Annexin V: Annexin V is the cause of a syndrome called the antiphospholipid antibody syndrome with abnormal blood clotting.
The annexins are a family of proteins first described in 1990. All of the annexin proteins share the property of binding calcium and phospholipids.
Annexin V normally forms a shield around certain phospholipid molecules that blocks their entry into coagulation (clotting) reactions. In the antiphospholipid antibody syndrome, the formation of this shield is disrupted by the abnormal antibodies. Without the shield, there is an increased quantity of phospholipid molecules on cell membranes, speeding up coagulation reactions and causing the abnormal blood clotting characteristic of the antiphospholipid antibody syndrome.
First printed in R&D Systems' 1996 Catalog. Overview. Annexin V is a member of a calcium and phospholipid binding family of proteins with vascular anticoagulant activity.
Adherent RAW cells treated with actinomycin-D, detached with Accutase, our cell detachment solution and stained with the PFS V-Annexin-V Kit . Apoptosis is the term that ...
Detect one of the earliest events in apoptosisâ€”the externalization of phosphatidylserineâ€”in living cells
Annexin V Staining Protocol General Annexin V Staining Procedure Solutions. 10X Binding Buffer (cat. no. 556454): 0.1 M HEPES, pH 7.4; 1.4 M NaCl; 25 mM CaCl 2.
Annexin V-FITC Kit ( #130-092-052 ) - staining apoptosis apoptotic MACS AnxV dead cells propidium iodide Annexin V-FITC Kit