Trade Names:Tikosyn- Capsules 125 mcg- Capsules 250 mcg- Capsules 500 mcg
Blockade of the cardiac ion channel carrying the rapid component of the delayed rectifier potassium currents.
Bioavailability greater than 90%. T max is 2 to 3 h.
60% to 70% protein bound. Vd is 3 L/kg.
Metabolized by N-delkylation and N-oxidation, and to a lesser extent by CYP3A4.
t ½ approximately 10 h. Approximately 80% excreted in urine of which approximately 80% is unchanged drug.
Cl is decreased and t ½ is prolonged. Dosage adjustment recommended.Gender
Women have approximately 12% to 18% lower Cl.
Maintenance of normal sinus rhythm (delay in time to recurrence of atrial fibrillation/atrial flutter [AF/AFl]) in patients with AF/AFl of more than 1 wk duration who have been converted to normal sinus rhythm; conversion of AF/AFl to normal sinus rhythm.
Hypersensitivity to drug; congenital or acquired long QT syndromes; baseline QT interval of QTc greater than 440 msec (500 msec in patients with ventricular conduction abnormalities); severe renal function impairment (Ccr less than 20 mL/min); concurrent use of cimetidine, ketoconazole, trimethoprim (alone or in combination with sulfamethoxazole), or verapamil; concomitant use of known inhibitors of renal cation transport (eg, megestrol, prochlorperazine).
PO The dose must be individualized according to calculated Ccr and QTc. Use the QT interval if the heart rate is less than 60 bpm. There are no data on use if the heart rate is less than 50 bpm. The usual recommended dose is 500 mcg twice daily, as modified by the dosing algorithm described in the manufacturer's prescribing information.
Store capsules at controlled room temperature. Protect from moisture.
Contraindicated.Drugs actively secreted by renal cationic secretion (eg, amiloride, metformin, triamterene), inhibitors of CYP3A4 isozymes (eg, amiodarone, azole antifungal agents, cannabinoids, diltiazem, grapefruit juice, macrolide antibiotics, nefazodone, norfloxacin, protease inhibitors, quinine, serotonin reuptake inhibitors, zafirlukast)
May increase dofetilide levels; use with caution.Class I (eg, quinidine) or Class III (eg, sotalol) antiarrhythmics
Withhold for at least 3 half-lives prior to dosing with dofetilide.Drugs that prolong the QT interval (eg, bepridil, cisapride, phenothiazines, tricyclic antidepressants, erythromycin)
Concurrent use not recommended.
None well documented.
Ventricular tachyarrhythmia; chest pain; torsades de pointes; AV block; bundle branch block; heart block; angioedema; bradycardia; cerebral ischemia; cerebrovascular accident; cardiac arrest; MI; syncope.
Headache; dizziness; insomnia; migraine.
Diarrhea; abdominal pain.
Respiratory tract infection; dyspnea.
Flu syndrome; back pain; edema; facial paralysis; paralysis; paresthesia; sudden death.
Administer in an equipped facility that can provide Ccr calculations, continuous ECG monitoring, and resuscitation for at least 3 days when therapy is initiated or restarted.Restricted distribution
Restrict distribution to facilities/prescribers who have received approved educational program.
Ensure that Ccr has been calculated and the QTc interval and serum potassium have been determined before initiating therapy and periodically (at least every 3 mo) during treatment. Determine QTc interval 2 to 3 h after first dose and note change from baseline QTc interval. Notify health care provider if it has increased more than 15% or is greater than 500 msec. Monitor ECG for arrhythmias and conduction changes.
Category C .
Safety and efficacy not established.
Select dose with caution, reflecting the greater frequency of decreased renal function.
Plasma concentrations of dofetilide may be increased; dosage must be adjusted based on Ccr.
Use with caution in patients with severe hepatic function impairment.
Should be within normal range prior to and during administration of drug.
Risk may be reduced by controlling plasma concentrations of dofetilide by dosing according to Ccr and monitoring ECG.
Prolongation of the QT interval, ventricular fibrillation, cardiac arrest.
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