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Drugs reference index «etoposide phosphate»

etoposide phosphate

Generic Name: etoposide phosphate (e TOE poe side FOS fate)Brand Names: Etopophos

What is etoposide phosphate?

Etoposide phosphate is a cancer medicine that interferes with the growth of cancer cells and slows their growth and spread in the body.

Etoposide phosphate is used to treat cancer of the lung or testicles.

Etoposide phosphate may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about etoposide phosphate?

Do not receive etoposide phosphate without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Before receiving etoposide phosphate, tell your doctor if you have kidney disease or a weak immune system.

Etoposide phosphate can lower the blood cells that help your body fight infections. Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis.

Do not receive a "live" vaccine while you are being treated with etoposide phosphate. Live vaccines include measles, mumps, rubella (MMR), oral polio, chickenpox (varicella), BCG (Bacillus Calmette and Guérin), and nasal flu vaccine.

Using etoposide phosphate may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

What should I discuss with my health care provider before using etoposide phosphate?You should not use this medication if you are allergic to etoposide.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • kidney disease; or
  • a weak immune system (from disease or from taking certain medicines).

FDA pregnancy category D. Do not receive etoposide phosphate without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether etoposide phosphate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Using etoposide phosphate may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

How is etoposide phosphate given?

Etoposide phosphate is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine is sometimes given slowly through an IV infusion, and can take up to 3-1/2 hours to complete.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.

Etoposide phosphate is usually given for 4 or 5 days in a row every 3 to 4 weeks. Follow your doctor's instructions.

Etoposide phosphate can lower the blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor.

Etoposide phosphate is used together with other cancer medications. Be sure to read the medication guide or patient instructions provided with each of your medications.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your etoposide phosphate injection.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine. Overdose symptoms may include problems with speech, vision, thinking, or balance.

What should I avoid while receiving etoposide phosphate?

Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while you are being treated with etoposide phosphate. Live vaccines include measles, mumps, rubella (MMR), oral polio, chickenpox (varicella), BCG (Bacillus Calmette and Guérin), and nasal flu vaccine.

Etoposide phosphate side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • fever, chills, body aches, flu symptoms;

  • white patches or sores inside your mouth or on your lips;

  • pale skin, easy bruising or bleeding, unusual weakness;

  • feeling like you might pass out;

  • severe nausea and vomiting;

  • black, bloody, or tarry stools; or

  • coughing up blood or vomit that looks like coffee grounds.

Less serious side effects may include:

  • mild nausea, vomiting, stomach pain, loss of appetite;

  • constipation, diarrhea;

  • dizziness, tired feeling;

  • change in your sense of taste;

  • temporary hair loss; or

  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Etoposide phosphate Dosing Information

Usual Adult Dose for Testicular Cancer:

(In combination with other approved chemotherapeutic agents) Initial dose: 50 to 100 mg/m2 IV once a day on days 1 through 5 or 100 mg/m2 IV once a day on days 1,3 and 5.

Usual Adult Dose for Small Cell Lung Cancer:

(In combination with other approved chemotherapeutic agents) Initial dose: 35 to 50 mg/m2 IV once a day for 4 to 5 days.

Usual Geriatric Dose for Testicular Cancer:

The manufacturer has stated that clinical studies of etoposide for the treatment of refractory testicular tumors did not include sufficient numbers of patients aged 65 years or over to determine if they respond differently from younger patients.

What other drugs will affect etoposide phosphate?

Before you receive etoposide phosphate, tell your doctor if you are using cyclosporine (Neoral, Sandimmune, Gengraf).

This list is not complete and there may be other drugs that can interact with etoposide phosphate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about etoposide phosphate.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.02. Revision Date: 07/31/2009 8:30:19 AM.
  • Etopophos Prescribing Information (FDA)
  • Etopophos Advanced Consumer (Micromedex) - Includes Dosage Information
  • Etopophos MedFacts Consumer Leaflet (Wolters Kluwer)

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