Generic Name: hydrochlorothiazide and spironolactone (HYE dro KLOR oh THY a zide and spir ON oh LAK tone)Brand Names: Aldactazide
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Spironolactone is a potassium-sparing diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.
The combination of hydrochlorothiazide and spironolactone is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. This medication also treats high blood pressure (hypertension).
Hydrochlorothiazide and spironolactone may also be used for other purposes not listed in this medication guide.What is the most important information I should know about Aldactazide (hydrochlorothiazide and spironolactone)?Do not use this medication if you have kidney disease, urination problems, or high levels of potassium in your blood. Do not use potassium supplements while you are taking hydrochlorothiazide and spironolactone.
Before using this medication, tell your doctor if you have heart or liver disease, diabetes, a breathing disorder, gout, lupus, an allergy to sulfa drugs, or a pancreas disorder. Tell your doctor if you use a steroid or another blood pressure medicine.Avoid drinking alcohol, which can increase some of the side effects of hydrochlorothiazide and spironolactone.
Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking hydrochlorothiazide and spironolactone.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.What should I discuss with my doctor before taking Aldactazide (hydrochlorothiazide and spironolactone)?Do not use this medication if you are allergic to hydrochlorothiazide or spironolactone, or if you have:
high potassium levels (hyperkalemia); or
if you are taking potassium supplements.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:
cirrhosis or other liver disease;
a breathing disorder;
an allergy to sulfa drugs;
a pancreas disorder; or
if you are using another blood pressure medication or a steroid.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.Take each dose with a full glass of water.
To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.
Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using a thiazide diuretic.
If you need to have any type of surgery, tell the surgeon ahead of time that you are taking hydrochlorothiazide and spironolactone. You may need to stop using the medicine for a short time.
If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.Store the tablets at room temperature away from heat, light, and moisture.
See also: Aldactazide dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
numbness or tingly feeling;
muscle pain or weakness;
slow, fast, or uneven heartbeat;
feeling drowsy, restless, or light-headed;
urinating less than usual or not at all;
tremors, confusion; or
nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
mild nausea or vomiting;
gas, stomach pain; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.What other drugs will affect Aldactazide (hydrochlorothiazide and spironolactone)?Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to light-headedness caused by hydrochlorothiazide and spironolactone. Tell your doctor if you regularly use any of these medicines, or any other blood pressure medications.
Before taking this medication, tell your doctor if you are using any of the following drugs:
steroids (prednisone and others);
a blood thinner such as warfarin (Coumadin);
insulin or diabetes medicine taken by mouth;
an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others; or
indomethacin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others.
This list is not complete and there may be other drugs that can interact with hydrochlorothiazide and spironolactone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.