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Drugs reference index «Dipivefrin hydrochloride»

Dipivefrin hydrochloride

Brand names: Propine

Why is Dipivefrin hydrochloride prescribed?

Propine is used to treat chronic open-angle glaucoma, the most common form of the disease. In glaucoma, the fluid inside the eyeball is under abnormally high pressure, a condition which can cause vision problems or even blindness.

Propine belongs to a class of medication called prodrugs—drugs that generally are not active by themselves, but are converted in the body to an active form. This makes for better absorption, stability, and comfort and reduces side effects.

Most important fact about Dipivefrin hydrochloride

There is no cure for glaucoma. Propine and similar drugs can keep ocular pressure under control, but only as long as you take them. You will probably need to continue treatment for life; and you must be sure to take the medication regularly.

How should you take Dipivefrin hydrochloride?

Use Dipivefrin hydrochloride exactly as prescribed. If you use too much, or use it too often, Propine may cause side effects.

Wash your hands before and after you use the eyedrops. Once the drops are in your eye, keep your eye closed for 1 to 2 minutes, applying pressure to the inside corner of your eye, so the medicine can be properly absorbed.

To keep the medication free of contamination, do not touch the applicator tip to your eye or any other surface.

A number appears on the cap of the dropper bottle to tell you what dose you are taking. When you are ready to take the first dose, make sure the number 1 appears in the window. After each dose, replace the cap and rotate it to the next number. Turn until you hear a click.

  • If you miss a dose...Apply it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never apply more than 1 dose at a time.
  • Storage instructions...Keep Propine in the plastic dropper bottle it came in.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Propine.

  • Side effects may include:Burning and stinging, red eye

Why should Dipivefrin hydrochloride not be prescribed?

If you are sensitive to or have ever had an allergic reaction to Propine or any of its ingredients, you should not use Dipivefrin hydrochloride. Make sure your doctor is aware of any drug reactions you have experienced.

Unless you are directed to do so by your doctor, do not use Dipivefrin hydrochloride if you have narrow-angle glaucoma.

Special warnings about Dipivefrin hydrochloride

Propine may cause vision problems, including blurry vision, for a short time after the eyedrops are applied. If this occurs, make sure you do not drive, use machinery, or participate in any hazardous activity that requires clear vision.

Possible food and drug interactions when taking Dipivefrin hydrochloride

No significant interactions have been reported.

Special information if you are pregnant or breastfeeding

The effects of Propine during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Propine may appear in breast milk and could affect a nursing infant. If Dipivefrin hydrochloride is essential to your health, your doctor may advise you to discontinue breastfeeding your baby until your treatment is finished.

Recommended dosage for Dipivefrin hydrochloride


The usual dose is 1 drop in the eye(s) every 12 hours. It usually takes about 30 minutes for Propine to start working. You should feel the maximum effects of the drug within 1 hour.


The safety and effectiveness of Propine have not been established in children.


Any medication taken in excess can have serious consequences. If you suspect an overdose of Propine, seek medical attention immediately.

  • dipivefrin ophthalmic Concise Consumer Information (Cerner Multum)
  • Propine Prescribing Information (FDA)
  • Propine Advanced Consumer (Micromedex) - Includes Dosage Information
  • Propine MedFacts Consumer Leaflet (Wolters Kluwer)

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