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Drugs reference index «Aldactazide»



Generic name: Spironolactone, HydrochlorothiazideBrand names: Aldactazide

Why is Aldactazide prescribed?

Aldactazide is used in the treatment of high blood pressure and other conditions that require the elimination of excess fluid from the body. These conditions include congestive heart failure, cirrhosis of the liver, and kidney disease. Aldactazide combines two diuretic drugs that help your body produce and eliminate more urine. Spironolactone, one of the ingredients, helps to minimize the potassium loss that can be caused by the hydrochlorothiazide component.

Most important fact about Aldactazide

If you have high blood pressure, you must take Aldactazide regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Aldactazide; and you must continue taking it even if you are feeling well. Aldactazide does not cure high blood pressure; it merely keeps it under control.

How should you take Aldactazide?

Take Aldactazide exactly as prescribed. Stopping Aldactazide suddenly could cause your condition to worsen.

  • If you miss a dose...Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.
  • Storage instructions...Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Aldactazide.

  • Side effects may include:Abdominal cramps, breast development in males, change in potassium levels (leading to such symptoms as dry mouth, excessive thirst, weak or irregular heartbeat, and muscle pain or cramps), deepening of the voice, diarrhea, dizziness, dizziness on rising, drowsiness, excessive hairiness, fever, headache, hives, inflammation of blood vessels or lymph vessels, inflammation of the pancreas, irregular menstruation, kidney problems, lack of coordination, liver problems, loss of appetite, mental confusion, muscle spasms, nausea, postmenopausal bleeding, rash, red or purple spots on skin, restlessness, sensitivity to light, severe allergic reaction, sexual dysfunction, sluggishness, stomach bleeding, stomach inflammation, stomach ulcers, tingling or pins and needles, vertigo, vomiting, weakness, yellow eyes and skin, yellow vision

Why should Aldactazide not be prescribed?

Aldactazide should not be used if you have acute kidney disease or liver failure, have difficulty urinating or are unable to urinate, or have high potassium levels in your blood.

If you are sensitive to or have ever had an allergic reaction to spironolactone, hydrochlorothiazide, or similar drugs, or if you are sensitive to sulfa drugs, you should not take Aldactazide. Make sure your doctor is aware of any drug reactions you may have experienced.

Special warnings about Aldactazide

This medication should be used only if your doctor has determined that the precise amount of each ingredient in Aldactazide meets your specific needs.

Drugs such as the hydrochlorothiazide component of Aldactazide have been known to trigger gout and allergic reactions. They can also raise your blood sugar levels.

Potassium supplements (including salt substitutes) or diuretics that leave high levels of potassium in your body should not be used while taking Aldactazide, unless specifically recommended by your doctor. Symptoms of excess potassium include tingling sensations, fatigue, muscle weakness or paralysis, and a slow heartbeat. If you develop these problems, call your doctor immediately.

If you are taking an ACE-inhibitor type of blood pressure medication such as enalapril maleate, Aldactazide should be used with extreme caution.

If you have liver or kidney disease or lupus erythematosus (a disease that causes skin eruptions), Aldactazide should be used with caution.

Excessive sweating, severe diarrhea, or vomiting could cause you to lose too much water and cause your blood pressure to become too low. Signs of dehydration include thirst, dry mouth, weakness, drowsiness, muscle fatigue, muscle cramps, restlessness, reduced urination, and a rapid heartbeat. Be sure to drink plenty of fluids whenever dehydration threatens, and be careful when exercising in hot weather.

Notify your doctor or dentist that you are taking Aldactazide if you have a medical emergency, and before you have surgery or dental treatment.

Possible food and drug interactions when taking Aldactazide

If Aldactazide is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Aldactazide with the following:

ACE-inhibitor blood pressure drugs such as enalapril maleateAlcoholAntigout medications such as allopurinolBarbiturates such as phenobarbital and secobarbitalDigoxinDiuretics such as furosemideInsulin or oral antidiabetic drugs such as glyburideLithiumNarcotic drugs such as those containing codeineNonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen sodiumNorepinephrinePotassium supplements such as potassium chlorideSteroids such as prednisone

Special information if you are pregnant or breastfeeding

The effects of Aldactazide during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Aldactazide appears in breast milk and could affect a nursing infant. If Aldactazide is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.

Recommended dosage for Aldactazide


Congestive Heart Failure, Cirrhosis, Nephrotic Syndrome (kidney disorder)

The usual dosage is 100 milligrams each of spironolactone and hydrochlorothiazide daily, taken as a single dose or in divided doses. Dosage may range from 25 milligrams to 200 milligrams of each ingredient daily, depending on your individual needs.

High Blood Pressure

The usual dose is 50 milligrams to 100 milligrams each of spironolactone and hydrochlorothiazide daily, in a single dose or divided into smaller doses.


The usual dose of Aldactazide should provide 0.75 milligram to 1.5 milligrams of spironolactone per pound of body weight.


Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

  • Symptoms of Aldactazide overdose may include:Confusion, diarrhea, dizziness, drowsiness, nausea, patchy raised skin rash, vomiting
  • Aldactazide Prescribing Information (FDA)
  • Aldactazide Concise Consumer Information (Cerner Multum)
  • Aldactazide Advanced Consumer (Micromedex) - Includes Dosage Information
  • Aldactazide MedFacts Consumer Leaflet (Wolters Kluwer)

See Also...

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