, hyperthermia, tachycardia, lethargy, coma, nystagmus, pinpoint pupils, respiratory depression.
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