Generic Name: doxercalciferol (dock sir kal SIH fer all)Brand Names: Hectorol
Doxercalciferol is a synthetic (man-made) form of vitamin D. Vitamin D is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.
Doxercalciferol is used to reduce elevated intact parathyroid hormone (iPTH) levels in the treatment of secondary hyperparathyroidism in patients undergoing chronic renal dialysis.
Doxercalciferol may also be used for purposes other than those listed in this medication guide.
Contact your doctor if you experience weakness, headache, nausea and vomiting, dry mouth, constipation, a metallic taste in the mouth, increased thirst and/or urination, or decreased appetite. These can be early signs of too much calcium in the body.Do not take antacids that contain magnesium while taking doxercalciferol, unless otherwise directed by your doctor.
Before taking this medication, tell your doctor if you have liver disease. You may not be able to take doxercalciferol, or you may require a dosage adjustment or special monitoring during treatment if you have liver disease.Doxercalciferol is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take doxercalciferol without first talking to your doctor if you are pregnant. It is also not known whether doxercalciferol passes into breast milk. However, it is believed that doxercalciferol could affect a nursing baby. Do not take doxercalciferol if you are breast-feeding a baby.
Take doxercalciferol exactly as directed by your doctor. If you do not understand the directions on your prescription bottle, ask your pharmacist, nurse, or doctor to explain them to you.Take each dose with water.
Doxercalciferol is usually taken three times a week during dialysis. Follow your doctor's instructions.Store doxercalciferol at room temperature away from moisture, light, and heat.
See also: Doxercalciferol dosage in more detail
Notify your doctor if you miss a dose of doxercalciferol.
Symptoms of a doxercalciferol overdose are not known but may include irregular heartbeats, abdominal pain, nausea, vomiting, dry mouth, decreased appetite, constipation, weakness, muscle pain, bone pain, tiredness, headache, and a metallic taste in the mouth.
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
an irregular heartbeat;
increased nighttime urination; or
Contact your doctor if you experience any of the following side effects:
nausea, vomiting, or decreased appetite;
a metallic taste;
muscle or bone pain;
increased thirst or urination;
shortness of breath; or
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Secondary Hyperparathyroidism:
Initial: For patient iPTH level > 400 pg/mL: 10 mcg orally or 4 mcg intravenously following dialysis three times a week.Maintenance:For patient iPTH level reduced < 50% and above 300 pg/mL:Increase maintenance dose by 2.5 mcg orally or 1 to 2 mcg intravenously at 8 week intervals as necessary to bring iPTH level below 300 pg/mL.For patient iPTH level 150 to 300 pg/mL: maintain current oral or intravenous dose.For patient iPTH level < 100 pg/mL: suspend oral or intravenous dose dosage for 1 week, then resume oral dosage at least 2.5 mcg lower or intravenous dosage at least 1 mcg lower than the last administered dose.The maximum recommended oral dosage is 20 mcg three times a week (60 mcg total weekly dose). Intravenous dosages higher than 18 mcg a week (total weekly dose) have not been studied.
Before taking this medication, tell your doctor if you are taking any of the following medicines:
antacids that contain magnesium;
digoxin (Lanoxin, Lanoxicaps);
a vitamin D supplement;
mineral oil; or
You may not be able to take doxercalciferol, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with doxercalciferol. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines.