Generic name: Erythromycin ethylsuccinate, Sulfisoxazole acetylBrand names: Eryzole, Pediazole
Pediazole is prescribed for the treatment of severe middle ear infections in children.
Sulfisoxazole is one of a group of drugs called sulfonamides, which prevent the growth of certain bacteria in the body. However, sulfonamides have been known to cause rare but sometimes fatal reactions such as Stevens-Johnson syndrome (a skin condition characterized by severe blisters and bleeding in the mucous membranes of the lips, mouth, nose, and eyes), sudden and severe liver damage, a severe blood disorder (agranulocytosis), and a lack of red and white blood cells because of a bone marrow disorder.
Notify your doctor at the first sign of a side effect such as skin rash, sore throat, fever, abnormal skin paleness, reddish or purplish skin spots, or yellowing of the skin or whites of the eyes.
Be sure to keep giving Pediazole for the full time prescribed, even if your child begins to feel better after the first few days. Keep to a regular schedule; the medication works best when there is a constant amount in the blood.
Pediazole can be given with or without food. However, you should not give Eryzole with or immediately after carbonated beverages, fruit juice, or tea. If the child develops an upset stomach, give the medicine with crackers or a light snack.
To prevent sediment in the urine and the formation of stones, make sure that the child drinks plenty of fluids during treatment with Pediazole.
This medication increases the skin's sensitivity to sunlight. Overexposure can cause a rash, itching, redness, or sunburn. Keep the child out of direct sunlight, or provide protective clothing.
Shake well before using.
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe to continue giving Pediazole.
If your child is sensitive to or has ever had an allergic reaction to erythromycin, sulfonamides, or other drugs of this type, do not use Eryzole. Make sure that your doctor is aware of any drug reactions that your child has experienced.
Pediazole should not be used if the child is taking astemizole or terfenadine.
This medication should not be prescribed for infants under 2 months of age.
Pediazole should not be taken by pregnant women at the end of their pregnancy or by mothers nursing infants under 2 months of age.
If your child has impaired kidney or liver function or a history of severe allergies or bronchial asthma, Pediazole may not be the best drug to use. Check with your doctor.
Prolonged or repeated use of Pediazole may cause new infections. If your child develops a new infection (called a superinfection), talk to your doctor. A different antibiotic may be needed.
If your child develops a cough or becomes short of breath, call your doctor. Also seek care immediately if the child develops diarrhea; it could signal a serious intestinal disorder.
If your child has the muscle-weakening disorder myasthenia gravis, Pediazole could make the condition worse.
Your doctor may recommend frequent urine tests while your child is taking Pediazole.
If Pediazole is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Pediazole with the following:Blood thinners such as warfarinBromocriptineCarbamazepineCyclosporineDigoxinDisopyramideErgotamineLovastatinMethotrexateOral antidiabetic drugs such as glyburidePhenytoinTheophyllineTriazolam
This drug is not prescribed for adults, and should never be taken at term of pregnancy or when breastfeeding.
The recommended dose for children 2 months of age or older is determined by weight. The total daily amount is divided into several smaller doses given 3 or 4 times a day for 10 days.
Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical treatment immediately.