Doxorubicin Generic Name:
Doxorubicin (dox-oh-ROO-bi-sin)Brand Name:
Doxorubicin is for intravenous (IV) use only. If Doxorubicin accidentally leaks into surrounding tissue, the skin or muscle may be severely damaged. Notify your doctor immediately if redness, pain, or swelling at or around the injection site occur. Doxorubicin may cause heart problems (eg, heart failure) or bone marrow suppression. Notify your doctor immediately if you develop an irregular heartbeat, trouble breathing, swelling of the hands or feet, easy bruising or bleeding, a dry cough, or signs of an infection (eg, fever, unusual tiredness, persistent sore throat). Heart problems may occur during therapy or sometimes months to years after receiving Doxorubicin . The risk of developing heart problems varies depending on your dose and condition. The risk may be increased if you have a history of radiation therapy or if you are using cyclophosphamide. Tell your doctor if you have liver problems because your dose will have to be decreased. Your doctor will closely monitor you while you are using Doxorubicin .
Doxorubicin is used for:
Treating various types of cancer.
Doxorubicin is an antineoplastic antibiotic. It works by killing cancer cells.
Do NOT use Doxorubicin if:
- you are allergic to any ingredient in Doxorubicin
- you have bone marrow depression
- you have decreased blood cell counts resulting from previous anticancer medicine or radiation treatment
- you have previously received treatment with other anticancer medicines (eg, daunorubicin, idarubicin, another anthracycline or anthracene)
Contact your doctor or health care provider right away if any of these apply to you.
Before using Doxorubicin :
Some medical conditions may interact with Doxorubicin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have heart or blood vessel disease or liver problems
- if you have had radiation therapy
Some MEDICINES MAY INTERACT with Doxorubicin . Tell your health care provider if you are taking any other medicines, especially any of the following:
- Barbiturates (eg, phenobarbital) or streptozocin because the effectiveness of Doxorubicin may be decreased
- Calcium channel blockers (eg, verapamil), cyclophosphamide, cyclosporine, or paclitaxel because side effects, such as heart problems, may be increased
- Other anticancer medicines (eg, daunorubicin, idarubicin, anthracyclines, anthracenes) because the risk of toxicity may be increased
- Anticoagulants (eg, warfarin) or trastuzumab because the actions and side effects of these medicines may be increased
- Carbamazepine, digoxin, hydantoins (eg, phenytoin), live vaccines, or valproic acid because the effectiveness may be decreased by Doxorubicin
This may not be a complete list of all interactions that may occur. Ask your health care provider if Doxorubicin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Doxorubicin :
Use Doxorubicin as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Doxorubicin is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Doxorubicin at home, carefully follow the injection procedures taught to you by your health care provider.
- If Doxorubicin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
- Drinking extra fluids while you are taking Doxorubicin is recommended. Check with your doctor for instructions.
- If Doxorubicin accidentally spills on your skin, wash it off immediately with soap and water.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
- If you miss a dose of Doxorubicin , contact your doctor immediately.
Ask your health care provider any questions you may have about how to use Doxorubicin .
Important safety information:
- Doxorubicin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
- Doxorubicin may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.
- Caregivers of children should take precautions (eg, wear latex gloves) to prevent contact with the patient's urine and other body fluids for at least 5 days after treatment.
- Avoid vaccinations with live virus vaccines (eg, measles, mumps, oral polio) while you are taking Doxorubicin . Vaccinations may be less effective.
- Doxorubicin may cause the urine to turn red. This is harmless and usually goes away 1 to 2 days after receiving a dose of Doxorubicin .
- LAB TESTS, including liver function, complete blood cell counts, and heart function, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
- Use Doxorubicin with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Doxorubicin has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Doxorubicin during pregnancy. Doxorubicin is excreted in breast milk. Do not breast-feed while taking Doxorubicin .
Possible side effects of Doxorubicin :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Diarrhea; hair loss; loss of appetite; nausea; red-colored urine 1 to 2 days after receiving Doxorubicin ; tiredness; vomiting; weakness.Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest or back pain; fainting; fast heartbeat; headache; loose or bloody stools; pain, redness, or swelling at the injection site; rectal bleeding or irritation; redness, pain, swelling, peeling, tingling, or blistering of the palms of the hands and the soles of the feet; serious infection (eg, fever, chills, cough, sore throat); shortness of breath; sores in the mouth or on the lips; sudden irregular heartbeat; sudden weight gain; swelling of the ankles; tightness in the chest and throat; unusual bruising or bleeding.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include inflammation of the mouth.Proper storage of Doxorubicin :
Doxorubicin is usually handled and stored by a health care provider. If you are using Doxorubicin at home, store Doxorubicin as directed by your pharmacist or health care provider. Keep Doxorubicin out of the reach of children and away from pets.
- If you have any questions about Doxorubicin , please talk with your doctor, pharmacist, or other health care provider.
- Doxorubicin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Doxorubicin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
- Doxorubicin Prescribing Information (FDA)
- doxorubicin Concise Consumer Information (Cerner Multum)
- doxorubicin Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information