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Drugs reference index «fluconazole»

fluconazole


fluconazole

Generic Name: fluconazole (floo KOE na zole)Brand Names: Diflucan

What is fluconazole?

Fluconazole is an antifungal antibiotic.

Fluconazole is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, genital area, and the blood.

Fluconazole is also used to prevent fungal infection in people with weak immune systems caused by cancer treatment, bone marrow transplant, or diseases such as AIDS.

Fluconazole may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about fluconazole?

Do not use this medication if you are allergic to fluconazole, or similar drugs such as clotrimazole (Lotrimin), econazole (Spectazole), ketoconazole (Nizoral), miconazole (Monistat), sertaconazole (Ertaczo), sulconazole (Exelderm), terconazole (Terazol), tioconazole (Vagistat-1), or voriconazole (Vfend). Do not use fluconazole if you are also taking cisapride (Propulsid) or terfenadine (Seldane).

Before taking fluconazole, tell your doctor if you have liver disease, kidney disease, a heart rhythm disorder, or a history of "Long QT syndrome."

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Fluconazole will not treat a viral infection such as the common cold or flu.

What should I discuss with my healthcare provider before taking fluconazole?

Do not use this medication if you are allergic to fluconazole, or similar drugs such as clotrimazole (Lotrimin), econazole (Spectazole), ketoconazole (Nizoral), miconazole (Monistat), sertaconazole (Ertaczo), sulconazole (Exelderm), terconazole (Terazol), tioconazole (Vagistat-1), or voriconazole (Vfend). Do not use fluconazole if you are also taking cisapride (Propulsid).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take fluconazole:

  • liver disease;

  • kidney disease;

  • a heart rhythm disorder; or

  • a personal or family history of "Long QT syndrome."

FDA pregnancy category C. It is not known whether fluconazole is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Fluconazole can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take fluconazole?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your dose will depend on the infection you are treating. Vaginal infections are often treated with only one pill. For other infections, your first dose may be a double dose. Carefully follow your doctor's instructions. Tell your doctor if your symptoms do not improve.

Take this medicine with a full glass of water. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Fluconazole will not treat a viral infection such as the common cold or flu. Store the tablets at room temperature away from moisture and heat. You may store liquid fluconazole in a refrigerator, but do not allow it to freeze. Throw away any leftover liquid medicine that is more than 2 weeks old.

See also: Fluconazole dosage in more detail

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a fluconazole overdose may include confusion or unusual thoughts or behavior.

What should I avoid while taking fluconazole?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using fluconazole.

Fluconazole side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • fever, chills, body aches, flu symptoms;

  • severe blistering, peeling, and red skin rash;

  • easy bruising or bleeding, unusual weakness; or

  • seizure (convulsions).

Less serious side effects may include:

  • mild nausea, vomiting, diarrhea, or upset stomach;

  • headache;

  • dizziness;

  • unusual or unpleasant taste in your mouth; or

  • skin rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Fluconazole Dosing Information

Usual Adult Dose for Vaginal Candidiasis:

150 mg orally as a single dose.

Usual Adult Dose for Oral Thrush:

200 mg followed by 100 mg orally or IV once a day. Doses of 50 to 100 mg orally once a day may be used for prophylaxis of HIV-related thrush. Doses of 200 mg orally once a day or 400 mg orally once a week have also been used. Therapy should be continued for at least 2 weeks to decrease the likelihood of relapse.

Usual Adult Dose for Candidemia:

200 mg IV or orally once a day. Doses up to 400 mg/day have been used. Therapy should be continued for at least 4 weeks and at least 2 weeks following resolution of symptoms.Prophylaxis in Febrile Neutropenia:400 mg/day starting the day of hematopoietic stem cell transplantation (HSCT) to at least day 75.

Usual Adult Dose for Esophageal Candidiasis:

200 mg on the first day followed by 100 mg orally or IV once a day. Doses up to 400 mg/day may be used. Therapy should be continued for at least 3 weeks and for at least 2 weeks following resolution of symptoms. Doses of 50 to 100 mg orally once a day may be used for prophylaxis of HIV-related esophageal candidiasis. Doses of 200 mg orally once a day, or 400 mg orally once a week have also been used.

Usual Adult Dose for Candida Urinary Tract Infection:

100 mg orally or IV once a day. Doses may range from 50 to 200 mg/day.

Usual Adult Dose for Coccidioidomycosis -- Meningitis:

400 mg IV or orally once a day. Therapy should be continued for 1 year after normalization of the CSF to prevent relapse. Many experts recommend that fluconazole therapy be continued for the lifetime of the patient.

