Analysis, linkage: Study aimed at establishing linkage between genes. Today linkage analysis serves as a way of gene-hunting and genetic testing.
Linkage is the tendency for genes and other genetic markers to be inherited together because of their location near one another on the same chromosome.
A gene is a functional physical unit of heredity that can be passed from parent to child. All genes in humans are pieces of DNA. Most genes contain information for making a specific protein.
The term "genetic marker" is broader than a gene. A genetic marker is simply a segment of DNA with an identifiable physical location on a chromosome whose inheritance can be followed. A genetic marker can have a function and thus be a gene. Or a marker can be a section of DNA with no known function.
Because DNA segments that lie near each other on a chromosome tend to be inherited together, markers are often used as tools for tracking the inheritance pattern of a gene that has not yet been identified but whose approximate location is known.
The statistical estimate of whether two loci are likely to lie near each other on a chromosome and are therefore likely to be inherited together is called a LOD score. A LOD score of 3 or more is generally taken to indicate that the two loci are linked and are close to one another.
name what it does ; LINKAGE: pedigree linkage analysis: user's guide, help file for PC version: EH : estimate LD (linkage disequilibrium): user's guide,
MERLIN Tutorial -- Linkage Analysis. Linkage analysis tests for co-segregation of a chromosomal region and a trait of interest. In this section, we will walk through a ...
Linkage analysis: Study aimed at establishing linkage between genes. Today linkage analysis serves as a way of gene-hunting and genetic testing.
Linkage analysis 20/3/03. By Richard Twyman Finding the rough position of human disease genes relative to known genetic ...
This is a list of genetic linkage analysis software provided to NIH by CIT/DCB/ BIMAS. This software is made available through ALW workstations running AFS, on CIT's ...