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Drugs reference index «etidronate Oral, Intravenous»

etidronate Oral, Intravenous


etidronate (Oral route)

e-ti-DROE-nate

Commonly used brand name(s):

In the U.S.

  • Didronel

Available Dosage Forms:

  • Kit
  • Tablet

Therapeutic Class: Calcium Regulator

Chemical Class: Bisphosphonate

Uses For etidronate

Etidronate is used to treat Paget's disease of the bone. It may also be used to treat or prevent a certain type of bone problem (heterotopic ossification) after hip replacement surgery or spinal injury.

Etidronate is also used to treat hypercalcemia (too much calcium in the blood) that may occur with some types of cancer.

etidronate is available only with your doctor's prescription.

Before Using etidronate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For etidronate, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to etidronate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of etidronate in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of etidronate in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving etidronate.

Pregnancy

Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of etidronate. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Blood clotting problems or
  • Cancer or
  • Dental or tooth problems or
  • Dental procedures (e.g., tooth extraction) or
  • Infection or
  • Poor oral hygiene or
  • Surgery (e.g., dental surgery)—May increase risk for severe jaw problems.
  • Bone fracture, especially of arm or leg—Etidronate may increase the risk of bone fractures.
  • Enterocolitis (severe diarrhea) or
  • Hyperphosphatemia (high phosphate in the blood) or
  • Stomach or bowel problems (e.g., Barrett's esophagus, difficulty with swallowing, heartburn, inflammation of the esophagus, or ulcers)—Use with caution. May make these conditions worse.
  • Esophagus (the tube that runs from your throat to your stomach) problems or
  • Osteomalacia (soft bones) or
  • Trouble swallowing—Should not be used in patients with these conditions.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of etidronate

Take etidronate only as directed. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Make sure your doctor knows if your diet includes large amounts of calcium, such as milk or other dairy products, or if you are on any special diet, such as a low-sodium or low-sugar diet. Calcium in the diet may prevent the absorption of oral etidronate.

Take etidronate with a full glass (6 to 8 ounces) of water on an empty stomach at least 2 hours before or after food (mid-morning is best) or at bedtime. Food may decrease the amount of etidronate absorbed by your body.

Do not lie down for at least 30 minutes after taking etidronate, and do not lie down until after you have eaten some food.

In some patients, etidronate takes up to 3 months to work. If you feel that the medicine is not working, do not stop taking it on your own. Instead, check with your doctor.

It is important that you eat a well-balanced diet with an adequate amount of calcium and vitamin D (found in milk or other dairy products). Too much or too little of either may increase the chance of side effects while you are taking etidronate. Your doctor can help you choose the meal plan that is best for you. However, do not take any food, especially milk, milk formulas, or other dairy products, or antacids, mineral supplements, or other medicines that are high in calcium or iron (high amounts of these minerals may also be in some vitamin preparations), magnesium, or aluminum within 2 hours of taking etidronate. To do so may keep etidronate from working properly.

If etidronate upsets your stomach, ask your doctor if you can take two smaller doses instead of one larger dose. Do not change without talking to your doctor.

For treating Paget's disease, you may need to take etidronate for up to 6 months. Then after 90 days of not taking the medicine, your doctor may want you to start another course of treatment.

If you have Paget's disease, etidronate may work slowly, so you may not feel better until you have been using it for awhile. Do not stop taking it without talking to your doctor first. Your body may continue to respond to etidronate for several months after you stop using it.

Dosing

The dose of etidronate will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of etidronate. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For Paget's disease of bone:
      • Adults—Dose is based on body weight and must be determined by your doctor. At first, 5 milligrams (mg) per kilogram (kg) (2.3 mg per pound) of body weight a day, usually as a single dose, for not more than 6 months. Some people may need 6 to 10 mg per kg (2.7 to 4.6 mg per pound) of body weight a day for not more than 6 months. Others may need 11 to 20 mg per kg (5 to 9.1 mg per pound) of body weight a day for not more than 3 months. Your doctor may change your dose depending on your response to treatment.
      • Children—Use and dose must be determined by your doctor.
    • For treating or preventing a certain type of bone problem that may occur after hip replacement:
      • Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually 20 milligrams (mg) per kilogram (kg) (9.1 mg per pound) of body weight a day for 1 month before surgery, and for 3 months after surgery.
      • Children—Use and dose must be determined by your doctor.
    • For treating or preventing a certain type of bone problem that may occur after spinal injury:
      • Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually 20 milligrams (mg) per kilogram (kg) (9.1 mg per pound) of body weight a day for 2 weeks, beginning as soon as possible after your injury. Your doctor may then decrease your dose to 10 mg per kg (4.5 mg per pound) of body weight for an additional 10 weeks.
      • Children—Use and dose must be determined by your doctor.
    • For treating hypercalcemia (too much calcium in the blood):
      • Adults—Dose is based on body weight and must be determined by your doctor. The dose is usually 20 milligrams (mg) per kilogram (kg) (9.1 mg per pound) of body weight a day for 30 days. Treatment usually does not continue beyond 90 days.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of etidronate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using etidronate

It is important that your doctor check your progress at regular visits even if you are between treatments and are not taking etidronate. If your condition has improved and your doctor has told you to stop taking etidronate, your progress must still be checked. The results of laboratory tests or the occurrence of certain symptoms will tell your doctor if more medicine must be taken. Your doctor may want you to begin another course of treatment after you have been off the medicine for at least 3 months.

etidronate can irritate your esophagus. If you think etidronate has started to damage your esophagus, stop taking etidronate and call your doctor. Some symptoms of damage to the esophagus are heartburn (either new or worse than usual), pain when swallowing, pain in the center of your chest, trouble swallowing, or feeling that food gets stuck on the way to your stomach.

It is important that you tell all of your health care providers that you are taking etidronate. If you are having dental procedures done while taking etidronate you may have an increased chance of getting a severe problem of your jaw. Tell your doctor right away if you have jaw tightness; swelling, numbing, or pain; or a loose tooth.

If etidronate causes you to have nausea or diarrhea and it continues, check with your doctor. The dose may need to be changed.

Make sure you tell your doctor about any new medical problems, especially with your teeth or jaws. Tell your doctor if you have severe bone, joint, or muscle pain while using etidronate.

etidronate Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Bone pain or tenderness (increased, continuing, or returning—in patients with Paget's disease)
Less common
  • Bone fractures, especially of the thigh bone
Rare
  • Hives
  • skin rash or itching
  • swelling of the arms, legs, face, lips, tongue, or throat
Incidence not known
  • Bone, joint, or muscle pain that is severe and occasionally disabling
  • heavy jaw feeling
  • loosening of a tooth
  • pain, swelling, or numbness in the mouth or jaw

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common - at higher doses
  • Diarrhea
  • nausea

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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