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Drugs reference index «Exenatide»


Generic Name: Exenatide (ex-EN-a-tide)Brand Name: Byetta

Exenatide is used for:

Treating type 2 diabetes.

Exenatide is an incretin mimetic. It lowers blood sugar by increasing the release of insulin from the pancreas. It also mimics the actions of certain hormones that lower blood sugar levels.

Do NOT use Exenatide if:

  • you are allergic to any ingredient in Exenatide
  • you have type 1 diabetes
  • you have severe kidney problems or severe stomach or bowel problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Exenatide :

Some medical conditions may interact with Exenatide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a buildup of ketones in the blood (diabetic ketoacidosis)
  • if you have a history of stomach or bowel problems, gallbladder problems (eg, gallstones), pancreas problems, high blood triglyceride levels, alcohol abuse, kidney problems or kidney transplant, or if you receive dialysis
  • if you are also using insulin

Some MEDICINES MAY INTERACT with Exenatide . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Sulfonylureas (eg, glipizide) or thiazolidinediones (eg, pioglitazone) because the risk of low blood sugar may be increased
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, lisinopril), diuretics (eg, furosemide, hydrochlorothiazide), or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of kidney problems may be increased
  • Anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Exenatide

Ask your health care provider if Exenatide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Exenatide :

Use Exenatide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet and a pen user manual are available with Exenatide . Talk to your pharmacist if you have questions about this information.
  • Use Exenatide within 60 minutes before your morning and evening meals (or before the 2 main meals of the day), unless your doctor tells you otherwise. Do NOT use it after a meal. Your doses of Exenatide should be about 6 hours or more apart.
  • If you will be using Exenatide at home, a health care provider will teach you how to use it. Be sure you understand how to use Exenatide . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Inject Exenatide into your upper leg (thigh), stomach area (abdomen), or upper arm as directed by your doctor or other health care provider.
  • Do not use Exenatide if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • If you are taking certain medicines by mouth (eg, antibiotics, birth control pills), you may need to take them at least 1 hour before you use Exenatide . Ask your doctor, pharmacist, or other health care provider if you need to take any of your medicines at a different time than Exenatide .
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Exenatide , skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Exenatide .

Important safety information:

  • Exenatide may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Exenatide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not use more than the recommended dose without checking with your doctor.
  • Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take Exenatide exactly as prescribed, tell your doctor.
  • Follow the diet and exercise program given to you by your health care provider. Proper diet, regular exercise, and regular testing of blood sugar are important for best results when using Exenatide .
  • The risk of low blood sugar may be increased when Exenatide is used with certain other diabetes medicines (eg, sulfonylureas, thiazolidinediones). Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
  • Exenatide may decrease your appetite, the amount of food you eat, and your weight. This is normal. Do not change your dose of Exenatide without checking with your doctor.
  • Patients taking Exenatide have developed severe and sometimes fatal pancreas problems. Contact your doctor right away if you develop severe or persistent stomach pain that may radiate to the back; severe or persistent nausea or vomiting; fever; swollen or tender abdomen; or fast heartbeat.
  • If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
  • Do not store the pen with the needle attached. If the needle is left on, the medicine may leak from the pen or air bubbles may form in the cartridge.
  • Lab tests, including hemoglobin A1c levels and blood sugar levels, may be performed while you use Exenatide . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Exenatide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Exenatide while you are pregnant. It is not known if Exenatide is found in breast milk. If you are or will be breast-feeding while you use Exenatide , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Exenatide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Decreased appetite; diarrhea; dizziness; feeling jittery; headache; indigestion; nausea; vomiting; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine produced; chest pain; symptoms of low blood sugar (eg, chills, confusion, drowsiness, fainting, fast heartbeat, increased hunger, increased sweating, irritability, nervousness, severe dizziness, tremor, vision problems, weakness); unusual, severe, or persistent stomach pain or vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org), or emergency room immediately. Symptoms may include dizziness; severe low blood sugar, nausea, and vomiting.

Proper storage of Exenatide :

Store unused (unopened) pens in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Do not use Exenatide if it has been frozen. Store used (open) pens below 77 degrees F (25 degrees C). Protect from light. Do not store with the needle attached to the pen. Throw away a used pen after 30 days, even if some medicine remains in the pen. Do not use past the expiration date. Keep Exenatide out of the reach of children and away from pets.

General information:

  • If you have any questions about Exenatide , please talk with your doctor, pharmacist, or other health care provider.
  • Exenatide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Exenatide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Exenatide Professional Patient Advice (Wolters Kluwer)
  • Exenatide Detailed Consumer Information (PDR)
  • exenatide Concise Consumer Information (Cerner Multum)
  • exenatide Subcutaneous Advanced Consumer (Micromedex) - Includes Dosage Information

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