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Drugs reference index «dofetilide»

dofetilide (Oral route)

doe-FET-i-lide

Oral routeCapsule

To minimize the risk of induced arrhythmia, patients initiated or re-initiated on dofetilide should be placed for a minimum of 3 days in a facility that can provide calculations of creatinine clearance, continuous electrocardiographic monitoring, and cardiac resuscitation. Dofetilide is available only to hospitals and prescribers who have received appropriate dofetilide dosing and treatment initiation education .

To minimize the risk of induced arrhythmia, patients initiated or re-initiated on dofetilide should be placed for a minimum of 3 days in a facility that can provide calculations of creatinine clearance, continuous ECG monitoring, and cardiac resuscitation. Dofetilide is available only to hospitals and prescribers who have received appropriate dofetilide dosing and treatment initiation education .

Commonly used brand name(s):

In the U.S.

  • Tikosyn

Available Dosage Forms:

  • Capsule

Therapeutic Class: Antiarrhythmic, Group III

Chemical Class: Methanesulfonanilide

Uses For dofetilide

Dofetilide belongs to the group of medicines known as antiarrhythmics. It is used to correct irregular heartbeats to a normal rhythm

Dofetilide produces its helpful effects by slowing nerve impulses in the heart.

dofetilide is available only with your doctor's prescription.

Before Using dofetilide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dofetilide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to dofetilide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on dofetilide have been done only in adult patients, and there is no specific information comparing use of dofetilide in children less than 18 years of age with use in other age groups.

Geriatric

dofetilide has been tested in patients 65 to 89 years old and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using dofetilide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Cimetidine
  • Cisapride
  • Dronedarone
  • Hydrochlorothiazide
  • Itraconazole
  • Ketoconazole
  • Levomethadyl
  • Megestrol
  • Mesoridazine
  • Pimozide
  • Prochlorperazine
  • Sparfloxacin
  • Sulfamethoxazole
  • Terfenadine
  • Thioridazine
  • Trimethoprim
  • Verapamil
  • Ziprasidone

Using dofetilide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Ajmaline
  • Amiloride
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amoxapine
  • Aprindine
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Azosemide
  • Bemetizide
  • Bendroflumethiazide
  • Benzthiazide
  • Bretylium
  • Bumetanide
  • Buthiazide
  • Chloral Hydrate
  • Chloroquine
  • Chlorothiazide
  • Chlorpromazine
  • Chlorthalidone
  • Ciprofloxacin
  • Clarithromycin
  • Clopamide
  • Cyclopenthiazide
  • Cyclothiazide
  • Desipramine
  • Diazoxide
  • Dibenzepin
  • Dirithromycin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Doxepin
  • Droperidol
  • Enflurane
  • Erythromycin
  • Ethacrynic Acid
  • Etozolin
  • Fenquizone
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Foscarnet
  • Furosemide
  • Gatifloxacin
  • Gemifloxacin
  • Halofantrine
  • Haloperidol
  • Halothane
  • Hydroflumethiazide
  • Hydroquinidine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Indapamide
  • Isoflurane
  • Isradipine
  • Josamycin
  • Lapatinib
  • Levofloxacin
  • Lidocaine
  • Lidoflazine
  • Lorcainide
  • Lumefantrine
  • Mefloquine
  • Metformin
  • Methadone
  • Methyclothiazide
  • Metolazone
  • Moxifloxacin
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Paliperidone
  • Pazopanib
  • Pentamidine
  • Piretanide
  • Pirmenol
  • Polythiazide
  • Prajmaline
  • Prilocaine
  • Probucol
  • Procainamide
  • Propafenone
  • Quetiapine
  • Quinethazone
  • Quinidine
  • Ranolazine
  • Risperidone
  • Roxithromycin
  • Sematilide
  • Sertindole
  • Sotalol
  • Spiramycin
  • Sultopride
  • Sunitinib
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Torsemide
  • Triamterene
  • Trichlormethiazide
  • Trimipramine
  • Troleandomycin
  • Vardenafil
  • Vasopressin
  • Voriconazole
  • Xipamide
  • Zolmitriptan
  • Zotepine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of dofetilide. Make sure you tell your doctor if you have any other medical problems, especially:

  • Electrolyte disorders, such as low potassium or magnesium levels or
  • Heart rhythm problems—may cause irregular heartbeats
  • Liver disease (severe)—Safety in this condition is unknown
  • Kidney disease—Higher blood levels may occur, which may increase the chance of side effects. Your doctor may need to change your dose.

Proper Use of dofetilide

Patient information about dofetilide is available. Read this information carefully.

Use dofetilide exactly as directed by your doctor . Do not use more or less of it, and do not use it more often than your doctor ordered. dofetilide works best when there is a constant amount in the body. To help keep the amount constant, it is best to take the doses at the same time every day.

Dosing

The dose of dofetilide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of dofetilide. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For abnormal heart rhythm:
      • Adults—125 to 500 micrograms (mcg) two times a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of dofetilide, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using dofetilide

It is very important that your doctor check your progress at regular visits to make sure that dofetilide is working properly and to check for unwanted effects. This will allow for changes to be made in the amount of medicine you are taking, if necessary.

Other medicines: Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines, such as Tagamet and Tagamet HB.

dofetilide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

More common
  • dizziness
  • fainting
  • fast or irregular heartbeat
Less common
  • Chest pain
  • confusion
  • facial or flaccid paralysis
  • numbness or tingling of the hands, feet or face
  • paralysis
  • pounding, slow heartbeat
  • slurred speech
  • swelling of the ankles, arms, face, feet, fingers, legs, lips, tongue, and/or throat
  • troubled breathing
  • unexplained shortness of breath
  • unusual tiredness or weakness
  • weight gain
  • yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Abdominal or stomach pain
  • accidental injury
  • back pain
  • chills
  • cough
  • diarrhea
  • fever
  • flu-like symptoms
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • migraine
  • muscle aches and pains
  • nausea
  • rash
  • runny nose
  • shivering
  • sneezing
  • sore throat
  • sweating
  • trouble sleeping
  • vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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  • dofetilide Concise Consumer Information (Cerner Multum)
  • Dofetilide MedFacts Consumer Leaflet (Wolters Kluwer)
  • Dofetilide Professional Patient Advice (Wolters Kluwer)
  • Tikosyn Prescribing Information (FDA)

See Also...

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