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Drugs reference index «etoposide»

etoposide


etoposide

Generic Name: etoposide (oral) (ee TOW poh side)Brand names: VePesid, Etopophos (obsolete), Toposar

What is etoposide?

Etoposide is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body.

Etoposide is used to treat cancer of the lung or testicles.

Etoposide may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about etoposide?

Do not use this medication without your doctor's consent if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. Do not break or open an etoposide capsule. The medicine from a broken capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If skin contact occurs, wash the area with soap and water or rinse the eyes thoroughly with plain water. If you must handle a broken capsule, ask your doctor or pharmacist how to safely dispose of the capsule.

Etoposide can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Using etoposide may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

What should I discuss with my healthcare provider before taking etoposide?

Before using etoposide, tell your doctor if you have:

  • kidney disease; or
  • a weak immune system (from disease or from taking certain medicines).

If you have any of these conditions, you may not be able to use etoposide, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use etoposide without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. It is not known whether etoposide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Using etoposide may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

How should I use etoposide?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Take each dose with a full glass of water. Do not break or open an etoposide capsule. The medicine from a broken capsule can be dangerous if it gets in your eyes, mouth, or nose, or on your skin. If skin contact occurs, wash the area with soap and water or rinse the eyes thoroughly with plain water. If you must handle a broken capsule, ask your doctor or pharmacist how to safely dispose of the capsule.

Etoposide can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Store etoposide capsules in the refrigerator. Do not allow them to freeze.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an etoposide overdose may include severe nausea and vomiting, fever, chills, sore throat, flu symptoms, easy bruising, or extreme weakness.

What should I avoid while using etoposide?

Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection.

Do not receive a "live" vaccine while you are being treated with etoposide.

Etoposide side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • fever, chills, body aches, flu symptoms;

  • white patches or sores inside your mouth or on your lips;

  • easy bruising or bleeding, unusual weakness;

  • fast heart rate;

  • severe nausea and vomiting;

  • feeling light-headed, fainting; or

  • low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Other, less serious side effects may be more likely to occur, such as:

  • mild nausea, vomiting, stomach pain;

  • mild itching or skin rash; or

  • temporary hair loss.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Etoposide Dosing Information

Usual Adult Dose for Testicular Cancer:

(In combination with other approved chemotherapeutic agents) Initial dose: 50 to 100 mg/m?? IV once a day on days 1 through 5 or 100 mg/m2 IV once a day on days 1,3 and 5.

Usual Adult Dose for Small Cell Lung Cancer:

(In combination with other approved chemotherapeutic agents) Initial dose: 35 to 50 mg/m2 IV once a day for 4 to 5 days or70 to 100 mg/m2 orally once a day for 4 to 5 days.

Usual Adult Dose for Hodgkin's Disease:

(In combination with other chemotherapeutic agents as a part of the BEACOPP and EVA regimens) 100 mg/m2/day on days 1, 2, and 3Total Dose/Cycle = 300 mg/m2(In combination with other chemotherapeutic agents as a part of the mini-BEAM regimen)75 mg/m2/day on days 2 through 5Total Dose/Cycle = 300 mg/m2(In combination with other chemotherapeutic agents as a part of the Stanford V regimen)60 mg/m2/day on days 15 and 16Total Dose/Cycle = 120 mg/m2

Usual Adult Dose for Ovarian Cancer:

For use in the treatment of epithelial ovarian cancer:50 mg/m2 daily on days 1 through 21For use in the treatment of germ cell ovarian cancer:(In combination with other approved chemotherapeutic agents as a part of the BEP regimen)100 mg/m2 IV on days 1 through 5

Usual Geriatric Dose for Testicular Cancer:

The manufacturer has stated that clinical studies of etoposide for the treatment of refractory testicular tumors did not include sufficient numbers of patients aged 65 years or over to determine if they respond differently from younger patients.

Usual Pediatric Dose for Malignant Disease:

Note: Oral doses are twice the IV doses listed below. Oral doses are to be administered once a day if <=400 mg. Divided doses are recommended if the dose exceeds 400 mg/day.60 to 150 mg/m2/day IV for 2 to 5 days every 3 to 6 weeks.Remission induction for AML: 150 mg/m2/day IV for 2 to 3 days for 2 to 3 cycles.Intensification/Consolidation for AML: 250 mg/m2/day IV for 3 days, courses 2 to 5.Brain Tumor: 150 mg/m2/day IV on days 2 and 3.Neuroblastoma: 100 mg/m2/day IV over 1 hour on days 1through 5 of the cycle, repeated every 4 weeks.High-dose conditioning regimen for allogenic BMT: 60 mg/kg/dose IV as a single dose.BMT conditioning regimen used in patients with rhabdomyosarcoma or neuroblastoma: IV continuous infusion: 160 mg/m2/day for 4 days.

What other drugs will affect etoposide?

Before using etoposide, tell your doctor if you are using cyclosporine (Neoral, Sandimmune, Gengraf).

There may be other drugs that can affect etoposide. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist has more information about etoposide written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.07. Revision Date: 4/12/2009 4:36:33 PM.
  • etoposide Oral, Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
  • Etoposide Prescribing Information (FDA)
  • Etoposide MedFacts Consumer Leaflet (Wolters Kluwer)
  • Etoposide Professional Patient Advice (Wolters Kluwer)
  • Toposar Prescribing Information (FDA)
  • VePesid Prescribing Information (FDA)
  • VePesid MedFacts Consumer Leaflet (Wolters Kluwer)

See Also...

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