Generic Name: everolimus (E ver OH li mus)Brand Names: Afinitor
Everolimus is used to treat advanced kidney cancer.
Everolimus is usually given after sorafenib (Nexavar) or sunitinib (Sutent) have been tried without successful treatment of symptoms.
Everolimus may also be used for other purposes not listed in this medication guide.
Before taking everolimus, tell your doctor if you have a breathing disorder, such as asthma or COPD, liver disease, diabetes, or high cholesterol.Do not receive a "live" vaccine while you are being treated with everolimus, and avoid coming into contact with anyone who has recently received a live vaccine (including measles, mumps, rubella, oral polio, chickenpox, BCG, and nasal flu vaccine). There are many other medicines that can interact with everolimus. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.
To be sure this medication is not causing harmful effects, your blood may need to be tested on a regular basis. Your kidney function may also need to be tested. Do not miss any follow-up visits to your doctor.
Call your doctor at once if you have a serious side effect such as stabbing chest pain, feeling short of breath, fever, chills, cough, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, or unusual weakness.
If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:
a breathing disorder, such as asthma or COPD (chronic obstructive pulmonary disease);
high cholesterol or triglycerides.
Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.
Everolimus should be taken at the same time each day.Take this medication with a full glass (8 ounces) of water. Swallow the tablet whole. Do not crush or chew.
You may take everolimus with or without food.
Your doctor may occasionally change your dose to make sure you get the best results from this medication.
To be sure this medication is not causing harmful effects, your blood may need to be tested on a regular basis. Your kidney function may also need to be tested. Do not miss any follow-up visits to your doctor.Store everolimus at room temperature away from moisture, heat, and light.
See also: Everolimus dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.
Symptoms of an everolimus overdose symptoms are not known.
fever, chills, cough with yellow or green mucus;
stabbing chest pain, feeling short of breath;
white patches or sores inside your mouth or on your lips; or
other signs of infection such as sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, or unusual weakness.
Less serious side effects may include:
stomach pain, diarrhea;
swelling, weight gain;
dry skin; or
sleep problems (insomnia);
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Renal Cell Carcinoma:
Recommended dose: 10 mg orally once daily to be taken at the same time every day, either with or without food. Everolimus tablets should be swallowed whole with a glass of water. The tablets should not be chewed or crushed.Treatment should be continued as long as clinical benefit is observed or until unacceptable toxicity occurs.
Many drugs can interact with everolimus. Below is just a partial list. Tell your doctor if you are using:
dexamethasone (Decadron, Hexadrol);
diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);
isoniazid (for treating tuberculosis);
phenylbutazone (Azolid, Butazolidin);
St. John's wort;
an antidepressant such as nefazodone;
an antibiotic such as clarithromycin (Biaxin), clotrimazole (Mycelex Troche), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), rifabutin (Mycobutin), rifampin (Rifadin, Rifater, Rifamate), rifapentine (Priftin), telithromycin (Ketek), or voriconazole (Vfend);
a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton);
heart or blood pressure medication such as diltiazem (Cardizem, Dilacor, Tiazac), nicardipine (Cardene), quinidine (Quinaglute, Quinidex, Quin-Release), or verapamil (Calan, Covera, Isoptin, Verelan);
HIV or AIDS medication such as amprenavir (Agenerase), atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), etravirine (Intelence), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), or saquinavir (Invirase);
medicines to treat narcolepsy, such as armodafanil (Nuvigil) or modafanil (Progivil); or
seizure medication such as carbamazepine (Carbatrol, Tegretol), felbamate (Felbatol), oxcarbazepine (Trileptal), or phenytoin (Dilantin), or primidone (Mysoline).