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Drugs reference index «alefacept; water, sterile Intramuscular, Intravenous»

alefacept; water, sterile Intramuscular, Intravenous

alefacept; water, sterile (Intramuscular route, Intravenous route)

a-LEF-a-sept, WA-ter, STARE-il

Uses For alefacept; water, sterile

Alefacept is used in adult patients to treat moderate to severe psoriasis. alefacept; water, sterile is for patients who have used other medicines that have not worked for their psoriasis.

alefacept; water, sterile is available only with your doctor's prescription.

Before Using alefacept; water, sterile

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For alefacept; water, sterile, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to alefacept; water, sterile or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Studies on alefacept; water, sterile have been done only in adult patients, and there is no specific information comparing the use of alefacept in children with use in other age groups.


Many medicines have not been studied specifically in older people and it may not be known if they work the same way they do in younger adults. Elderly people may have more age related problems than younger people and may need less of alefacept; water, sterile.


Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of alefacept; water, sterile. Make sure you tell your doctor if you have any other medical problems, especially:

  • Human immunodeficiency virus (HIV) infection—alefacept; water, sterile should not be used in patients who have HIV infection.
  • Infection, moderate to severe—Alefacept could make your infections worse; your doctor may want to stop alefacept; water, sterile if you get an infection.
  • Lymphopenia (small amount of white blood cells)—alefacept; water, sterile could make this condition worse; your doctor may want to stop alefacept; water, sterile if your white blood cell counts are too low.
  • Cancer, history of—alefacept; water, sterile should not be used in patients with a history of cancer and it should be used with caution in patients at risk for cancer.

Proper Use of alefacept; water, sterile


The dose of alefacept; water, sterile will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of alefacept; water, sterile. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For parenteral dosage form
    • Psoriasis
      • Adults—15 milligrams (mg) injected into a muscle once a week for 12 weeks OR 7.5 milligrams (mg) injected into a vein once a week for 12 weeks
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of alefacept; water, sterile, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using alefacept; water, sterile

It is very important that your doctor check you at regular visits for any blood problems or any other side effects that may be caused by alefacept; water, sterile.

It is important to check with your doctor if you have any symptoms of an infection such as fever or chills, cough or hoarseness, lower back or side pain, painful or difficult urination. If your symptoms do not improve within a few days or if they become worse, check with your doctor.

You should contact your doctor right away if you develop persistent nausea, anorexia, fatigue, vomiting, abdominal pain, jaundice (yellow eyes and/or skin), easy bruising, dark urine, or pale stools.

It is important to tell your doctor if you become pregnant. Your doctor may want you join a pregnancy registry for patients taking alefacept; water, sterile.

alefacept; water, sterile Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Chills
  • cough
  • fever
  • hoarseness
  • lower back or side pain
  • painful or difficult urination
Less common
  • Body aches or pain
  • congestion
  • dryness or soreness of throat
  • infections, serious
  • runny nose
  • tender, swollen glands in neck
  • trouble in swallowing
  • voice changes
  • Arm, back or jaw pain
  • cardiovascular events
  • chest pain or discomfort
  • chest tightness or heaviness
  • fast or irregular heartbeat
  • nausea
  • pain or discomfort in arms, jaw, back or neck
  • shortness of breath
  • sweating
  • vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Injection site reactions, including pain, swelling, bleeding, skin rash or lumps
Less common
  • Difficulty in moving
  • dizziness
  • itching skin
  • joint pain
  • muscle aching or cramping
  • muscle pains or stiffness
  • swollen joints
  • Headache

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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