Generic Name: ethionamide (e thye on AM ide)Brand names: Trecator-SC, Trecator
Ethionamide is an antibiotic. It prevents the growth of bacteria in your body.
Ethionamide is used to treat tuberculosis (TB).
Ethionamide may also be used for purposes other than those listed in this medication guide.
Ethionamide may cause stomach upset, a loss of appetite, a metallic taste in your mouth, or excessive salivation (mouth watering). Notify your doctor if these side effects are persistent or severe.
Before taking this medication, tell your doctor if you
have ever had an allergic reaction to ethionamide;
have liver disease; or
have diabetes mellitus.
You may not be able to take ethionamide, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.It is not known whether ethionamide will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is also not known whether ethionamide will harm a nursing baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.
Take ethionamide exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.Take each dose with a full glass (8 ounces) of water.
Ethionamide can be taken with or without food. Taking ethionamide with food may decrease stomach upset.Take all of the ethionamide that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.
Ethionamide is usually combined with one or more other tuberculosis medicines.Store this medication at room temperature away from moisture and heat.
See also: Ethionamide dosage in more detail
Take the missed dose as soon as you remember. However, if it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.
Symptoms of an ethionamide overdose are unknown.
There are no restrictions on foods, beverages, or activities during treatment with ethionamide unless your doctor directs otherwise.
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
yellow skin or eyes;
numbness or tingling in your hands or feet;
blurred or double vision; or
confusion or abnormal behavior.
Other, less serious side effects may be more likely to occur. Continue to take ethionamide and talk to your doctor if you experience
nausea, vomiting, or loss of appetite;
a metallic taste in your mouth;
unusual fatigue or weakness;
tremors (shaking); or
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Tuberculosis -- Active:
500 mg to 1 g orally (15 to 20 mg/kg) in 1 or more divided doses per dayMaximum dose: 1 g orally per day Duration: Treatment should continue until permanent bacteriological conversion and maximal clinical improvement have occurred, generally, 18 to 24 months.
Usual Pediatric Dose for Tuberculosis -- Active:
10 to 20 mg/kg orally in 2 or 3 divided doses per day or 15 mg/kg orally once per day after meals.Maximum dose: 1 g orally per dayDuration: Treatment should continue until permanent bacteriological conversion and maximal clinical improvement have occurred, generally, 18 to 24 months.
The risk of seizures may be increased when ethionamide is used in combination with cycloserine (Seromycin) or isoniazid (Nydrazid). Special monitoring may be necessary if you are taking a combination of these medicines.
Drugs other than those listed here may also interact with ethionamide. Talk to your doctor and pharmacist before taking or using any other prescription or over-the-counter medicines.