Doxorubicin Liposomal Generic Name:
Doxorubicin Liposomal (DOX-oh-ROO-bi-sin)Brand Name:
Doxorubicin Liposomal is for intravenous (IV) use only. If Doxorubicin Liposomal accidentally leaks into surrounding tissue, the skin or muscle may be severely damaged. Notify your doctor immediately if redness, pain, or swelling at or around the injection site occur. Doxorubicin Liposomal may cause heart problems (eg, heart failure) or bone marrow suppression. Notify your doctor immediately if you develop an irregular heartbeat, trouble breathing, swelling of the hands or feet, easy bruising or bleeding, a dry cough, or signs of an infection (eg, fever, unusual tiredness, persistent sore throat). Heart problems may occur during therapy or sometimes months to years after receiving Doxorubicin Liposomal . The risk of developing heart problems varies depending on your dose and condition. The risk may be increased if you have a history of radiation therapy or if you are using cyclophosphamide. Tell your doctor if you have liver problems because your dose will have to be decreased. Your doctor will closely monitor you while you are using Doxorubicin Liposomal .
Doxorubicin Liposomal is used for:
Treating advanced ovarian cancer and AIDS-related Kaposi sarcoma in certain patients. It is also used with another medicine to treat a type of bone marrow cancer (multiple myeloma) in certain patients.
Doxorubicin Liposomal is an antineoplastic antibiotic. It works by killing cancer cells.
Do NOT use Doxorubicin Liposomal if:
- you are allergic to any ingredient in Doxorubicin Liposomal or to conventional doxorubicin
- you have bone marrow depression
- you are breast-feeding
Contact your doctor or health care provider right away if any of these apply to you.
Before using Doxorubicin Liposomal :
Some medical conditions may interact with Doxorubicin Liposomal . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have heart disease or liver problems
- if you have had radiation therapy
- if you have previously received treatment with other anticancer medicines (eg, daunorubicin, idarubicin, another anthracycline or anthracene)
Some MEDICINES MAY INTERACT with Doxorubicin Liposomal . Tell your health care provider if you are taking any other medicines, especially any of the following:
- Barbiturates (eg, phenobarbital) or streptozocin because they may decrease Doxorubicin Liposomal 's effectiveness
- Calcium channel blockers (eg, verapamil), cyclophosphamide, cyclosporine, or paclitaxel because the risk of side effects, such as heart problems, may be increased
- Anticoagulants (eg, warfarin) or trastuzumab because their actions and the risk of their side effects may be increased by Doxorubicin Liposomal
- Carbamazepine, digoxin, hydantoins (eg, phenytoin), live vaccines, or valproic acid because their effectiveness may be decreased by Doxorubicin Liposomal
This may not be a complete list of all interactions that may occur. Ask your health care provider if Doxorubicin Liposomal may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Doxorubicin Liposomal :
Use Doxorubicin Liposomal as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Doxorubicin Liposomal is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Doxorubicin Liposomal at home, a health care provider will teach you how to use it. Be sure you understand how to use Doxorubicin Liposomal . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Doxorubicin Liposomal if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Drinking extra fluids while you are taking Doxorubicin Liposomal is recommended. Check with your doctor for instructions.
- If Doxorubicin Liposomal accidentally spills on your skin, wash it off immediately with soap and water.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Doxorubicin Liposomal , contact your doctor right away.
Ask your health care provider any questions you may have about how to use Doxorubicin Liposomal .
Important safety information:
- Doxorubicin Liposomal may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
- Doxorubicin Liposomal may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- Do not receive a live vaccine (eg, measles, mumps) while you are taking Doxorubicin Liposomal . Talk with your doctor before you receive any vaccine.
- Doxorubicin Liposomal may cause the urine to turn red. This is harmless and usually goes away 1 to 2 days after receiving a dose of Doxorubicin Liposomal .
- Lab tests, including liver function, complete blood cell counts, and heart function, may be performed while you use Doxorubicin Liposomal . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Doxorubicin Liposomal should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Doxorubicin Liposomal has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Doxorubicin Liposomal while you are pregnant. Doxorubicin Liposomal is found in breast milk. Do not breast-feed while taking Doxorubicin Liposomal .
Possible side effects of Doxorubicin Liposomal :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Diarrhea; hair loss; loss of appetite; nausea; pain, redness, or swelling at the injection site; red-colored urine 1 to 2 days after receiving Doxorubicin Liposomal ; tiredness; vomiting; weakness.Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain; bleeding or bruising; chest pain; cough; dizziness; fainting; flushing; hand-foot syndrome (tingling, burning, redness, swelling, flaking, small blisters or small sores on the palms of hands or sores of feet); headache; irregular or fast heartbeat; loose or bloody stools; rectal bleeding or irritation; serious infection (fever, chills, persistent sore throat); shortness of breath; sores in the mouth or on the lips; sudden weight gain; swelling of the face or ankles; tightness in the chest and throat; unusual tiredness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include inflammation of the mouth.Proper storage of Doxorubicin Liposomal :
Doxorubicin Liposomal is usually handled and stored by a health care provider. If you are using Doxorubicin Liposomal at home, store Doxorubicin Liposomal as directed by your pharmacist or health care provider. Keep Doxorubicin Liposomal out of the reach of children and away from pets.
- If you have any questions about Doxorubicin Liposomal , please talk with your doctor, pharmacist, or other health care provider.
- Doxorubicin Liposomal is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Doxorubicin Liposomal . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
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