Usual Adult Dose for Coccidioidomycosis:

100 to 400 mg orally or IV once a day. Therapy should be continued for 1 to 3 months. Relapse is common. Lifetime therapy is required for HIV positive or AIDS patients.

Usual Adult Dose for Cryptococcal Meningitis -- Immunocompetent Host:

400 mg on the first day, followed by 200 to 400 mg IV or orally once a day. Therapy should be continued for 10 to 12 weeks after CSF culture is negative. Patients should be monitored for at least 1 year for relapse. Fluconazole 200 mg orally once a day may be used to prevent relapse.

Usual Adult Dose for Cryptococcosis:

100 to 400 mg orally or IV once a day. The duration of therapy should be 4 to 8 weeks. Patients should be monitored for at least 1 year for relapse. Fluconazole 200 mg orally once a day may be used for suppression of relapse. Lifelong therapy is required for HIV positive or AIDS patients.

Usual Adult Dose for Histoplasmosis:

200 mg IV or orally once a day. The duration of therapy should be 6 to 12 months in patients without meningitis or endocarditis, which require more prolonged therapy.

Usual Adult Dose for Fungal Peritonitis:

100 to 200 mg orally or IV once a day. The duration of therapy should be at least 4 weeks and at least 2 weeks following resolution of symptoms.

Usual Adult Dose for Chronic Mucocutaneous Candidiasis:

100 to 200 mg orally or IV once a day. Generally requires long term maintenance therapy.

Usual Adult Dose for Bone Marrow Transplantation:

400 mg orally or IV once a day. May start several days before the anticipated onset of neutropenia (less than 500 neutrophils per cu mm), and continued for 7 days after the neutrophil count rises above 1000 cells per cu mm.

Usual Adult Dose for Blastomycosis:

400 to 800 mg orally once a day. Therapy should be continued for at least 6 months.

Usual Adult Dose for Onychomycosis -- Fingernail:

150 to 300 mg orally once a week. Therapy should be continued for 3 to 6 months.

Usual Adult Dose for Onychomycosis -- Toenail:

150 to 300 mg orally once a week. Therapy should be continued for 6 to 12 months.

Usual Pediatric Dose for Esophageal Candidiasis:

Greater than 2 weeks: 6 mg/kg on the first day, followed by 3 mg/kg once a day, orally or IV. Doses up to 12 mg/kg/day have been used. Treatment should continue for at least 3 weeks and for at least 2 weeks following the resolution of symptoms.

Usual Pediatric Dose for Oral Thrush:

Greater than 2 weeks: 6 mg/kg on the first day, followed by 3 mg/kg once a day, orally or IV. Treatment should continue for at least 2 weeks.

Usual Pediatric Dose for Candidemia:

Greater than 2 weeks: 6 to 12 mg/kg/day, IV or orally

Usual Pediatric Dose for Cryptococcal Meningitis -- Immunocompetent Host:

Greater than 2 weeks:12 mg/kg on the first day, followed by 6 to 12 mg/kg once a day, IV or orally. For suppression of relapse in children with AIDS: 6 mg/kg once a day.

What other drugs will affect fluconazole?

Before taking fluconazole, tell your doctor if you are using any of the following drugs:

  • a blood thinner such as warfarin (Coumadin);

  • clopidogrel (Plavix);

  • cyclosporine (Gengraf, Sandimmune, Neoral);

  • an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), tolbutamide (Orinase), tolazamide (Tolinase), chlorpropamide (Diabinese), and others;

  • rifabutin (Mycobutin) or rifampin (Rifadin, Rifater, Rifamate, Rimactane);

  • a sedative such as diazepam (Valium), lorazepam (Ativan), alprazolam (Xanax), or midazolam (Versed);

  • seizure medication such as phenytoin (Dilantin) or valproic acid (Depakene);

  • tacrolimus ((Prograf); or

  • theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin, others).

This list is not complete and there may be other drugs that can interact with fluconazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about fluconazole.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 6.01. Revision Date: 11/18/2009 10:04:18 AM.
  • fluconazole Advanced Consumer (Micromedex) - Includes Dosage Information
  • Fluconazole Prescribing Information (FDA)
  • Fluconazole Professional Patient Advice (Wolters Kluwer)
  • Fluconazole Detailed Consumer Information (PDR)
  • Fluconazole MedFacts Consumer Leaflet (Wolters Kluwer)
  • Diflucan Prescribing Information (FDA)
  • Diflucan Consumer Overview

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