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Drugs reference index «exemestane»

exemestane
exemestane
exemestane


exemestane

Generic Name: exemestane (ex e MES tane)Brand Names: Aromasin

What is exemestane?

Exemestane lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Exemestane is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen (Nolvadex, Soltamox) for 2 to 3 years.

Exemestane may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about exemestane?

This medication can cause harm to an unborn baby. Do not use exemestane without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

You may need to take a pregnancy test before using exemestane, to make sure you are not pregnant.

You also should not use this medication if you are breast-feeding a baby, or if you are allergic to exemestane.

Before using exemestane, tell your doctor if you have severe liver or kidney disease, or if you have not yet completed menopause. If you have any of these conditions, you may need a dose adjustment or special tests to safely take exemestane.

You may need to keep taking exemestane for up to 5 years. Follow your doctor's instructions.

Exemestane may not work as well if you take it together with hormone replacement medication, or while using birth control pills or patches.

What should I discuss with my healthcare provider before taking exemestane?

You should not use this medication if you are allergic to exemestane, or if you are pregnant or breast-feeding.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

  • liver disease;

  • kidney disease; or

  • not yet completed menopause.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use exemestane without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

You may need to take a pregnancy test before using exemestane, to make sure you are not pregnant.

It is not known whether exemestane passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take exemestane?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Exemestane is usually taken once per day. You may need to keep taking take this medication for up to 5 years. Follow your doctor's instructions.

To be sure this medication is not causing harmful effects, your blood may need to be tested on a regular basis. Do not miss any follow-up visits to your doctor.

Store exemestane at room temperature away from moisture and heat.

See also: Exemestane dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include stomach pain, nausea, vomiting, or blood in your stools.

What should I avoid while taking exemestane?

Exemestane can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Exemestane side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • swollen glands;

  • a bone fracture;

  • swelling in your hands or feet;

  • feeling short of breath, even with mild exertion; or

  • chest pain, sudden numbness or weakness, sudden headache, confusion, problems with vision, speech, or balance.

Less serious side effects may include:

  • hot flashes;

  • anxiety;

  • upset stomach;

  • joint pain or stiffness;

  • weakness, headache, tired feeling;

  • depressed mood;

  • sleep problems (insomnia); or

  • increased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Exemestane Dosing Information

Usual Adult Dose for Breast Cancer:

For early and advanced breast cancer:Recommended dose: 25 mg orally once daily after a meal.In postmenopausal women with early breast cancer who have been treated with two to three years of tamoxifen, treatment with exemestane should continue in the absence of recurrence or contralateral breast cancer until completion of five years of adjuvant endocrine therapy.For patients with advanced breast cancer, treatment with exemestane should continue until tumor progression is evident.

What other drugs will affect exemestane?

Exemestane may not work as well if you take it together with hormone replacement medication, or while using birth control pills or patches.

Before you start taking exemestane, tell your doctor if you use any of the following drugs:

  • rifampin (Rifadin, Rimactane, Rifater);

  • St. John's wort; or

  • seizure medication such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin).

This list is not complete and there may be other drugs that can interact with exemestane. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about exemestane.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 2.02. Revision Date: 07/20/2009 9:12:13 AM.
  • exemestane Advanced Consumer (Micromedex) - Includes Dosage Information
  • Exemestane Professional Patient Advice (Wolters Kluwer)
  • Exemestane MedFacts Consumer Leaflet (Wolters Kluwer)
  • Aromasin Prescribing Information (FDA)
  • Aromasin Consumer Overview

See Also...

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